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  • Book
    Barry Mitchell, Ram Sharma ; illustrations by Robert Britton.
    Contents:
    How does an embryo form?
    How do the placenta and fetal membranes form?
    The body cavities and the diaphragm
    The integumentary, skeletal, and muscular systems
    The respiratory system
    The cardiovascular system
    The digestive system
    The urinary system
    The reproductive system
    The nervous system
    Development of the head and neck, the eye, and the ear.
    Digital Access ScienceDirect 2009
    Print Access Request
    Location
    Version
    Call Number
    Items
    Books: General Collection (Downstairs)
    2009
    QM601 .M668 2009
    1
  • Article
    Patel DJ, Canuel LL, Pohl FM.
    Proc Natl Acad Sci U S A. 1979 Jun;76(6):2508-11.
    The high resolution 1H and 31P NMR spectra of the (dG-dC)8 duplex have been recorded in low- and high-salt solutions in order to evaluate the structural aspects of the salt-induced transition of oligo(dG-dC) in solution [Pohl, F. M. & Jovin, T. M. (1972) J. Mol. Biol. 67, 375-396]. The NMR data require that the (dG-dC)8 duplex in 4 M NaCl adopt an "alternating B-DNA" conformation for which the symmetry unit repeats every two base pairs. By contrast, the oligomer duplex in low-salt solution is of the regular B-DNA type in solution. The chemical shift parameters for oligo(dG-dC) in high-salt solution demonstrate that every other glycosidic torsion angle and phosphodiester linkage adopts a different conformation from that observed in regular B-DNA. We demonstrate further that the generation of the "alternating B-DNA" structure is facilitated by introduction of halogen atoms at the 5 position of pyrimidine and that this probably reflects the greater overlap of this position with adjacent base pairs in high salt solution. An "alternating B-DNA" model has recently been proposed for alternating deoxy purine-deoxy pyrimidine polynucleotides based on the x-ray structure of pdA-dT-dA-dT [Klug, A., Jack, A., Viswamitra, M.A., Kennard, O., Shakked, Z. & Steitz, T.A. (1979) J. Mol. Biol., in press].
    Digital Access Access Options