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- ArticleAlmeida HO, Tafuri WL, Cunha-Melo JR, Freire-Maia L, Raso P, Brener Z.Virchows Arch A Pathol Anat Histol. 1977 Dec 08;376(4):353-60.A dramatic reduction in the total number of dense vesicles in Auerbach's plexus of the mouse colon was observed during the acute phase of experimental American Trypanosomiasis (Chagas' disease). A significant decrease in substance P activity of the colon of inoculated animals was also measured. It is suggested that this decrease in substance P activity could be related to the reduction in the number of dense vesicles in Auerbach's plexus.