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  • Article
    Zhang M, Gong W, Zuo B, Chu B, Tang Z, Zhang Y, Yang Y, Zhou D, Weng M, Qin Y, Ma M, Jiang A, Ma F, Quan Z.
    Oncotarget. 2016 Nov 29;7(48):78640-78652.
    Cytokine is a key molecular link between chronic inflammation and gallbladder cancer (GBC) progression. The potential mechanism of cytokine-associated modulation of microRNAs (miRNAs) expression in GBC progression is not fully understood. In this study, we investigated the biological effects and prognostic significance of interleukin-6 (IL-6) -induced miRNAs in the development of GBC. We identify that inflammatory cytokine, IL-6 promotes proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) of GBC both in vitro and in vivo. Among all the changed miRNAs in miRNA profiling, miR-33a expression was significantly decreased in IL-6 treated GBC cell lines, as well as in GBC tissues compared with case-matched normal tissues and cholecystitis tissues. In turn, miR-33a suppresses IL-6-induced tumor metastasis by directly binding Twist which was identified as an EMT marker. High expression of miR-33a suppressed xenograft tumor growth and dissemination in nude mice. The downregulation of miR-33a was closely associated with advanced clinical stage, lymph node metastasis, and poor clinical outcomes in patients with GBC. miR-33a acts as a tumor suppressor miRNA in GBC progression and may be considered for the development of potential therapeutics against GBC.
    Digital Access Access Options
  • Article
    Chang Q, Wei F, Zhang L, Ju X, Zhu L, Huang C, Huang T, Zuo X, Gao C.
    PLoS One. 2013;8(11):e78640.
    Epidemiological studies have shown a relatively strong association between occupational lower back pain (LBP) and long-term exposure to vibration. However, there is limited knowledge of the impact of vibration and sedentariness on bone metabolism of the lumbar vertebra and the mechanism of bone-derived LBP. The aim of this study was to investigate the effects of vibration in forced posture (a seated posture) on biochemical bone metabolism indices, and morphometric and mechanical properties of the lumbar vertebra, and provide a scientific theoretical basis for the mechanism of bone-derived LBP, serum levels of Ca(2+), (HPO4)(2-), tartrate-resistant acid phosphatase (TRAP), bone-specific alkaline phosphatase (BALP), and bone gla protein (BGP),the pathological changes and biomechanics of lumbar vertebra of New Zealand white rabbits were studied. The results demonstrate that both forced posture and vibration can cause pathological changes to the lumbar vertebra, which can result in bone-derived LBP, and vibration combined with a seated posture could cause further damage to bone metabolism. Serological changes can be used as early markers for clinical diagnosis of bone-derived LBP.
    Digital Access Access Options
  • Article
    Cui H, Qi Y, Guo C, Tang N.
    Environ Sci Pollut Res Int. 2023 Jul;30(32):78632-78640.
    Several studies have shown the effects of PM2.5 exposure on respiratory and cardiovascular systems. However, there is no cohort study evidence of adverse effects of PM2.5 exposure on survival in patients with hepatocellular carcinoma (HCC) in China. This study is aimed at evaluating this association. This cohort study included 1440 HCC patients treated at the Third Central Clinical College of Tianjin Medical University from September 2013 to December 2018. We collected patient information, including demographic data, medical history, lifestyle characteristics, and disease characteristics. Based on PM2.5 concentrations measured at monitoring stations, the inverse distance weighted (IDW) method was used to assess the individuals' exposure during their survival period. Survival status was analysed by the Kaplan-Meier method. Restricted cubic splines and Cox proportional hazards models were used to estimate the relationship between PM2.5 and mortality, and potential confounders were adjusted for. The mortality rate of HCC patients exposed to PM2.5 ≥ 58.56 μg/m3 was significantly higher than that of HCC patients living in environments with PM2.5 < 58.56 μg/m3 (79.0% vs 50.7%, P < 0.001). The restricted cubic spline model showed a linear relationship between the PM2.5 concentration and mortality risk (P overall-association < 0.0001 and P nonlinear-association = 0.3568). Cox regression analysis showed that after adjusting for confounding factors, for every 10-μg/m3 increase in atmospheric PM2.5, the risk of death for HCC patients increased by 44% [hazard ratio (HR) = 1.44, 95% confidence interval (CI) 1.34, 1.56; P < 0.001]. Compared with patients exposed to PM2.5 <58.56 μg/m3, those exposed to PM2.5 ≥ 58.56 μg/m3 had a 1.55-fold increased risk of death. Stratified analysis results showed that the effects of PM2.5 on HCC mortality were more significant in patients aged ≥60 years or patients living in central urban areas. We found that exposure to elevated PM2.5 after HCC diagnosis may affect survival, with a higher concentration corresponding to a greater effect.
    Digital Access Access Options
  • Book
    Barbara Klein, Stephen A. Hart, and Jacqueline M. Martinez.
    Summary: "New Understanding of Twin Relationships takes a phenomenological approach to exploring how twin attachment and estrangement are critical to understanding the push and pull of closely entwined personal relationships. Based on the research expertise of each of the authors (all identical twins in their own right), and vignettes from twins across the globe, this book describes the inner workings of the twin-world, showing how the twin-world creates experiences that are often more intense and intricately textured than those in the singleton-world. Chapters debunk myths surrounding twinship and analyze the developmental stages of the twin relationship as well as the effect of being a twin on one's mental health. The editors articulate how attachment, separation anxiety, loneliness, estrangement and the subjective experience of the twin and non-twin "other" impact behavior, thinking, and feeling. Through its careful study of the many psychological challenges that twins face throughout their lifetime, this text will help psychologists, scholars, and clinicians attain a deeper understanding of all interpersonal relationships"-- Provided by publisher

    Contents:
    Introduction / Barbara Klein, Stephan A. Hart, and Jacqueline M. Martinez
    Myth, fantasy, and reality : the challenges twins face sharing their early lives and growing apart / Barbara Klein
    The study of twin experience as twins : a phenomenological approach / Jacqueline M. Martinez
    Communicative intricacies of the twin-world and twin-identities / Jacqueline M. Martinez
    Parenting : the critical determinant of twin-attachment and mental health in twins / Barbara Klein
    Developmental changes in twin relationships / Barbara Klein
    "Alone without the mirror" I : humans, twins, and loneliness / Stephan A. Hart
    "Alone without the mirror" II : twins, separation, and chronic twin-loneliness / Stephan A. Hart
    "In the hall of mirrors" : twins living in the non-twin-world / Stephan A. Hart
    Twin estrangement, significant others, and the relational matrices of the twin-world / Jacqueline M. Martinez
    Can twins be alone in the mirror? : psychotherapy for twins / Barbara Klein
    Conclusion / Barbara Klein, Stephan A. Hart, and Jacqueline M. Martinez.
    Digital Access TandFonline 2020