Search
Filter Results
- Resource Type
- Article1
- Journal1
- Journal Digital1
- Result From
- Lane Catalog1
- PubMed1
-
Year
- Journal Title
- J Clin Invest1
Search Results
Sort by
- ArticleNakao K, Nakai Y, Oki S, Horii K, Imura H.J Clin Invest. 1978 Dec;62(6):1395-8.To elucidate whether or not beta-endorphin exists in plasma of normal subjects, plasma extracts obtained before and after metyrapone administration were subjected to gel exclusion chromatography, and fractions obtained were assayed by a sensitive radioimmunoassay for beta-endorphin. The basal plasma level of beta-endorphin was 5.8 +/- 1.1 pg/ml (mean +/- SE, n = 5), which rose significantly to the level of 48.9 +/- 3.8 pg/ml after a single oral dose (30 mg/kg of body wt) of metyrapone administration (P less than 0.001). Plasma ACTH levels also increased from the mean basal level of 73 +/- 4 pg/ml to 269 +/- 41 pg/ml after metyrapone administration. These results indicate that beta-endorphin, distinct from beta-lipotropin, exists in normal human plasma and that it is released from the pituitary concomitantly with ACTH.