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  • Book
    M.J. Harrison, T.E.J. Healy, J.A. Thornton.
    Contents:
    pt. 1. The Basic sciences
    pt. 2. Clinical practice.
    Print Access Request
    Location
    Version
    Call Number
    Items
    Books: General Collection (Downstairs)
    v. 1, 1984
    RD82.2 .H37
    1
  • Article
    Barnes WR, Dorn GL, Vela GR.
    Appl Environ Microbiol. 1977 Feb;33(2):257-61.
    The nutritional requirements and culture conditions affecting biosynthesis of L-asparaginase in a mutant of Escherichia coli HAP designated strain A-1 were studied. Asparaginase activity was increased by the addition of L-glutamic acid, L-glutamine, or commercial-grade monosodium glutamate. The rate of enzyme synthesis was dependent on the interaction between the pH of the culture and the amount of oxygen dissolved in the medium. A critical oxygen transfer rate essential for asparaginase formation was identified, and a fermentation procedure is described in which enzyme synthesis is controlled by aeration rate. Enhancement of L-asparaginase activity by monosodium glutamate was inhibited by the presence of glucose, culture pH, chloramphenicol, and oxygen dissolved in the fermentation medium.
    Digital Access Access Options