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  • Article
    Wagner VP, Martins MA, Martins MD, Warner KA, Webber LP, Squarize CH, Nör JE, Castilho RM.
    Oncotarget. 2016 Nov 08;7(45):73032-73044.
    Patients with mucoepidermoid carcinoma (MEC) experience low survival rates and high morbidity following treatment, yet the intrinsic resistance of MEC cells to ionizing radiation (IR) and the mechanisms underlying acquired resistance remain unexplored. Herein, we demonstrated that low doses of IR intrinsically activated NFκB in resistant MEC cell lines. Moreover, resistance was significantly enhanced in IR-sensitive cell lines when NFκB pathway was stimulated. Pharmacological inhibition of the IKK-β/IκBα/NFκB axis, using a single dose of FDA-approved Emetine, led to a striking sensitization of MEC cells to IR and a reduction in cancer stem cells. We achieved a major step towards better understanding the basic mechanisms involved in IR-adaptive resistance in MEC cell lines and how to efficiently overcome this critical problem.
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  • Article
    Matoba T, Kutsukake N, Hasegawa T.
    PLoS One. 2013;8(9):e73044.
    Many social animals have a species-specific repertoire of affiliative behaviours that characterise individualised relationships within a group. To date, however, quantitative studies on intragroup affiliative behaviours in social carnivores have been limited. Here, we investigated the social functions of the two most commonly observed affiliative behaviours in captive African lions (Panthera leo): head rubbing and licking. We conducted behavioural observations on a captive group of lions composed of 7 males and 14 females, and tested hypotheses regarding three social functions: tension reduction, social bonding, and social status expression. Disproportionately frequent male-male and female-to-male head rubbing was observed, while more than 95% of all licking interactions occurred in female-female dyads. In accordance with the social bond hypothesis, and in disagreement with the social status expression hypothesis, both head rubbing and licking interactions were reciprocal. After controlling for spatial association, the dyadic frequency of head rubbing was negatively correlated with age difference while licking was positively correlated with relatedness. Group reunion after daily separation did not affect the frequencies of the affiliative behaviours, which was in disagreement with the predictions from the tension reduction hypothesis. These results support the social bond hypothesis for the functions of head rubbing and licking. Different patterns of affiliative behaviour between the sexes may reflect differences in the relationship quality in each sex or the differential predisposition to licking due to its original function in offspring care.
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  • Book
    American Nursing Informatics Association.
    Summary: Even when we are prepared, downtimes are disruptive, and if an organization is unprepared, they can be chaotic and unsafe. Nursing represents the largest group utilizing the electronic health record (EHR) to care for patients. This guide provides timely and important information, and tools to help organizations prepare for both planned and unplanned downtimes using the SAFER Guides as a model. Nursing is the focus, but the tools can be used as a starting point for other departments as well. Many tools can be used and modified as needed by organizations to meet their needs.
    Digital Access R2Library 2022