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- ArticleRamazzotto LJ, Carlin RD, Warchalowski GA.J Dent Res. 1979 Sep;58(9):1940-3.Susceptibility of the pregnant female rat to possible teratogenic effects from acute nitrous oxide exposure was studied. A statistically significant increase in fetal death rate (ranging from 19.1 to 7%) was observed with exposure during various periods of organogensis. No significant differences in fetal length, weight, or organ-to-body-weight ratio for spleen and liver were observed.