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  • Article
    Wang F, Akashi K, Murakami Y, Inoue Y, Furuta T, Yamada H, Ohtomo K, Kiryu S.
    PLoS One. 2014;9(4):e94945.
    Due to their small size, lung tumors in rodents are typically investigated using high-field magnetic resonance (MR) systems (4.7 T or higher) to achieve higher signal-to-noise ratios, although low-field MR systems are less sensitive to susceptibility artifacts caused by air in the lung. We investigated the feasibility of detecting lung tumors in living, freely breathing mice with a 1-T compact permanent magnet MR system. In total, 4 mice were used, and MR images of mouse lungs were acquired using a T1-weighted three-dimensional fast low-angle shot sequence without cardiac or respiratory gating. The delineation and size of lung tumors were assessed and compared with histopathological findings. Submillimeter lesions were demonstrated as hyperintense, relative to the surrounding lung parenchyma, and were delineated clearly. Among the 13 lesions validated in histopathological sections, 11 were detected in MR images; the MR detection rate was thus 84.6%. A strong correlation was obtained in size measurements between MR images and histological sections. Thus, a dedicated low-field MR system can be used to detect lung tumors in living mice noninvasively without gating.
    Digital Access Access Options
  • Book
    Devjani, Shivali; Falade, Leke; Fridland, Stas; Nahar, Ankur; Onyekweli, Tito; Ryu, Brendan; Trippiedi, Andrew; Navarrete-Welton, Allison; Xu, Jason; Xu, Michael.
    Summary: Clinical Capsules: Renal and Genitourinary System is a collection of clinical learning modules covering diseases and disorders of the kidneys and urinary tract created for students to reference during rotations and preparation for taking Shelf and USMLE exams. Originally derived from Thieme’s authoritative German-language medical textbook content and digital learning platform, Via Medici, the modules have been translated and carefully adapted by 4th-year medical students and residents in the U.S. to fit the standards of practice in the U.S. Modules are templated and include Epidemiology, Pathogenesis, Signs and Symptoms, Diagnosis, and Treatment for renal and genitourinary system diseases and disorders commonly tested on Shelf and USMLE exams. The modules are also useful for exam preparation, with concise overviews, learning and exam tips, and high-yield facts, and clinical rotation support, with links to key treatment guidelines and other information for each disease and disorder. Additionally, volumes are organized by organ system and specialty with regularly updated information supplemented by illustrations, diagrams, radiographic images, and tables. -- Publisher

    Contents:
    Contents
    Introduction
    Acute kidney injury
    Chronic kidney disease (CKD)
    Glomerulopathies: Overview
    Glomerulopathies with nephritic syndrome
    Glomerulopathies with nephrotic syndrome
    Urolithiasis
    Polycystic kidney disease
    Urinary incontinence
    Erectile dysfunction
    Benign prostatic hyperplasia
    Prostate cancer
    Bladder cancer
    Renal cell carcinoma
    Testicular cancer
    Urethritis and cystitis
    Chlamydia infections
    Gonorrhea
    Syphilis
    Digital Access Thieme MedOne Education [2024]