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  The International Journal of Social Psychiatry

  Digital Access Sage v. 1-, 1955-

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  v. 1-51, 1955-2005.

  34
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• Article

  Brain tyrosine level controls striatal dopamine synthesis in haloperidol-treated rats.

  Scally MC, Ulus I, Wurtman RJ.

  J Neural Transm. 1977;41(1):1-6.

  Animals received either haloperidol (2 mg/kg) or probenecid (200 mg/kg) in conjunction with tyrosine (100 mg/kg) or its diluent. Striatal homovanillic acid levels increased in probenecid-treated animals to the same range whether they were given tyrosine or not. In haloperidol-treated animals the levels of homovanillic acid were significantly elevated in animals receiving tyrosine. Tyrosine and homovanillic acid levels were highly correlated as determined by linear regression analysis.

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