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• Book

  Arthritis and allied conditions : a textbook of rheumatology. 15th ed.

  edited by William J. Koopman and Larry W. Moreland.

  Contents:
  Sect. I. Introduction to the study of the rheumatic diseases
  Sect. II. Scientific basis for the study of the rheumatic diseases
  Sect. III. Therapeutic approaches in the rheumatic diseases
  Sect. IV. Surgical intervention in the rheumatic diseases
  Sect. V. Rheumatoid arthritis
  Sect. VI. Other inflammatory arthritis syndromes
  Sect. VII. Systemic rheumatic diseases
  Sect. VIII. Vasculitis and related diseases
  Sect. IX. Miscellaneous rheumatic diseases
  Sect. X. Regional disorders of joints and related structures
  Sect. XI. Osteoarthritis
  Sect. XII. Metabolic bone and joint diseases
  Sect. XIII. Infectious arthritis.

  Digital Access Ovid 2005

  Print Access Request

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  Items

  Books: General Collection (Downstairs)

  v. 1-2, 2005.

  RC933 .A64 2005

  2
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• Article

  Unspecific and specific stimulating effects of 3',5'-cyclic nucleotides (cGMP, cAMP, cIMP, cCMP) on the in vitro biosynthesis of proteochondroitin-4,-6-sulfate and on other anabolic processes from calf rib cartilage.

  Kleine TO, Schippers K.

  Agents Actions. 1978 Dec;8(6):636-43.

  With cartilage slices from calf ribs, cGMP as well as cAMP accelerate dose-dependently and specifically label rates of Ch-4-,-6-S protein; they slightly elevate rates of anaerobic glycolysis dose-independently and unspecifically, similar to their 5-monophosphate compounds. cAMP, but not cGMP, slightly stimulates labeling of total protein dose-dependently. Guanosine and adenosine (as well as adenine) accelerate more significantly all three anabolic processes in the order Ch-4-,-6-S protein formation greater than or equal to total protein labeling greater than anaerobic glycolysis. Acceleration of some of the processes rises further after adding theophylline or SQ 20.009, depending on the nucleoside used. diBu-cAMP (but not 8-Br-cAMP) stimulates the three processes more than cAMP; diBu-cGMP and 8-Br-cGMP alone increase the labeling rates of protein more than cGMP, cCMP and cIMP slightly accelerate at least one of the three processes dose-independently and unspecifically, similar to their 5-monophosphate compounds. cUMP was almost inactive. The results point to specific and unspecific effects of cGMP similar or different to those of cAMP.

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  PubMed