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  • Article
    Pravdin SF, Dierckx H, Katsnelson LB, Solovyova O, Markhasin VS, Panfilov AV.
    PLoS One. 2014;9(5):e93617.
    We develop a numerical approach based on our recent analytical model of fiber structure in the left ventricle of the human heart. A special curvilinear coordinate system is proposed to analytically include realistic ventricular shape and myofiber directions. With this anatomical model, electrophysiological simulations can be performed on a rectangular coordinate grid. We apply our method to study the effect of fiber rotation and electrical anisotropy of cardiac tissue (i.e., the ratio of the conductivity coefficients along and across the myocardial fibers) on wave propagation using the ten Tusscher-Panfilov (2006) ionic model for human ventricular cells. We show that fiber rotation increases the speed of cardiac activation and attenuates the effects of anisotropy. Our results show that the fiber rotation in the heart is an important factor underlying cardiac excitation. We also study scroll wave dynamics in our model and show the drift of a scroll wave filament whose velocity depends non-monotonically on the fiber rotation angle; the period of scroll wave rotation decreases with an increase of the fiber rotation angle; an increase in anisotropy may cause the breakup of a scroll wave, similar to the mother rotor mechanism of ventricular fibrillation.
    Digital Access Access Options
  • Article
    Wang H, Yan Z, Zhang Z, Jiang K, Yu J, Yang Y, Yang B, Shu J, Yu Z, Wei Z.
    Environ Sci Pollut Res Int. 2023 Sep;30(41):93617-93628.
    Volatile organic compounds (VOCs) released along with soil disturbance during the remediation of abandoned industrial sites have attracted great attention due to their possible toxicity and odour. However, the real-time emission characteristics of these VOCs and their subsequent effects on health and olfaction are less understood. In this study, the gaseous VOCs released from soil disturbance by excavators and drilling rigs at an abandoned chemical pesticide plant were monitored online with a laboratory-built single photoionization time-of-flight mass spectrometer (SPI-TOFMS). Twelve main VOCs with total mean concentrations ranging from 2350 to 3410 μg m-3 were observed, with dichloromethane (DCM) having a significant contribution. The total concentrations of the remaining 11 VOCs increased substantially during soil disturbance, with the total mean concentrations increasing from 18.65-39.05 to 37.95-297.94 μg m-3 and those of peak concentrations increasing from 28.46-58.97 to 88.38-839.13 μg m-3. This increase in VOC concentrations during soil disturbance leads to an enhanced heath risk for on-site workers. The distinctive difference between the mean and peak concentrations of VOCs indicates the importance of using mean and peak concentrations, respectively, for risk and olfactory evaluation due to the rapid response of the human nose to odours. As a result, the cumulative noncarcinogenic risk at the relatively high pollutant plot was higher than the occupational safety limit, while the total carcinogenic risks at all monitored scenarios exceeded the acceptable limit. Among the VOCs investigated, DCM and trichloroethylene (TCE) were determined to be crucial pollutants for both noncarcinogenic and carcinogenic risks of VOCs. With regard to olfactory effects, organic sulphides, including dimethyl disulphide (DMDS), dimethyl sulphide (DMS), and dimethyl trisulphide (DMTS) were identified as dominant odour contributors (78.28-92.11%) during soil disturbance.
    Digital Access Access Options
  • Book
    Lesley-Ann Noel ; art by Che Lovelace.
    Summary: "Learn how to use design to fight for equity and inclusion, featuring ten strategies for taking creative risks to bring about change-from Stanford University's d.school"-- Provided by publisher.

    Contents:
    1 What's wrong? Building critical awareness
    Know yourself
    Raising critical awareness
    Recognizing oppression
    Listening to and seeing others
    Focusing on equity and justice
    2 What does it feel like? Deepening emotional intelligence
    Anger and joy
    On being intentionally oppositional
    Stronger together
    3 What world do you want to design? Envisioning equitable futures
    Emancipation, liberation, and abolition
    Designing new worlds and futures
    Prototyping and reflecting
    Afterword : I am the change. You are the change.
    Print Access Request
    Location
    Version
    Call Number
    Items
    New Books Shelf (Duck Room)
    2023
    HM831 .N64 2023
    1