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  • Book
    edited by Leonard G. Feld, Frederick J. Kaskel.
    Digital Access Springer 2010
  • Article
    Linsenmayer TF, Hendrix MJ, Little CD.
    Proc Natl Acad Sci U S A. 1979 Aug;76(8):3703-7.
    We have shown that lymphocyte-myeloma cell hybridization can be used to produce large amounts of extremely high-titer specific antibodies against type I collagen, a macromolecule normally of low immunogenicity. In a passive hemagglutination assay the antibody had a high titer against chicken type I collagen but showed no activity against chicken type II or rat type I collagen. By using a two-step fluorescence histochemical procedure on sections of embryonic chicken tibia, strong fluorescence was observed in the perichondrium and surrounding connective tissue (known to contain type I collagen) but not over the cartilage (characterized by type II collagen). When used in conjunction with Staphylococcus aureus as a solid phase immunoadsorbant, the antibody was shown to bind to labeled collagen synthesized in vitro by embryonic chicken calvaria.
    Digital Access Access Options