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- JournalDigital Access Wiley v. 6-66, 1986-2009.
- ArticleNaquira D, Zunino E, Arqueros L, Viveros H.Eur J Pharmacol. 1978 Jan 15;47(2):227-9.The effects of chronic administration of nicotine upon catecholamine (CA) synthesizing enzymes of rat hypothalamus, striatum and adrenal medulla were studied. Nicotine 3 mg/kg/day for 14 days, increased tyrosine hydroxylase (TH) and dopamine-beta-hydroxylase (DBH) in hypothalamus and adrenal medulla but did change striatum TH. The data suggest that chronic nicotine administration can produce similar long-term alterations in both of the main CA forming enzymes in the hypothalamus and in adrenal medulla.