Search

Search Results

• Database

  Chemical Abstracts Service Source Index

  Digital Access Am Chem Soc 1907-

  Print Access Request

  Location

  Version

  Call Number

  Items

  Retired Reference Periodicals (Downstairs)

  1907/79-1907/2004.

  12
  Get Shareable Link

  View Details
• Article

  Pharmacokinetics of sulphamethoxazole in man: effects of urinary pH and urine flow on metabolism and renal excretion of sulphamethoxazole and its metabolite N4-acetylsulphamethoxazole.

  Vree TB, Hekster YA, Baars AM, Damsma JE, van der Kleijn E.

  Clin Pharmacokinet. 1978 Jul-Aug;3(4):319-29.

  A high performance liquid chromatography method for the determination of sulphamethoxazole and its metabolite N4-acetylsulphamethoxazole is described. The renal excretion rate and cumulative renal excretion of sulphamethoxazole is markedly influenced by urinary pH. With constant urinary pH, the renal excretion rate and the renal clearance of sulphamethoxazole is dependent on the urine flow. The renal clearance of the metabolite N4-acetylsulphamethoxazole is not influenced by urinary pH or urine flow. No clear acetylator phenotype could be detected in the group of volunteers studied. The extent of acetylation depends on the amount of sulphamethoxazole available for acetylation, thus indirectly on the urine pH and flow.

  Digital Access Access Options
  Get Shareable Link

  PubMed