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  • Article
    Li N, Ngo CT, Aleynikova O, Beauchemin N, Richard S.
    Oncotarget. 2016 Nov 01;7(44):71651-71659.
    The expression and activities of RNA binding proteins are frequently dysregulated in human cancer. Their roles, however, appears to be complex, with reports indicating both pro-tumorigenic and tumor suppressive functions. Here we show, using two classical mouse cancer models, that the role of KH-type RNA binding protein, Sam68, in tumor development can be influenced by the status of the p53 tumor suppressor. We demonstrate that in mice expressing wild type p53, Sam68-deficiency resulted in a higher incidence and malignancy of carcinogen-induced tumors, suggesting a tumor suppressive role for Sam68. In marked contrast, Sam68-haploinsufficiency significantly delayed the onset of tumors in mice lacking p53 and prolonged their survival, indicating that Sam68 accelerates the development of p53-deficient tumors. These findings provide considerable insight into a previously unknown relationship between Sam68 and the p53 tumor suppressor in tumorigenesis.
    Digital Access Access Options
  • Article
    Lockhart JS, DeVeaux LC.
    PLoS One. 2013;8(8):e71651.
    Recent evidence has implicated single-stranded DNA-binding protein (SSB) expression level as an important factor in microbial radiation resistance. The genome of the extremely radiation resistant bacterium Deinococcus radiodurans contains genes for two SSB homologs: the homodimeric, canonical Ssb, encoded by the gene ssb, and a novel pentameric protein encoded by the gene ddrB. ddrB is highly induced upon exposure to radiation, and deletions result in decreased radiation-resistance, suggesting an integral role of the protein in the extreme resistance exhibited by this organism. Although expression of ssb is also induced after irradiation, Ssb is thought to be involved primarily in replication. In this study, we demonstrate that Ssb in D. radiodurans is essential for cell survival. The lethality of an ssb deletion cannot be complemented by providing ddrB in trans. In addition, the radiation-sensitive phenotype conferred by a ddrB deletion is not alleviated by providing ssb in trans. By altering expression of the ssb gene, we also show that lower levels of transcription are required for optimal growth than are necessary for high radiation resistance. When expression is reduced to that of E. coli, ionizing radiation resistance is similarly reduced. UV resistance is also decreased under low ssb transcript levels where growth is unimpaired. These results indicate that the expression of ssb is a key component of both normal cellular metabolism as well as pathways responsible for the high radiation tolerance of D. radiodurans.
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  • Article
    Roder-DeWan S, Madhavan S, Subramanian S, Nimako K, Lashari T, Bathula AN, Sathurappan R, Kumar S, Chopra M.
    BMJ. 2023 03 13;380:e071651.
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  • Book
    Contents:
    Cover
    Title
    Copyright
    Contents
    Preface
    Pass Guarantee
    Chapter 1: General Examination Information
    Overview
    CCRN Certification Requirements
    About the Examination
    How to Apply
    How to Recertify
    AACN Contact Information
    Resources
    Chapter 2: Cardiovascular System
    Acute Coronary Syndrome
    Overview
    Signs and Symptoms
    Diagnosis
    Labs
    Diagnostic Testing
    Treatment
    Nursing Interventions
    Patient Education
    Aortic Complications
    Overview
    Signs and Symptoms
    Diagnosis
    Labs
    Diagnostic Testing
    Treatment
    Digital Access R2Library [2024]