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- ArticleDupont J, Dupont JC, Milon H, Froment A.C R Acad Hebd Seances Acad Sci D. 1975 Apr 07;280(13):1637-40.We have observed a high and significant mortality in spontaneously hypertensive rats compared to normotensive and hypotensive controls, in the fifth generation. The hypertensive rats exhibited a high frequency of cerebral haemorrhage and periarteritis nodosa.