Today's Hours: 8:00am - 10:00pm
Lane Medical Library

Search

Filter Results

Did You Mean:

Search Results

Sort by
relevance
  • Journal
    Digital Access
    Provider
    Version
    Ovid
    v. 47-, 1994-
    Lippincott
    v. 47-, 1994-
  • Article
    Seshadri M, Poduval TB, Sundaram K.
    J Natl Cancer Inst. 1979 Nov;63(5):1205-10.
    A normally nonmetastatic tumor metastasized to the regional axillary lymph nodes following severe immunosuppression of inbred Swiss mice. The extent of metastasis was dependent on the severity of lymphocyte depletion and the initial number of tumor cells injected. Sensitization of the host to the tumor was important in prevention of metastasis: Metastasis was induced only if the immunosuppressive treatment occurred within 3 days of tumor inoculation. Antitumor immunity was adoptively transferred by the splenocytes from animals given immunosuppressive treatment with X-rays or hydrocortisone acetate on day 14. Though spleen cells from animals given both immunosuppressants did not have this property, that no metastasis was observed even in doubly immunosuppressed mice indicated sensitization to tumor cells. Lymphocyte number was important also: Injection of splenocytes from normal to tumor-bearing animals significantly reduced the occurrence of metastases.
    Digital Access Access Options