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- ArticleMuster D, Karcher-Djuricic V, Ruch JV.C R Seances Soc Biol Fil. 1975;169(6):1599-604.The authors have studied the effects of insulin at various concentrations on in vitro cultivated dental rudiments. They observed histologic lesions generated by edema, neither anticipated cellular differentiation nor stimulation of collagen secretion, decrease of mitotic activity, but stimulation of thymidine 3H incorporation after short contact times.