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  • Book
    Division of Health Resources Utilization Statistics.
    Digital Access
    Provider
    Version
    Google Books
    Fulltext (1974 publ.1977)
    Google Books
    Fulltext (1975 publ.1977)
    Print Access Request
    Location
    Version
    Call Number
    Items
    Stored offsite. Please request print.
    1977-
    RA407.3 .N27
    2
  • Article
    Feldman M, Richardson CT.
    Adv Intern Med. 1978;23:1-24.
    Development of histamine H2-receptor antagonists has enhanced the understanding of histamine physiology and pharmacology. The effect of H2-receptor antagonists on gastrointestinal physiology has been studied extensively. These compounds inhibit gastric acid secretion in response to all known secretagogues and, in contrast to anticholinergic drugs, markedly inhibit food-stimulated acid secretion in duodenal ulcer patients. The relative roles of H2-receptor antagonists, anticholinergic drugs and antacids in the treatment of duodenal ulcer remain to be defined. Cimetidine currently is under investigation for the treatment of duodenal ulcer, gastric ulcer, reflux esophagitis, gastrointestinal bleeding and hypersecretory states. Although the long-term safety of cimetidine has not been established, in short-term clinical trials there have been no significant subjective or objective side-effects. Assuming that toxic effects do not develop, H2-receptor antagonists should improve the treatment of acid-peptic disease.
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