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  • Article
    Gonçalves OS, Santana MF.
    Gene. 2021 Apr 20;777:145476.
    Soil bacteria can rapidly adapt to environmental perturbations through horizontal gene transfer. Acidobacteria is one of the most persistent dominant phyla in the soil. However, the role of these organisms in terrestrial ecosystems remains elusive. Here we identified and describe the integrative and conjugative elements (ICEs) in the published complete genomes of Acidobacteria. In total, ten novel ICEs were identified, in which nine were found integrated as three separated monopartite ICEs in the single chromosome sequences of three Acidobacteria. These ICEs carry a repertoire of genes with potential environmental roles, including heavy metal resistance, iron uptake, secondary metabolism, and antibiotic resistance. To our knowledge, these are the first evidence of three monopartite ICEs identified in the single chromosome, and this might be due to the absence of recognizable entry exclusion systems. We hypothesis that the coexistence of multiples ICEs in the chromosome of Acidobacteria might reflect a major advantage for the survival, resistance, and persistence of phylum in the environment.
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  • Article
    Riley CM, Wenzel SE, Castro M, Erzurum SC, Chung KF, Fitzpatrick AM, Gaston B, Israel E, Moore WC, Bleecker ER, Calhoun WJ, Jarjour NN, Busse WW, Peters SP, Teague WG, Sorkness R, Holguin F.
    PLoS One. 2015;10(12):e0145476.
    INTRODUCTION: FEF25-75 is one of the standard results provided in spirometry reports; however, in adult asthmatics there is limited information on how this physiological measure relates to clinical or biological outcomes independently of the FEV1 or the FEV1/FVC ratio.
    PURPOSE: To determine the association between Hankinson's percent-predicted FEF25-75 (FEF25-75%) levels with changes in healthcare utilization, respiratory symptom frequency, and biomarkers of distal airway inflammation.
    METHODS: In participants enrolled in the Severe Asthma Research Program 1-2, we compared outcomes across FEF25-75% quartiles. Multivariable analyses were done to avoid confounding by demographic characteristics, FEV1, and the FEV1/FVC ratio. In a sensitivity analysis, we also compared outcomes across participants with FEF25-75% below the lower limit of normal (LLN) and FEV1/FVC above LLN.
    RESULTS: Subjects in the lowest FEF25-75% quartile had greater rates of healthcare utilization and higher exhaled nitric oxide and sputum eosinophils. In multivariable analysis, being in the lowest FEF25-75% quartile remained significantly associated with nocturnal symptoms (OR 3.0 [95%CI 1.3-6.9]), persistent symptoms (OR 3.3 [95%CI 1-11], ICU admission for asthma (3.7 [1.3-10.8]) and blood eosinophil % (0.18 [0.07, 0.29]). In the sensitivity analysis, those with FEF25-75% <LLN had significantly more nocturnal and persistent symptoms, emergency room visits, higher serum eosinophil levels and increased methacholine responsiveness.
    CONCLUSIONS: After controlling for demographic variables, FEV1 and FEV1/FVC, a reduced FEF25-75% is independently associated with previous ICU admission, persistent symptoms, nocturnal symptoms, blood eosinophilia and bronchial hyperreactivity. This suggests that in some asthmatics, a reduced FEF25-75% is an independent biomarker for more severe asthma.
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  • Article
    Wang Y, Gu X, Quan J, Xing G, Yang L, Zhao C, Wu P, Zhao F, Hu B, Hu Y.
    Sci Total Environ. 2021 Jun 15;773:145476.
    Magnetic field (MF) has been applied widely and successfully as an efficient, low-cost and easy-to-use technique to enhance wastewater treatment (WWT) performance. Although the effects of MF on WWT were revealed and summarized by some works, they are still mysterious and complex. This review summarizes the application of MF in magnetic adsorption-separation of heavy metals and dyes, treatment of domestic wastewater and photo-magnetic coupling technology. Furthermore, the mechanisms of MF-enhanced WWT are critically elaborated from the perspective of magnetic physicochemical and biological effects, such as magnetoresistance, Lorentz force, and intracellular radical pair mechanism. At last, the challenges and opportunities for MF application in WWT are discussed. For overcoming the limitations and taking advantages of MFs in WWT, fundamental research of the mechanisms of the application of MFs should be carried out in the future.
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  • Book
    editors, Julie Miller and Mary Stahl.
    Summary: "AACN Tele-critical Care Nursing Practice: An Expert Consensus Statement Supporting Acute, Progressive and Critical Care 2022 provides hospitals, leaders, and nurses with recommendations, clinical vignettes, and a framework to implement, evaluate, and improve their evolving practice. This new statement explores the many practice changes and keeps pace with expanding applications in this area of telemedicine, and supports the terminology shift to tele-critical care. It identifies essential tele-critical care elements, reflects current evidence, and delivers a fresh perspective to this fast-growing area of healthcare. The 2021 tele-critical care nursing expert consensus statement task force brought together tele-critical care nursing leaders from diverse backgrounds to share best practices, evidence, and lessons learned. The expertise and dynamic, front-line viewpoint of these experts has resulted in a comprehensive, patient-centric update. Their experience delivering both on-site direct care and remote care was instrumental in developing clinical vignettes and outlining key tele-critical care nursing interventions. The vignettes are real-world examples of how each key recommendation is implemented to provide continuity of care; demonstrate the value of tele-critical care nursing for a strong return on investment; identify high-risk patients; and decrease mortality rates by leveraging clinician expertise and technology, and partnering with on-site nurses to provide expert evidence-based care"-- Publisher's description.

    Contents:
    Introduction
    Purpose --Conceptual frameworks
    AACN tele-critical care nursing practice model
    AACN tele-critical care nursing practice recommendations
    Conclusions.
    Digital Access ClinicalKey Nursing 2022