Search
Filter Results
- Resource Type
- Article1
- Book1
- Book Print1
- Journal1
- Result From
- Lane Catalog1
- PubMed1
- SearchWorks (biomedical subset) 1
-
Year
- Journal Title
- Infect Immun1
Search Results
Sort by
- JournalDigital AccessProviderVersionSpringerPubMed Centralv. 31-, 2011- Full text delayed 12 monthsKSMCBAcad Search Prem
- ArticleKlein TW, Pross SH, Benjamin WR.Infect Immun. 1978 Dec;22(3):778-85.Bordetella pertussis and Corynebacterium parvum are commonly used immunopotentiating agents. To explore the inflammatory environment induced by these agents, the peritoneal exudate response in mice following intraperitoneal injection of B. pertussis (PV) and C. parvum (CV) vaccines was investigated. The PV-induced exudate isolated by lavage was characterized by an early neutrophil influx followed by enhanced accumulation of mononuclear cells and fluid protein. The CV exudate was principally mononuclear in nature and displayed fewer numbers of cells and less fluid protein. Both vaccines also enhanced the leukocyte adherence inhibitory activity (LAIA) of peritoneal fluid as measured in vitro. The development of exudate LAIA was T lymphocyte independent. A similar LAIA was demonstrated in nonimmune mouse plasma and serum. Exudate fluid and serum LAIA were heat stable and trypsin sensitive. These studies suggest that significant differences exist in the composition of the local tissue environment following PV and CV injection and that exudate LAIA is serum derived. Further studies in this direction should result in a better understanding of the ways in which inflammatory cells and fluid substances affect lymphocyte-macrophage interaction subsequent to adjuvant administration.
- Bookby Senator J. W. Fulbright ; an address delivered at a special meeting sponsored by the American Bar Association, Honolulu, August 8, 1967.Print 1967