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  • Article
    Merle BM, Maubaret C, Korobelnik JF, Delyfer MN, Rougier MB, Lambert JC, Amouyel P, Malet F, Le Goff M, Dartigues JF, Barberger-Gateau P, Delcourt C.
    PLoS One. 2013;8(11):e79848.
    BACKGROUND: Several genes implicated in high-density lipoprotein (HDL) metabolism have been reported to be associated with age-related macular degeneration (AMD). Furthermore, HDL transport the two carotenoids, lutein and zeaxanthin, which are highly suspected to play a key-role in the protection against AMD. The objective is to confirm the associations of HDL-related loci with AMD and to assess their associations with plasma lutein and zeaxanthin concentrations.
    METHODS: Alienor study is a prospective population-based study on nutrition and age-related eye diseases performed in 963 elderly residents of Bordeaux, France. AMD was graded according to the international classification, from non-mydriatic colour retinal photographs. Plasma lutein and zeaxanthin were determined by normal-phase high-performance liquid chromatography. The following polymorphisms were studied: rs493258 and rs10468017 (LIPC), rs3764261 (CETP), rs12678919 (LPL) and rs1883025 (ABCA1).
    RESULTS: After multivariate adjustment, the TT genotype of the LIPC rs493258 variant was significantly associated with a reduced risk for early and late AMD (OR=0.64, 95%CI: 0.41-0.99; p=0.049 and OR=0.26, 95%CI: 0.08-0.85; p=0.03, respectively), and with higher plasma zeaxanthin concentrations (p=0.03), while plasma lipids were not significantly different according to this SNP. Besides, the LPL variant was associated with early AMD (OR=0.67, 95%CI: 0.45-1.00; p=0.05) and both with plasma lipids and plasma lutein (p=0.047). Associations of LIPC rs10468017, CETP and ABCA1 polymorphisms with AMD did not reach statistical significance.
    CONCLUSION: These findings suggest that LIPC and LPL genes could both modify the risk for AMD and the metabolism of lutein and zeaxanthin.
    Digital Access Access Options
  • Article
    Asakawa H, Ding DQ, Haraguchi T, Hiraoka Y.
    Cold Spring Harb Protoc. 2017 Oct 03;2017(10):pdb.prot079848.
    Fluorescence imaging of living cells provides a unique opportunity to follow dynamic behavior of specific molecules under physiological conditions. In the fission yeast Schizosaccharomyces pombe, expression of a target protein genetically fused with a fluorescent protein such as the jellyfish green fluorescent protein (GFP) is widely used. In addition, fluorescent chemical reagents are also used to stain specific molecules (e.g., Hoechst 33324 to stain DNA). Specimens of S. pombe cells for live cell imaging are prepared by either of two methods: sandwiching the cells between glass coverslips and by mounting the cells on a glass-bottom culture dish. For time-lapse observation, it is necessary to immobilize fission yeast cells on the glass surface of the glass-bottom dish because they are nonadherent and tend to move easily as a result of stage movement, convection flow of culture medium, and the contact and pushing of neighboring cells during cell growth. Either concanavalin A or soybean lectin, which bind to S. pombe cell walls, can be used for immobilization. Considerations for sample preparations and observation conditions are described.
    Digital Access Access Options
  • Book
    Betty Rambur.
    Summary: "This succinct, engaging text for graduate and undergraduate nursing programs distills the complexities of health care finance, economics, and policy into a highly accessible resource that can be applied to any practice setting. It presents economic and financial dynamics in healthcare as a precursor to policy and advocacy in nurses. The second edition adds graduate-level considerations and is updated to reflect our current political and legislative landscape. Real-life illustrations support foundational concepts and interactive quizzes reinforce information. Faculty resources include PowerPoint slides, a test bank, comprehensive review questions, and a sample syllabus"--Publisher's description.

    Contents:
    Section I. The context of health care and health care reform. What is health economics and why is it important to nurses?
    A story of unintended consequences : how economic and policy solutions create new challenges
    The patient protection and Affordable Care Act Of 2010
    Payment reform
    Section II. Health care economics : an overview. How health care markets differ from classic markets
    The role of information in health care markets and decision-making
    Market entry, exit, and antitrust law
    Section III. Ethics and economics in an age of reform. What is ethinomics?
    Additional models to guide ethical decision-making
    Section IV. Pulling it all together : using your knowledge of health finance, economics, and ethics to influence health and health care. Governance and organizational type
    Building skills for board membership
    Applying health economics to influence health care through federal and state policy formation
    Early lessons from the covid pandemic and a look to the future
    Epilogue: Reflections on living and leading in a changing nursing world
    Quiz answers
    Digital Access ProQuest Ebook Central 2022
    Limited to 3 simultaneous users