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  • Article
    Zhu L, Huang S, Li J, Chen J, Yao Y, Li L, Guo H, Xiang X, Deng J, Xiong J.
    Gene. 2020 Jun 05;742:144556.
    BACKGROUND: Sophoridine, a quinolizidine alkaloid extracted from the Chinese herb Sophora alopecuroides L., has been reported to exert antitumor effects against multiple human cancers. However, few studies have evaluated its tumor-suppressing effects and associated mechanism with respect to lung cancer, in addition to its potential to be used for clinical lung cancer treatment.
    METHODS: Different types of lung cancer cells were used to investigate the antitumor effects of sophoridine using cell viability, colony formation, and cell invasion, and migration assays. To determine the signaling pathways involved, western blot analysis, quantitative real-time polymerase chain reaction, an in vivo ubiquitination assay, and immunohistochemistry were used in cellular assays and with a subcutaneous xenograft model in BALB/c mice.
    RESULTS: Sophoridine significantly suppressed the proliferation of and colony formation by lung cancer cells in vitro. Transwell assays demonstrated that sophoridine also inhibited invasion and migration in lung cancer cells. In addition, sophoridine enhanced the effects of cisplatin on lung cancer cells. A mechanistic study revealed that sophoridine significantly activated the Hippo and p53 signaling pathways, and mouse xenograft experiments further confirmed in vitro findings in lung cancer cells.
    CONCLUSIONS: Taken together, these results suggest that sophoridine can inhibit lung cancer progression and enhance the effects of the anticancer drug cisplatin against lung cancer cells. The mechanism of action of sophoridine might involve the Hippo and p53 signaling pathways.
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  • Article
    Zhao W, Yu G, Blaney L, Wang B.
    Sci Total Environ. 2021 May 15;769:144556.
    Due to the potential ecological and human health risks, pharmaceuticals and personal care products (PPCPs) are considered as contaminants of emerging concern. PPCPs can be discharged to the aquatic environment from various sources, including municipal wastewater treatment plants (WWTPs), animal feeding operations, hospitals, and pharmaceutical manufacturers. A major challenge to regional characterization of ecological and human health risks is identification of the environmental emissions of PPCPs. This study established a facile approach for calculation of PPCP emission factors from raw wastewater and wastewater effluent. Using reported concentrations from WWTPs, nine PPCPs, namely carbamazepine, ciprofloxacin, erythromycin, ibuprofen, ketoprofen, ofloxacin, sulfadiazine, sulfamethoxazole, and trimethoprim, were identified as priority contaminants based on environmental significance (i.e., high detection frequency and potential ecological risk) and data availability. Emission factors were calculated for the nine PPCPs in raw wastewater, secondary effluent, and tertiary effluent for low, medium and high emission scenarios according to the concentration distributions of these nine PPCPs. The emission factors were used to estimate the mass of the PPCPs discharged from the nine provinces and two municipalities of the Yangtze River valley. The total mass of the nine PPCPs emitted into the watershed was estimated as 3867 kg, 8808 kg and 21,464 kg for low, medium and high emission scenarios respectively in 2018. Although uncertainty is inevitable in the emission factors, the reported approach provides a viable alternative to top-down and multimedia fugacity estimation strategies that require an abundance of sewershed-, WWTP-, and compound-specific information that is difficult to collect in developing countries.
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  • Article
    Davis CM, DeCicco-Skinner KL, Hienz RD.
    PLoS One. 2015;10(12):e0144556.
    The current report assessed the effects of low-level proton irradiation in inbred adult male Fischer 344 and Lewis rats performing an analog of the human Psychomotor Vigilance Test (PVT), commonly utilized as an object risk assessment tool to quantify fatigue and sustained attention in laboratory, clinical, and operational settings. These strains were used to determine if genetic differences in dopaminergic function would impact radiation-induced deficits in sustained attention. Exposure to head-only proton irradiation (25 or 100 cGy) disrupted rPVT performance in a strain-specific manner, with 25 cGy-exposed Fischer 344 rats displaying the most severe deficits in sustained attention (i.e., decreased accuracy and increased premature responding); Lewis rats did not display behavioral deficits following radiation. Fischer 344 rats displayed greater tyrosine hydroxylase and dopamine transporter levels in the frontal cortex compared to the Lewis rats, even though radiation exposure increased both of these proteins in the Lewis rats only. Tyrosine hydroxylase was decreased in the parietal cortex of both rat strains following radiation exposure, regardless of proton dose. Strain-specific cytokine changes were also found in the frontal cortex, with the Lewis rats displaying increased levels of putative neurotrophic cytokines (e.g., CNTF). These data support the hypothesis that basal dopaminergic function impacts the severity of radiation-induced deficits in sustained attention.
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  • Book
    a compilation of paintings prepared by Frank H. Netter ; editor, James C. Reynolds ; senior associate editor, Peter J. Ward ; associate editors, Suzanne Rose, Missale Solomon, Christopher Steele ; additional illustrations by, Carlos A.G. Machado.
    Summary: "Offering a concise, highly visual approach to the basic science and clinical pathology of the digestive system, this updated volume in The Netter Collection of Medical Illustrations (the CIBA "Green Books") contains unparalleled didactic illustrations reflecting the latest medical knowledge. Revised by Drs. James C. Reynolds, Peter J. Ward, Suzanne Rose, Missale Solomon, and Christopher Steele, Lower Digestive Tract, Part 2 of the Digestive System, Volume 9, integrates core concepts of anatomy, physiology, and other basic sciences with common clinical correlates across health, medical, and surgical disciplines. Classic Netter art, updated and new illustrations, and modern imaging continue to bring medical concepts to life and make this timeless work an essential resource for students, clinicians, and educators"-- publisher's description.

    Contents:
    Overview of lower digestive tract
    Small bowel
    Colon.
    Digital Access ClinicalKey [2025]