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- ArticleRao M, Ma S, Hu S, Lei H, Wu Y, Zhou Y, Xia W, Zhu C.Oncotarget. 2017 Oct 17;8(49):85909-85925.This study aimed to examine the cellular and molecular events that occur in rhesus monkey testes after scrotal hyperthermia. Eight male adult rhesus monkeys were subjected to scrotal hyperthermia at 43°C for 30 min daily for 6 consecutive days. Sperm concentration, reproductive hormones, and testis histology were examined before hyperthermia (day 0), and at 8, 15, 30, 45, 60, 75, and 90 days after the initiation of hyperthermia. iTRAQ-based proteomic analysis was conducted on testicular tissues collected on days 0, 8, and 60 to identify differentially expressed proteins at the early and recovery stages of testicular damage. The sperm concentration was significantly decreased at days 30 and 45 after treatment (p < 0.01) and recovered to baseline at day 60. When compared with day 0, 101 and 24 differentially expressed proteins were identified at days 8 and 60 after heat treatment, respectively. The molecular functions of the differentially expressed proteins at day 8 were mainly nucleic acid binding, unfolded protein binding, nucleotide binding, and nucleoside phosphate binding. Spliceosome was enriched as the most significant pathway at day 8. CIRBP, PSIP1, Sam68, and Decorin were validated and found to be consistent with the proteomic data, indicating the reliability of the proteomic profiles identified in this study. In summary, we suggest that the proteins identified in this study may play important roles in heat-induced spermatogenic impairment. Some of these proteins, such as CIRBP, PSIP1, Sam68, and Decorin, may be early molecular targets responsible for spermatogenesis suppression induced by heat treatment.
- ArticleLi PC, Yang YC, Hwang GY, Kao LS, Lin CY.PLoS One. 2014;9(2):e85909.Levosimendan, a known calcium sensitizer with positive inotropic and vasodilating properties, might also be cardioprotective during ischemia-reperfusion (I/R) insult. Its effects on calcium homeostasis and apoptosis in I/R injury remain unclear. Na(+)/Ca(2+) exchanger (NCX) is a critical mediator of calcium homeostasis in cardiomyocytes, with reverse-mode NCX activity responsible for intracellular calcium overload and apoptosis of cardiomyocytes during I/R. We probed effects and underlying mechanisms of levosimendan on apoptosis and NCX activity in cultured human cardiomyocyte progenitor cells (CPC)-derived cardiomyocytes undergoing anoxia-reoxygenation (A/R), simulating I/R in vivo. Administration of levosimendan decreased apoptosis of CPC-derived cardiomyocytes induced by A/R. The increase in reverse-mode NCX activity after A/R was curtailed by levosimendan, and NCX1 was translocated away from the cell membrane. Concomitantly, endoplasmic reticulum (ER) stress response induced by A/R was attenuated in CPC-derived cardiomycytes treated with NCX-targeted siRNA or levosimendan, with no synergistic effect between treatments. Results indicated levosimendan inhibited reverse-mode NCX activity to protect CPC-derived cardiomyocytes from A/R-induced ER stress and cell death.
- ArticleAhmad N, Muhammad A, Zafar R, Afzal U, Aslam M.Environ Sci Pollut Res Int. 2023 Aug;30(36):85903-85909.The concentrations of potentially toxic metals like lead (Pb), cadmium (Cd), and mercury (Hg) in healthy lactating mothers of Lahore city were estimated during 2020-2021 with the help of a flame atomic absorption spectrometer (FAAS). Seventy samples of breast milk were collected from two different age groups, namely, G-1 (25-30 years) and G-2 (31-40 years). The results showed that Cd contents were below the detection limit of the measuring instrument; however, the Pb and Hg contents were detected with great ease. The mean concentrations of Pb and Hg in the G-1 corresponding to the age between 25 and 30 years were observed to be 1.914 ± 0.493 μg/L and 10.432 ± 3.249 μg/L, respectively. For the G-2 with an age limit between 31 and 40 years, the concentrations of Pb and Hg were estimated to be 2.045 ± 0.502 μg/L and 11.527 ± 3.231 μg/L, respectively. The T-test analysis of concentrations of these toxic metals indicated a significant correlation between the content levels of Pb and Hg (p < 0.05). The observed values of toxic metals were significantly more frequent than those suggested by WHO (World Health Organization). An increase in the concentrations of Pb and Hg is directly associated with the location of the target population. As a result, it is turned out that the majority of the lactating woman with significantly high levels of Pb and Hg belongs to industrial areas of Lahore. To avoid such conditions, residential areas must be at larger distances, in addition, to strictly abiding by the environmental policies of the government.
- BookDaniel H. Pink.Summary: Daniel H. Pink, the #1-bestselling author of Drive and To Sell is Human, unlocks the scientific secrets of good timing to help you flourish at work, at school, and at home. All of us confront a never-ending stream of "when" decisions. When to change jobs. When to schedule a class. When to get serious about a person or a project. Yet we make those decisions haphazardly - based on intuition, hunches, and guesswork. In When: The Scientific Secrets of Perfect Timing, Daniel H. Pink aruges this is exactly the wrong approach. We all know that timing is everything, PInk says. But we assume that timing is an art. In When, he makes clear that timing is really a science. Drawing on a rich trove of research from psychology and biology, neuroscience and economics, Pink reveals in When how best to live, work, and succeed. How can we use the hidden pattern of the day to build the ideal schedule? Why do certain types of daily breaks dramatically improve our children's test scores? How can we turn a mediocre beginning into a fresh start? Why do endings boost motivation and deepen meaning? And how, ultimately, can we make time our ally rather than our enemy? In When, Pink distills cutting-edge research and data and sythesizes them into a fascinating, compelling narrative packed with irresistible stories and practical takeaways. Bursting with big ideas and enduring lessons, it will transform how you think about your past, your present, and your future. -- From dust jacket.
Contents:
Introduction: Captain Turner's decision
Part One. The day. 1. The hidden pattern of everyday life: "Across continents and time zones, as predictable as the ocean tides, was the same daily oscillation - a peak, a trough, and a rebound" ; 2. Afternoons and coffee spoons: The power of breaks, the promise of lunch, and the case for a modern siesta: "A growing body of science makes it clear: Breaks are not a sign of sloth but a sign of strength."
Part Two. Beginnings, endings, and in between. 3. Beginnings: Starting right, starting again, and starting together: "Most of us have harbored a sense that beginnings are significant. Now the science of timing has shown that they're even more powerful than we suspected. Beginnings stay with us far longer than we know; their effects linger to the end." ; 4. Midpoints: What Hanukkah candles and midlife malaise can teach us about motivation: "When we reach a midpoint, sometimes we slump, but other times we jump. A mental siren alerts us that we've squandered half of our time." ; 5. Endings: Marathons, chocolates, and the power of poignancy: "Yet, when endings become salient - whenever we enter an act three of any kind - we sharpen our existential red pencils and scratch out anyone or anything nonessential."
Part Three. Synching and thinking. 6. Synching fast and slow: The secrets of group timing: "Synchronizing makes us feel good - and feeling good helps a group's wheels turn more smoothly. Coordinating with others also makes us do good - and doing good enhances synchronization." ; 7. Thinking in tenses: A few final words: "Most of the world's languages mark verbs with time using tenses - especially past, present, and future - to convey meaning and reveal thinking. Nearly every phrase we utter is tinged with time."