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- BookArthur V. Everitt, Suresh I.S. Rattan, David G. Le Couteur, Rafael de Cabo, editors.Contents:
Part 1. CALORIE RESTRICTION IN DIFFERENT SPECIES
History of Caloric Restriction, Aging and Longevity / Edward J. Masoro
Food Intake, Life Style, Aging and Human Longevity / Arthur V. Everitt, Leonie K. Heilbronn and David G. Le Couteur
Okinawa: A Naturally Calorie Restricted Population / Matthew W. Rosenbaum, Bradley J. Willcox, D. Craig Willcox and Makoto Suzuki
Aging and the Effect of Calorie Restriction in Rhesus Monkeys / Ilhem Messaoudi, Jennifer E. Young, Ricki J. Colman, April M. Handy and George S. Roth, et al.
Dietary Restriction and Aging in Drosophila Melanogaster / Luc Poirier, Rafael de Cabo and Sige Zou
Aging and Dietary Restriction: The Yeast Paradigm / Min Wei, Federica Madia, Rafael de Cabo and Valter D. Longo
The Nutritional Geometry of Aging / Stephen J. Simpson and David Raubenheimer
Part 2. BIOCHEMICAL AND METABOLIC MECHANISMS OF CALORIE RESTRICTION
Oxidative Stress, Dietary Restriction and Aging / Brian J. Merry and Catherine E. Ash
Calorie Restriction Mimetics and Aging / Brian J. Morris
Will Calorie Restriction Stave Off Age-Related Brain Dysfunction, Specifically to Learning and Memory? A Review and Critique of the Rodent Literature / Edward L. Spangler, Jeffrey Long, Bennett Kelley-Bell, Marshall Miller and Robin K. Minor, et al.
The Aging Liver and the Effects of Long Term Caloric Restriction / David G. Le Couteur, David A. Sinclair, Victoria C. Cogger, Aisling C. McMahon and Alessandra Warren, et al.
Food Restriction, Hormones, Genes and Aging / Arthur V. Everitt, Holly M. Brown-Borg, David G. Le Couteur and Andrzej Bartke
Hormesis as a Mechanism for the Anti-Aging Effects of Calorie Restriction / Suresh I.S. Rattan and Dino Demirovic
Part 3. CALORIE RESTRICTION IN THE CLINICAL SETTING
Calorie Restriction and Obesity / Krista A. Varady
Caloric Restriction and Cardiovascular Disease / Anna Csiszar, Rafael de Cabo and Zoltan Ungvari
The Effect of Caloric Restriction on Physiological, Psychological and Behavioral Outcomes in Humans: Results from CALERIE / Leanne M. Redman and Eric Ravussin
Calorie Restriction and Cancer: An Update / Robin K. Minor, R. Michael Anson and Rafael de Cabo
Conclusion: Human Calorie Restriction and Anti-aging Therapy / Arthur V. Everitt, Leonie K. Heilbronn, Brian J. Morris, Holly M. Brown-Borg and Brian J. Merry, et al.Digital Access Springer 2010 - ArticleWold B, Wigler M, Lacy E, Maniatis T, Silverstein S, Axel R.Proc Natl Acad Sci U S A. 1979 Nov;76(11):5684-8.The cloned chromosomal rabbit beta-globin gene has been introduced into mouse fibroblasts by DNA-mediated gene transfer (transformation). In this report, we examine the expression of the rabbit gene in six independent transformants that contain from 1 to 20 copies of the cloned globin gene. Rabbit globin transcripts were detected in two of these transformants at steady-state concentrations of 5 and 2 copies per cell. The globin transcripts from one cell line are polyadenylylated and migrate as 9S RNA on methylmercury gels. These transcripts reflect correct processing of the two intervening sequences but lack 48 +/- 5 nucleotides present at the 5' terminus of rabbit erythrocyte globin mRNA.