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  • Book
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    Periodicals (Downstairs)
    no. 2-5, 8-18, 20-41, 43-73, 1928-37, 1954-70, 1971-86, 1988-2005.
    REPORTS PRIOR TO NO. 8 NOT SHELVED UNDER PERIODICAL TITLE; SEE RECORDS FOR INDIVIDUAL REPORTS FOR LOCATIONS. No. 64-73 shelved with Journal of the ICRU.
    9
  • Article
    Barrett AM, McSharry L.
    J Pharm Pharmacol. 1975 Dec;27(12):889-95.
    Iproniazid was found to reduce food consumption in fasting rats. Combined treatment of iproniazid with tryptophan resulted in a significantly greater anorexic action whilst tryptophan alone had no effect on food consumption. Iproniazid treatment was associated with a significant increase in brain 5-hydroxytryptamine (5-HT) concentration but in association with tryptophan higher brain 5-HT concentrations were recorded. The anorexic action of the iproniazid-tryptophan combination was antagonized in a dose-dependent fashion by methysergide. Equivalent levels of anorexia induced by fenfluramine and mazindol were similarly antagonized by methysergide in a dose-related manner. The results suggest a common role of 5-HT in the inhibition of eating behaviour in fasting rats when anorexia is induced by iproniazid, fenfluramine or mazindol, sensitive to a specific 5-HT antagonist.
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