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  • Article
    Chen K, Liu X, Wu X, Xu J, Dong F, Zheng Y.
    Chemosphere. 2021 Jan;263:127960.
    Thiacloprid is a neonicotinoid insecticide used to control sucking and chewing insects of fruits and vegetables. Hydrolysis, photolysis of thiacloprid in aqueous solutions, and soil degradation of three typical types of soil in China were studied. UHPLC-QTOF/MS was used to acquire high-resolution mass spectrometry information of thiacloprid's degradation products in water and soil samples, and the UNIFI platform with integrated data processing function was used to find and identify degradation products. The degradation kinetics of thiacloprid was determined. Six transformation products (M271, M287, M269, M295, M279, M267) were found after the data processing workflow in the UNIFI platform by using the raw MSE data. The structure of putative transformation products can be inferred based on the accurate mass of fragment ions and the automated spectral interpretation tools in the UNIFI platform. The structure of M271 was validated to be thiacloprid amide by comparing the ESI-MS2 fragment ions in soil samples and thiacloprid amide standard. The TrendPlot function of UNIFI was used to demonstrate the kinetics of the transformation products. Reduction, hydrolysis, oxidation are the main reactions of thiacloprid in three tested soil in China and buffer solutions. This study provided a reference for the rapid identification of the transformation products of other pesticides in specific environmental conditions.
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  • Article
    Zhang F, Peng G, Xu P, Zhu L, Li C, Wei N, Li D.
    J Hazard Mater. 2022 03 05;425:127960.
    Microplastic (MP) pollution is ubiquitous in the terrestrial and marine environments, even in the air. However, ecological risk assessment studies of microplastics are scarce. In the present study, an ecological risk assessment model was built to evaluate the risks of microplastics in the Yangtze River Estuary and adjacent marine areas. A basic index database of the impacts of MP pollution on the ecosystem was constructed around three types of indices, namely, the pressure, status, and response indices. While the expert scoring method was used to determine the weights of these indices, in view of the complexity of the ecosystem in the Yangtze River Estuary, the fuzzy comprehensive evaluation method was used to evaluate its ecological risk. According to the model, microplastic pollution in the Yangtze River Estuary and adjacent marine areas was within a lower risk state, indicating that its risks for the marine ecosystem were still within a controllable range.
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  • Article
    Shen X, Zhao F, Zhao Z, Yu J, Sun Z.
    Microbiol Res. 2024 Oct 31;290:127960.
    Diabetes mellitus (DM) is a common metabolic disease and one of the diseases with the highest number of complications at present. As the disease progresses, patients will gradually develop diabetes-related cognitive decline, mild cognitive impairment (MCI) or even dementia. The occurrence of diabetes-combined cognitive impairment undoubtedly imposes a heavy burden on patients and their families. Current research suggests that risk factors such as blood glucose levels, insulin resistance, oxidative stress and neuroinflammation have an important role in the development of diabetic cognitive impairment (DCI). With the development of technology and in-depth research, the relationship between the two-way communication between the gut and the brain has been gradually revealed, and more studies have found that the gut microbiota plays an important role in the development of DCI. This review explores the feasibility of probiotics as a potential strategy to assist in the improvement of DCI and its potential mechanisms from the perspective of the factors affecting DCI.
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  • Article
    Coffigniez F, Rychlik M, Mestres C, Striegel L, Bohuon P, Briffaz A.
    Food Chem. 2021 Mar 15;340:127960.
    Folate is a fundamental vitamin for metabolism in plants and humans. A modelling approach has been developed to characterize the reactivity of folates in cowpea seeds during germination at 30 °C, using a water-to-seed ratio of 1:1 (w/w). For this purpose, the concentrations of folic acid, 10-formylfolic acid, 5-methyltetrahydrofolate, 5-formyltetrahydrofolate and tetrahydrofolate were determined in seeds during germination times up to 96 h. Two reaction models were sequentially built and adjusted to experimental data to describe changes in concentration in cowpea seed during two germination phases: before 14 h and after 48 h. Results showed intense enzymatic interconversion of all folate vitamers into 5-methyltetrahydrofolate before 14 h of germination and high enzymatic production of 5-methyltetrahydrofolate, 5-formyltetrahydrofolate and tetrahydrofolate after 48 h of germination. This study suggests that a long germination process could be more beneficial than soaking to increase the production of bioavailable folates within the seed for human consumption.
    Digital Access Access Options
  • Article
    Kong G, Wang K, Zhang X, Li J, Han L, Zhang X.
    Bioresour Technol. 2022 Nov;363:127960.
    Biomass to H2-enriched syngas is a very promising route to produce clean energy. This work proposed a new concept of promoting H2-enriched syngas production and tar elimination through torrefaction/carbonization-enhanced gasification-steam reforming (T/CEGSR) of wheat straw (WS) over its gasification biochar materials (GCMs). WS torrefied at 280 °C (WS-280) subjected to gasification-steam reforming (GSR) over C-control presented the maximum gas yields and H2/CO molar ratio (1.72). By introducing C[10 %O2] for GSR of WS-280, the maximum cumulative gas yield (112.10 mmol/greactants), H2 yield (59.91 mmol/greactants), and syngas yield (94.10 mmol/greactants) were achieved. Furthermore, C[10 %O2] were superior to C-control, C[Ar] and C[CO2] in light of carbon conversion efficiency, cold gas efficiency, and tar yield, reaching 97.45C%, 118.40 %, and 3.36 g/Nm3, respectively. Simply put, this study provides a newly sustainable and promising route by combining biomass torrefaction/carbonization with GSR using gasification biochar for enhancing H2-enriched syngas production while reducing tar formation.
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  • Article
    Tolley K, Hutchinson M, You X, Wang P, Sperling B, Taneja A, Siddiqui MK, Kinter E.
    PLoS One. 2015;10(6):e0127960.
    Subcutaneous pegylated interferon beta-1a (peginterferon beta-1a [PEG-IFN]) 125 μg every two or four weeks has been studied in relapsing-remitting multiple sclerosis (RRMS) patients in the pivotal Phase 3 ADVANCE trial. In the absence of direct comparative evidence, a network meta-analysis (NMA) was conducted to provide an indirect assessment of the relative efficacy, safety, and tolerability of PEG-IFN versus other injectable RRMS therapies. Systematic searches were conducted in MEDLINE, Embase, and the Cochrane Library, and conference proceedings from relevant annual symposia were hand-searched. Included studies were randomized controlled trials evaluating ≥1 first-line treatments including interferon beta-1a 30, 44, and 22 μg, interferon beta-1b, and glatiramer acetate in patients with RRMS. Studies were included based on a pre-specified protocol and extracted by a team of independent reviewers and information scientists, utilizing criteria from NICE and IQWiG. In line with ADVANCE findings, NMA results support that PEG-IFN every 2 weeks significantly reduced annualized relapse rate, and 3- and 6-month confirmed disability progression (CDP) versus placebo. There was numerical trend favoring PEG-IFN every 2 weeks versus other IFNs assessed for annualized relapse rate, and versus all other injectables for 3- and 6-month CDP (6-month CDP was significantly reduced versus IFN beta-1a 30 μg). The safety and tolerability profile of PEG-IFN beta-1a 125 μg every 2 weeks was consistent with that of other evaluated treatments. Study limitations for the NMA include variant definitions of relapse and other systematic differences across trials, assumptions that populations were sufficiently similar, and inability to perform NMA of adverse events. With similar efficacy compared to other RRMS treatments in terms of annualized relapse rate and 3- and 6-month CDP, a promising safety profile, and up to 93% reduction in number of injections (which may improve adherence), PEG-IFN every 2 weeks offers a valuable alternative treatment option for patients with RRMS.
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  • Article
    Zhang X, Yu W, Xu X, Shao X, Li Z.
    Bioorg Med Chem Lett. 2021 07 01;43:127960.
    In the studies on dihydroxy intermediate synthesis, a serendipitous reaction of introducing nitro group from nitromethylene has been observed. Instead of expected dihydroxy compounds, dinitration structures with nitromethylene analogues were prepared under mild conditions by using a metal-free catalyst B(OH)3. In this reaction, the extra nitro group was suggested to be from starting material. Bioassays indicated that compound 3a showed good insecticidal activities against cowpea aphid (Aphis craccivora) and armyworm (Mythimna separata), with LC50 values were 4.9 mg/L and 7.1 mg/L, respectively.
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  • Article
    Bian D, Chen Z, Ouyang Y, Wang S, Wang M, Chen W.
    Int J Biol Macromol. 2024 Jan;254(Pt 3):127960.
    The rapid and effective hemostasis of gastrointestinal bleeding sites remains an urgent clinical challenge. In this study, an ultrafast self-gelling, sprayable, and adhesive carboxymethyl chitosan/poly-γ-glutamic acid/oxidized dextran (CPO) powder was designed for gastric perforation hemostasis and healing. When the CPO powder was sprayed to the gastric perforation site, the CPO powder absorbed water from the blood and concentrate blood cells and clotting factors to achieve the purpose of rapid hemostasis. During the hemostasis, the CPO powder formed a hydrogel in situ through the formation of amide bonds and Schiff base bonds within 15 s, forming a physical barrier to cover the wound surface. Concurrently, the aldehyde group (-CHO) of oxidized dextran formed additional Schiff base bonds with the amino group (-NH2) of the tissue, enabling the CPO powder with wound surface adhesion. Moreover, the CPO powder was shown to have excellent in vitro and in vivo antibacterial properties and it was able to promote the healing of infected wounds in a mouse model. In summary, CPO powder provides a promising idea for the rational design of gastrointestinal hemostatic agents.
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  • Book
    Ignacio E. Tapia, Christopher M. Cielo, Liat Tikotzky.
    Summary: "Ideal for sleep specialists, pediatricians, or family medicine practitioners, Assessment and Treatment of Infant Sleep provides in-depth information about normal aspects of sleep in infancy, as well as both medical and behavioral sleep problem assessment and management. This unique resource offers concise, consolidated guidance when preparing for a clinic or rotation with patients in infancy or when engaging in treatment planning for young children with sleep problems"-- publisher's description.

    Contents:
    Developmental aspects of sleep
    Medical sleep disorders of infancy
    Behavioral sleep disorders in infancy.
    Digital Access ClinicalKey [2024]