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- ArticleAltemeemy I, Alibrahim NT, Alzajaji QB, Mansour AA.Cureus. 2024 Aug;16(8):e67609.Background Hypertriglyceridemia (HTG) is one of the major modifiable risk factors for the development of several metabolic diseases. Determining the factors associated with HTG is an important step for increasing awareness of the problem and proper planning of health programs for HTG prevention. This study aimed to determine the conditions associated with HTG in adult patients in Basrah, Iraq. Methodology This retrospective study was conducted at Faiha Specialized Diabetes Endocrine and Metabolism Center (FDEMC) in Basra, southern Iraq, in January 2024. The data were retrieved from the center database of 37,133 subjects registered from 2008 to 2023 (16,284, 43.8% males and 20,849, 56.2% females) who attended the FDEMC in Basra due to different reasons. Results The most common causes of HTG were type 2 diabetes mellitus (T2DM) (29,799, 80%), obesity (19,914, 53.63%), and smoking (7,309, 12.68%). The age group of 18-45 years displayed higher triglyceride (TG) levels (281.1 ± 210.1 mg/dL) than other age groups. Furthermore, male patients had higher TG levels than females (288.0 ± 196.3 mg/dL vs. 268.9 ± 165.9 mg/dL). Regarding body mass index, overweight and obese patients had higher mean TG levels (284.4 ± 182.1 mg/dL and 281.7 ± 184.6 mg/dL, respectively). Current and ex-smokers had higher TG levels (305.1 ± 212.2 mg/dL and 283.4 ± 161.3 mg/dL, respectively) than non-smokers (272.5 ± 175.4 mg/dL). Moderate HTG was the most common category encountered in 24,137 patients (65%), followed by mild HTG (12,705, 34.2%). Very few patients had severe (264, 7%) or very severe HTG (27, 0.07%). Male patients had more frequent severe and very severe HTG than females. Conclusions The most common conditions associated with HTG were T2DM, obesity, and smoking. Smoker males were prone to severe and very severe HTG.
- ArticleSantana MJ, Ahmed S, Fairie P, Zelinsky S, Wilkinson G, McCarron TL, Mork M, Patel J, Wasylak T.BMJ Open. 2023 02 02;13(2):e067609.OBJECTIVE: To develop a set of patient and family engagement indicators (PFE-Is) for measuring engagement in health system improvement for a Canadian provincial health delivery system through an evidence-based consensus approach.
DESIGN: This mixed-method, multiphase project included: (1) identification of existing measures of patient and family engagement through a review of the literature and consultations with a diverse provincial council of patients, caregivers, community members and researchers. The Public and Patient Engagement Evaluation Tool (PPEET) was selected; (2) consultations on relevance, acceptability and importance with patient and family advisors, and staff members of Alberta Health Services' Strategic Clinical Networks. This phase included surveys and one-on-one semi-structured interviews aimed to further explore the use of PPEET in this context. Findings from the survey and interviews informed the development of PFE-Is; (3) a Delphi consensus process using a modified RAND/UCLA Appropriateness Method to identify and refine a core set of PFE-Is.
PARTICIPANTS: The consensus panel consisted of patients, family members, community representatives, clinicians, researchers and healthcare leadership.
RESULTS: From an initial list of 33 evidence-based PFE-Is identified, the consensus process yielded 18 final indicators. These PFE-Is were grouped into seven themes: communication, comfort to contribute, support needed for engagement, impact and influence of engagement initiative, diversity of perspectives, respectful engagement, and working together indicators.
CONCLUSIONS: This group of final patient, family and health system leaders informed indicators can be used to measure and evaluate meaningful engagement in health research and system transformation. The use of these metrics can help to improve the quality of patient and family engagement to drive health research and system transformation. - ArticleBauer JW, Brandl C, Haubenreisser O, Wimmer B, Weber M, Karl T, Klausegger A, Breitenbach M, Hintner H, von der Haar T, Tuite MF, Breitenbach-Koller L.PLoS One. 2013;8(7):e67609.Evidence is now accumulating that sub-populations of ribosomes - so-called specialized ribosomes - can favour the translation of subsets of mRNAs. Here we use a large collection of diploid yeast strains, each deficient in one or other copy of the set of ribosomal protein (RP) genes, to generate eukaryotic cells carrying distinct populations of altered 'specialized' ribosomes. We show by comparative protein synthesis assays that different heterologous mRNA reporters based on luciferase are preferentially translated by distinct populations of specialized ribosomes. These mRNAs include reporters carrying premature termination codons (PTC) thus allowing us to identify specialized ribosomes that alter the efficiency of translation termination leading to enhanced synthesis of the wild-type protein. This finding suggests that these strains can be used to identify novel therapeutic targets in the ribosome. To explore this further we examined the translation of the mRNA encoding the extracellular matrix protein laminin β3 (LAMB3) since a LAMB3-PTC mutant is implicated in the blistering skin disease Epidermolysis bullosa (EB). This screen identified specialized ribosomes with reduced levels of RP L35B as showing enhanced synthesis of full-length LAMB3 in cells expressing the LAMB3-PTC mutant. Importantly, the RP L35B sub-population of specialized ribosomes leave both translation of a reporter luciferase carrying a different PTC and bulk mRNA translation largely unaltered.
- ArticleKöbbing L, Kuhn Y, Horstmann B.ACS Appl Mater Interfaces. 2024 Dec 11;16(49):67609-67619.Silicon presents itself as a high-capacity anode material for lithium-ion batteries with a promising future. The high ability for lithiation comes along with massive volume changes and a problematic voltage hysteresis, causing reduced efficiency, detrimental heat generation, and a complicated state-of-charge estimation. During slow cycling, amorphous silicon nanoparticles show a larger voltage hysteresis than after relaxation periods. Interestingly, the voltage relaxes for at least several days, which has not been physically explained so far. We apply a chemo-mechanical continuum model in a core-shell geometry interpreted as a silicon particle covered by the solid-electrolyte interphase to account for the hysteresis phenomena. The silicon core (de)lithiates during every cycle while the covering shell is chemically inactive. The visco-elastoplastic behavior of the shell explains the voltage hysteresis during cycling and after relaxation. We identify a logarithmic voltage relaxation, which fits with the established Garofalo law for viscosity. Our chemo-mechanical model describes the observed voltage hysteresis phenomena and outperforms the empirical Plett model. In addition to our full model, we present a reduced model to allow for easy voltage profile estimations. The presented results support the mechanical explanation of the silicon voltage hysteresis with a core-shell model and encourage further efforts into the investigation of the silicon anode mechanics.
- BookMary Bennett Ritter, MD ; introduction by Gesa E. Kirsch ; edited by Gesa Kirsch.Summary: "Mary Bennet Ritter was a farmer's daughter who in the 1880s defied all conventions to pursure her passion: to receive medical training and become a physician. Ritter's memoir is a riveting account of her accomplishments and a revealing peek into an earlier era through her keen sense of observation, humor, savvy, and her courage to challenge gender norms. It is filled with adventures--house calls via horse and buggy rides through the dark streets of Berkeley, a spurned lover's suicide, a near drowning at Pacific Grove Beach, one of the first automobile rides across rugged California dirt roads, intercontinental rail travel, and voyages to the Far East. As the story unfolds, readers encounter the movers and shakers of the time--University of California presidents and families of wealth and influence, including the Scrippses, the Hearsts, and the Rockefellers"--Back cover.
Contents:
Childhood memories
Youthful days
Undercurrents
An interlude
Medical student and interne
First years in Berkeley
The "ply-wood" of life
University interests
Medical practice
Keeping pace with a biologist
The quest for a southern site
A transitional half-decade
Pioneering in a biological laboratory
The half decade 1913-1918
My war work
The turning of a long lane
Last years in La Jolla
The other side of the world
The South Sea Isles
Retirement
Washington days
Europe again
Sunset and afterglow.