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  • Article
    Barnard S, Marshall-Pescini S, Passalacqua C, Beghelli V, Capra A, Normando S, Pelosi A, Valsecchi P.
    PLoS One. 2016;11(3):e0149831.
    A number of studies have recently investigated personality traits in non-human species, with the dog gaining popularity as a subject species for research in this area. Recent research has shown the consistency of personality traits across both context and time for adult dogs, both when using questionnaire based methods of investigation and behavioural analyses of the dogs' behaviour. However, only a few studies have assessed the correspondence between these two methods, with results varying considerably across studies. Furthermore, most studies have focused on adult dogs, despite the fact that an understanding of personality traits in young puppies may be important for research focusing on the genetic basis of personality traits. In the current study, we sought to evaluate the correspondence between a questionnaire based method and the in depth analyses of the behaviour of 2-month old puppies in an open-field test in which a number of both social and non-social stimuli were presented to the subjects. We further evaluated consistency of traits over time by re-testing a subset of puppies. The correspondence between methods was high and test- retest consistency (for the main trait) was also good using both evaluation methods. Results showed clear factors referring to the two main personality traits 'extroversion,' (i.e. the enthusiastic, exuberant approach to the stimuli) and 'neuroticism,' (i.e. the more cautious and fearful approach to the stimuli), potentially similar to the shyness-boldness dimension found in previous studies. Furthermore, both methods identified an 'amicability' dimension, expressing the positive interactions the pups directed at the humans stranger, and a 'reservedness' dimension which identified pups who largely chose not to interact with the stimuli, and were defined as quiet and not nosey in the questionnaire.
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  • Article
    Lv A, Qi S, Wang G.
    Sci Total Environ. 2022 Jan 01;802:149831.
    Quantifying the climatic and anthropogenic effects on hydrological processes has received considerable attention. However, diverse conclusions could be drawn when different models and forcing datasets are used. This is particularly uncertain and challenging in poorly gauged arid regions. Here we aim to tackle this issue in the poorly gauged Xiangride River Basin within the Qaidam Basin, one of the three prominent inland basins in China. We applied two distinct models (Budyko Mezentsev-Choudhurdy-Yang and process-based SWAT) to a poorly-gauged inland basin in West China. The model simulations were driven by four precipitation products including Tropical Rainfall Measuring Mission (TRMM) 3B42 V7, Global Precipitation Measurement (GPM) IMERG V6, Multi-Source Weighted-Ensemble Precipitation (MSWEP) and China Meteorological Assimilation Driving Datasets (CMADS). Our results indicate that MSWEP performed best (NSE = 0.64 vs. 0.36-0.59 for other datasets) in the baseline period (2009-2012), whereas CMADS was more accurate during the impacted period (2013-2016); CMADS and GPM might underestimate the precipitation in the baseline and impacted period, respectively. Hydrological processes during the impacted period are presumed to be influenced by climate variation and/or human activities, compared to the relatively natural status in the baseline period. We conclude that runoff decline between the two periods was mainly affected by human activities (-66 to 94%), whereas the contribution of climate variation was more likely positive. A literature survey reveals that major anthropogenic effects in the study area includes reservoir, road construction and cropland expansion that could lead to runoff decrease. We recommend the use of process-based model (e.g., SWAT) in studies like this, as process-based models driven by high-quality remote-sensed or reanalysis climate datasets, better represents the spatiotemporal hydrological change under altered conditions, whereas the steady-state assumption of soil water for the Budyko model may not be fully satisfied during a short period.
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  • Article
    Kimura G, Tagami A, Fukui R, Yaita M, Miyasaka T.
    Biochem Biophys Res Commun. 2024 05 21;709:149831.
    Asthma and chronic obstructive pulmonary disease (COPD) are respiratory diseases associated with airway inflammation, which is the main pathogenesis. Although their causes and characteristics differ, in some cases, asthma and COPD may coexist in the same patient in a condition called asthma-COPD overlap (ACO). The prognosis of ACO is more unfavourable than those of asthma or COPD alone, without any treatment strategies demonstrating efficacy. Owing to its intricate spectrum of features, the detailed pathogenesis of how ACO exacerbates respiratory features remains unclear. In this study, we exposed papain-induced asthma model mice to tobacco smoke to establish an ACO mouse model, in which features of airway inflammation observed in both asthma and COPD were incorporated. This model exhibited distinctive mixed and corticosteroid-resistant airway inflammation and emphysematous changes that are characteristic of ACO. The novel mouse model established here is expected to significantly contribute to elucidating the mechanisms of the broad pathologies of ACO and identifying potential therapeutic targets.
    Digital Access Access Options
  • Book
    Bruce M. Carlson.
    Summary: "Bruce Carlson's Human Embryology and Developmental Biology is one of the most detailed texts available for those who want to truly understand both the morphological and molecular aspects of human embryological development. Fully updated in its seventh edition, the book provides a thorough grounding in all aspects of embryology. It presents in detail the molecular and cellular basis for embryological processes, from early development through to development of body systems. It covers examples of congenital malformations and their underlying mechanisms, and comes complete with clinical vignettes and review questions to support learning. This book will suit medical and science students taking embryology courses as well as scientists and clinicians who find themselves returning to this topic throughout their careers"-- Provided by publisher.

    Contents:
    Getting Ready for Pregnancy
    Transport of Gametes and Fertilization
    Molecular Basis for Embryonic Development
    Cleavage and Implantation
    Formation of Germ Layers and Early Derivatives
    Establishment of the Basic Embryonic Body Plan
    Placenta and Extraembryonic Membranes
    Developmental Disorders: Causes, Mechanisms, and Patterns
    Integumentary, Skeletal, and Muscular Systems
    Limb Development
    Nervous System
    Neural Crest
    Sense Organs
    Head and Neck
    Digestive and Respiratory Systems and Body Cavities
    Urogenital System
    Cardiovascular System
    Fetal Period and Birth.
    Digital Access ClinicalKey [2023]