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  • Article
    Santana MJ, Ahmed S, Fairie P, Zelinsky S, Wilkinson G, McCarron TL, Mork M, Patel J, Wasylak T.
    BMJ Open. 2023 02 02;13(2):e067609.
    OBJECTIVE: To develop a set of patient and family engagement indicators (PFE-Is) for measuring engagement in health system improvement for a Canadian provincial health delivery system through an evidence-based consensus approach.
    DESIGN: This mixed-method, multiphase project included: (1) identification of existing measures of patient and family engagement through a review of the literature and consultations with a diverse provincial council of patients, caregivers, community members and researchers. The Public and Patient Engagement Evaluation Tool (PPEET) was selected; (2) consultations on relevance, acceptability and importance with patient and family advisors, and staff members of Alberta Health Services' Strategic Clinical Networks. This phase included surveys and one-on-one semi-structured interviews aimed to further explore the use of PPEET in this context. Findings from the survey and interviews informed the development of PFE-Is; (3) a Delphi consensus process using a modified RAND/UCLA Appropriateness Method to identify and refine a core set of PFE-Is.
    PARTICIPANTS: The consensus panel consisted of patients, family members, community representatives, clinicians, researchers and healthcare leadership.
    RESULTS: From an initial list of 33 evidence-based PFE-Is identified, the consensus process yielded 18 final indicators. These PFE-Is were grouped into seven themes: communication, comfort to contribute, support needed for engagement, impact and influence of engagement initiative, diversity of perspectives, respectful engagement, and working together indicators.
    CONCLUSIONS: This group of final patient, family and health system leaders informed indicators can be used to measure and evaluate meaningful engagement in health research and system transformation. The use of these metrics can help to improve the quality of patient and family engagement to drive health research and system transformation.
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  • Article
    Bauer JW, Brandl C, Haubenreisser O, Wimmer B, Weber M, Karl T, Klausegger A, Breitenbach M, Hintner H, von der Haar T, Tuite MF, Breitenbach-Koller L.
    PLoS One. 2013;8(7):e67609.
    Evidence is now accumulating that sub-populations of ribosomes - so-called specialized ribosomes - can favour the translation of subsets of mRNAs. Here we use a large collection of diploid yeast strains, each deficient in one or other copy of the set of ribosomal protein (RP) genes, to generate eukaryotic cells carrying distinct populations of altered 'specialized' ribosomes. We show by comparative protein synthesis assays that different heterologous mRNA reporters based on luciferase are preferentially translated by distinct populations of specialized ribosomes. These mRNAs include reporters carrying premature termination codons (PTC) thus allowing us to identify specialized ribosomes that alter the efficiency of translation termination leading to enhanced synthesis of the wild-type protein. This finding suggests that these strains can be used to identify novel therapeutic targets in the ribosome. To explore this further we examined the translation of the mRNA encoding the extracellular matrix protein laminin β3 (LAMB3) since a LAMB3-PTC mutant is implicated in the blistering skin disease Epidermolysis bullosa (EB). This screen identified specialized ribosomes with reduced levels of RP L35B as showing enhanced synthesis of full-length LAMB3 in cells expressing the LAMB3-PTC mutant. Importantly, the RP L35B sub-population of specialized ribosomes leave both translation of a reporter luciferase carrying a different PTC and bulk mRNA translation largely unaltered.
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  • Book
    Mary Bennett Ritter, MD ; introduction by Gesa E. Kirsch ; edited by Gesa Kirsch.
    Summary: "Mary Bennet Ritter was a farmer's daughter who in the 1880s defied all conventions to pursure her passion: to receive medical training and become a physician. Ritter's memoir is a riveting account of her accomplishments and a revealing peek into an earlier era through her keen sense of observation, humor, savvy, and her courage to challenge gender norms. It is filled with adventures--house calls via horse and buggy rides through the dark streets of Berkeley, a spurned lover's suicide, a near drowning at Pacific Grove Beach, one of the first automobile rides across rugged California dirt roads, intercontinental rail travel, and voyages to the Far East. As the story unfolds, readers encounter the movers and shakers of the time--University of California presidents and families of wealth and influence, including the Scrippses, the Hearsts, and the Rockefellers"--Back cover.

    Contents:
    Childhood memories
    Youthful days
    Undercurrents
    An interlude
    Medical student and interne
    First years in Berkeley
    The "ply-wood" of life
    University interests
    Medical practice
    Keeping pace with a biologist
    The quest for a southern site
    A transitional half-decade
    Pioneering in a biological laboratory
    The half decade 1913-1918
    My war work
    The turning of a long lane
    Last years in La Jolla
    The other side of the world
    The South Sea Isles
    Retirement
    Washington days
    Europe again
    Sunset and afterglow.
    Print Access Request
    Location
    Version
    Call Number
    Items
    Books: History - LC Classification (Downstairs)
    2017
    R154.R443 A3 2017
    1