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- ArticleMeerson FZ.Kardiologiia. 1975 Oct;15(10):17-23.The mechanism limiting the function of a normal heart is considered and the key part played in it by the system of an active ionic transport of the myocardial cell is pointed out. With an excessive load on the heart and also in cases of hypoxic and other lesions of the heart muscle--the mechanism limiting the cardiac function becomes the main causative factor of cardiac insufficiency.