BookGreg H. Enders, editor.
Contents:
Part I: Starting the Cell Division Cycle
1 Escape from Cellular Quiescence
2 Interplay Between Cyclin-Dependent Kinases and E2F-Dependent Transcription
3 Regulation of Pre-RC Assembly: A Complex Symphony Orchestrated by CDKs
Part II: Proliferation Under Duress
4 Mitotic Checkpoint and Chromosome Instability in Cancer
5 Mitotic Catastrophe
6 p53, ARF, and the Control of Autophagy
Part III: Long-Term Proliferation
7 Regulation of Self-Renewing Divisions in Normal and Leukaemia Stem Cells
8 Maintenance of Telomeres in Cancer
9 The Senescence Secretome and Its Impact on Tumor Suppression and Cancer
Part IV: Applications in Preventing and Treating Cancer
10 Cell Cycle Deregulation in Pre-neoplasia: Case Study of Barrett8217;s Oesophagus
11 Targeting Cyclin-Dependent Kinases for Cancer Therapy
Index.