Search

Search Results

• Journal

  Applied microbiology and biotechnology

  Digital Access

  Provider

  Version

  Springer

  v. 19-, 1984-

  Acad Search Prem

  v. 62-, 2003- Full text delayed 12 months

  Print Access Request

  Location

  Version

  Call Number

  Items

  Stored offsite. Please request print.

  v. 19-33, 1984-90.

  15
  Get Shareable Link

  View Details
• Article

  The interaction between clonidine and various neuroleptic agents and some benzodiazepine tranquillizers.

  van Zwieten PA.

  J Pharm Pharmacol. 1977 Apr;29(4):229-34.

  The central hypotensive action of clonidine, infused into the vertebral artery of chloralose-anaesthetized cats was antagonized by several phenothiazine-neuroleptics (chlorpromazine, promazine, promethazine, thiethylperazine, thioridazine), by chlorprothixene and to a limited extent by haloperidol administered via the same route. Pimozide and some benzodiazepines (chlordiazepoxide, diazepam and flurazepam) hardly influenced the central hypotensive response to clonidine. The antagonism between clonidine and the psychotropic drugs is probably associated with central alpha-adrenoceptors, clonidine being the agonist and the neuroleptic agents the antagonists at these receptors. Virtually the same type of antagonism was observed in conscious, spontaneously hypertensive rats where both clonidine and the neuroleptic drugs were injected intravenously. The phenothiazines and also piperoxane effectively diminished the centrally induced hypotensive response to clonidine, whereas the initial pressor effect to clonidine was not reduced.

  Digital Access Access Options
  Get Shareable Link

  PubMed