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  • Journal
    Digital Access
    Provider
    Version
    Wiley
    v. 1-, 1955-
    PEP Archive
    v. 1-, 1955- Full text delayed 3+ years
    Acad Search Prem
    v. 1-, 1955- Full text delayed 12 months
    Print Access Request
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    Version
    Call Number
    Items
    Stored offsite. Please request print.
    v. 1-23, 1955-78.
    13
  • Article
    Goldstein L, Boylan JM, Boyd TA.
    Curr Probl Clin Biochem. 1977 Oct 23-26;8:273-9.
    alpha-Ketoglutarate (KG) is a potent inhibitor of renal mitochondrial glutamine transport and deamidation at physiological concentrations. The concentration-inhibition relationship observed between KG and mitochondrial glutamine transport and deamidation indicates that changes in renal KG concentration occurring during alterations in acid-base balance would have significant effects on mitochondrial ammonia production in vivo. A rapid-mixing, rapid-filtration method was developed to measure the effects of KG on initial rates of mitochondrial glutamine transport. Transport was linear for only a few seconds and approached steady-state conditions by 30 seconds. KG (0.3 mM) raised the glutamine transport Km approximately two-fold. We propose that KG may play a major regulatory role in the early adaptation of renal ammonia production to acidosis.
    Digital Access Access Options