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  • Book
    Abraham, Donald J.; Burger, Alfred; Rotella, David P.
    Summary: "... provides an established, recognized, authoritative and comprehensive source on medicinal chemistry and drug discovery and development. This flagship reference for medicinal chemists and pharmaceutical professions has been thoroughly updated and expanded across 8 volumes to incorporate the entire process of drug development (preclinical testing, clinical trials, etc.) alongside the traditional strengths in medicinal chemistry and drug discovery"--Provided by publisher.

    Contents:
    Autocoids, Diagnostics, and Drugs from New Biology
    Chemotherapeutic Agents
    Drug Discovery/Development
    Nervous System Agents.
    Digital Access Wiley 2010
  • Article
    Cha YN.
    Am J Trop Med Hyg. 1978 Nov;27(6):1181-7.
    The activities of some hepatic microsomal drug metabolizing enzymes, which are markedly depressed in mice infected with Schistosoma mansoni, can be increased by treatment with phenobarbital or 3-methylcholanthrene. Administration of these compounds to infected mice increased the capacity of the liver to metabolize drugs up to the maximum level inducible in non-infected animals. However, the increased hepatic microsomal mass, reflected in glucose 6-phosphatase activities and cytochrome b5 levels, observed in schistosome-infected mice, was not increased further by the same treatment. The changes in the activities of several drug metabolizing enzymes in vitro were confirmed in vivo by determination of hexobarbital-induced sleeping time and zoxazolamine-induced paralysis duration.
    Digital Access Access Options