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- ArticleLucas MS, Moore DJ.J Prosthet Dent. 1979 Oct;42(4):447-51.A new silicone material, Silastic MDX 4-4210, was tested by tissue culture and tissue implantation to compare host reaction with known toxic and nontoxic materials. It was not found to be toxic to a monolayer of HEL cells, and it evoked a minimal foreign body reaction when implanted in albino rats. Further clinical studies are indicated to evaluate host reaction of this silicone in long-term contact with human mucous membrane and skin tissue.