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  • Journal
    Digital Access
    Provider
    Version
    TandFonline
    v. 1-48, 1970-2011.
    Acad Search Prem
    v. 39-, 2002- Full text delayed 18 months
    CINAHL
    v. 45-, 2008- Full text delayed 18 months
    Print Access Request
    Location
    Version
    Call Number
    Items
    Stored offsite. Please request print.
    v. [1], 2-27, 30-36, [1970], 1971-89, 1993-99.
    23
  • Article
    Singh RC, Srivastava VK, Tayal G, Srivastava RK, Prasad DN.
    Indian J Physiol Pharmacol. 1978 Jan-Mar;22(1):61-5.
    Interaction of insulin with beta-adrenoceptor antagonists was studied in conscious rabbits. Propranolol and metoprolol did not modify the peak of insulin hypoglycaemia but delayed its recovery. Practolol, sotalol and 1-INPEA enhanced the peak effect and delayed the recovery of insulin-induced hypoglycaemia. H 35/25 and d-INPEA did not modify insulin hypoglycaemia. The beta-blockers did not produce significant hypoglycaemia per se. Since sotalol, 1-INPEA (specific beta-adrenoceptor antagonists devoid of local anaesthetic activity); practolol and metoprolol (selective cardiac beta-1 adrenoceptor antagonists) enhanced hypoglycaemic action of insulin and H 35/25 (a selective beta-2 adrenoceptor antagonist) failed to affect it, it seems that selective beta-adrenoceptor blockade (similar to cardiac beta-1 adrenoceptors) mediates enhancement of insulin hypoglycaemia. Caution should, therefore, be exercised in administering beta-adrenoceptor antagonists and insulin together. A reduction in the dose of insulin may be necessary.
    Digital Access Access Options