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  • Article
    Li Q, Zhang R, Yan H, Zhao P, Wu L, Wang H, Li T, Cao B.
    Oncotarget. 2017 Sep 15;8(40):67140-67151.
    Human epidermal growth factor receptor 3 (HER3) is closely involved in tumor progression and is an important target of therapy. To evaluate the prognostic significance of HER3 in malignant solid tumors, we searched the PUBMED, EMBASE and CNKI databases for relevant studies written in English or Chinese up to December 2015. Fifteen studies comprising 2964 patients were identified. The HER3+ rate ranged from 9.0-75.1 % in malignant solid tumors: 30.3-75.1 % in breast cancers, 51.1-74.5 % in colorectal cancers, 13.7-59.0 % in gastric cancers, and 54.5-74.4 % in cervical cancers. For patients with a malignant solid tumor, the death risk was higher for those with a HER3+ tumor than for those with a HER3- tumor (HR 1.60, 95% CI: 1.27 - 2.02, P < 0.001). Subgroup analysis revealed this was also the case for patients with digestive or gastric cancer (HR 1.78, P < 0.001; HR 2.18, P < 0.001). By contrast, HER3 had no prognostic significance in colorectal or breast cancer (HR 1.52, P = 0.296; HR 1.23, P = 0.108). HER3+ is thus associated with poor survival in overall and in gastric cancer. The prognostic significance of HER3+ in other tumors is uncertain and deserves further study.
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  • Article
    Li ZQ, Zhang S, Ma Y, Luo JY, Wang CY, Lv LM, Dong SL, Cui JJ.
    PLoS One. 2013;8(6):e67151.
    BACKGROUND: Chrysopa pallens (Rambur) are the most important natural enemies and predators of various agricultural pests. Understanding the sophisticated olfactory system in insect antennae is crucial for studying the physiological bases of olfaction and also could lead to effective applications of C. pallens in integrated pest management. However no transcriptome information is available for Neuroptera, and sequence data for C. pallens are scarce, so obtaining more sequence data is a priority for researchers on this species.
    RESULTS: To facilitate identifying sets of genes involved in olfaction, a normalized transcriptome of C. pallens was sequenced. A total of 104,603 contigs were obtained and assembled into 10,662 clusters and 39,734 singletons; 20,524 were annotated based on BLASTX analyses. A large number of candidate chemosensory genes were identified, including 14 odorant-binding proteins (OBPs), 22 chemosensory proteins (CSPs), 16 ionotropic receptors, 14 odorant receptors, and genes potentially involved in olfactory modulation. To better understand the OBPs, CSPs and cytochrome P450s, phylogenetic trees were constructed. In addition, 10 digital gene expression libraries of different tissues were constructed and gene expression profiles were compared among different tissues in males and females.
    CONCLUSIONS: Our results provide a basis for exploring the mechanisms of chemoreception in C. pallens, as well as other insects. The evolutionary analyses in our study provide new insights into the differentiation and evolution of insect OBPs and CSPs. Our study provided large-scale sequence information for further studies in C. pallens.
    Digital Access Access Options
  • Book
    American Academy of Ambulatory Care Nursing.
    Summary: This newly released publication is an updated scope of practice statement and 17 revised standards for the clinical and administrative professional practice of ambulatory care registered nurses (RNs). The standards promote effective clinical and administrative management of increasingly complex ambulatory care RN roles and responsibilities in a changing health care environment.The 10th edition of the Scope and Standards of Practice for Professional Ambulatory Care Nursing contains some significant revisions from previous versions. In addition to the revised scope of practice, this publication contains 17 standards. The first six standards address the phases of the nursing process; the last 11 standards address professional performance.These changes offer clarification and specificity for the distinct domains of clinical and administrative nursing practice in ambulatory care settings. -- Provided by Publisher.

    Contents:
    Scope and standards revision task force
    Overview of the AAACN standards 10th edition
    Scope of practice for professional ambulatory care nursing
    Standards of Practice for Professional Ambulatory Care Nursing. Standards of professional clinical practice
    Standards of nursing organizational and professional performance.
    Digital Access R2Library [2023]