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  • Article
    Skoog P, Ohlsson M, Fernö M, Rydén L, Borrebaeck CAK, Wingren C.
    PLoS One. 2017;12(6):e0179775.
    Histological grade is one of the most commonly used prognostic factors for patients diagnosed with breast cancer. However, conventional grading has proven technically challenging, and up to 60% of the tumors are classified as histological grade 2, which represents a heterogeneous cohort less informative for clinical decision making. In an attempt to study and extend the molecular puzzle of histologically graded breast cancer, we have in this pilot project searched for additional protein biomarkers in a new space of the proteome. To this end, we have for the first time performed protein expression profiling of breast cancer tumor tissue, using recombinant antibody microarrays, targeting mainly immunoregulatory proteins. Thus, we have explored the immune system as a disease-specific sensor (clinical immunoproteomics). Uniquely, the results showed that several biologically relevant proteins reflecting histological grade could be delineated. In more detail, the tentative biomarker panels could be used to i) build a candidate model classifying grade 1 vs. grade 3 tumors, ii) demonstrate the molecular heterogeneity among grade 2 tumors, and iii) potentially re-classify several of the grade 2 tumors to more like grade 1 or grade 3 tumors. This could, in the long-term run, lead to improved prognosis, by which the patients could benefit from improved tailored care.
    Digital Access Access Options
  • Book
    [edited by] Friedrich Paulsen, Jens Waschke ; translated by, T. Klonisch and S. Hombach-Klonisch.
    Summary: "The Sobotta Atlas shows authentic illustrations of the highest quality, drawn from genuine specimens, guaranteeing the best preparation for the gross anatomy class and attestation. Sobotta focuses on the basics, making it comprehensive. Every tiny structure has been addressed according to current scientific knowledge and can be found in this atlas"-- publisher's description.

    Contents:
    Organs of the thoracic cavity
    Organs of the abdominal cavity
    Retroperitoneal space and pelvic cavity.
    Digital Access ClinicalKey 2022