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  • Book
    Stedman, Thomas Lathrop.
    Digital Access STAT!Ref 2016
    Print Access
    Location
    Version
    Call Number
    Items
    Reference (Upstairs)
    2000-06.
    R121 .S8
    6
    Retired Reference (Downstairs)
    1930, 1936, 1946, 1957-61, 1972-2000
    R121 .S8
    13
    Request
    Stored offsite. Please request print.
    1914, 1918, 1925.
    H121 .S81
    3
    Request
  • Article
    Aggerbeck M, Guellaen G, Hanoune J.
    Br J Pharmacol. 1978 Apr;62(4):543-8.
    1 Labetalol (AH 5158A) inhibited the adrenaline-stimulated adenylate cyclase activity of rat liver and heart. This drug had no effect on basal or guanosine triphosphate (GTP)-activated adenylate cyclase activities. 2 Labetalol displaced the binding of the specific ligands [3H]-dihydroergocryptine and (-)-[3H]-dihydroalprenolol from their respective alpha and beta-adrenoceptors in rat heart and liver. The affinity of labetalol was 10 fold higher for the beta- than for the alpha-adrenoceptor. It appeared to be 10 to 100 times less potent than phentolamine in blocking alpha-adrenoceptors and 5 to 10 times less potent than propranolol in blocking beta-receptors. 3 It is concluded that labetalol exerts its dual alpha- and beta-antagonism by acting directly on the plasma membranes, where it binds competitively to alpha- and beta-adrenoceptors.
    Digital Access Access Options