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  • Article
    Samygina VR, Sokolov AV, Bourenkov G, Petoukhov MV, Pulina MO, Zakharova ET, Vasilyev VB, Bartunik H, Svergun DI.
    PLoS One. 2013;8(7):e67145.
    Copper-containing ferroxidase ceruloplasmin (Cp) forms binary and ternary complexes with cationic proteins lactoferrin (Lf) and myeloperoxidase (Mpo) during inflammation. We present an X-ray crystal structure of a 2Cp-Mpo complex at 4.7 Å resolution. This structure allows one to identify major protein-protein interaction areas and provides an explanation for a competitive inhibition of Mpo by Cp and for the activation of p-phenylenediamine oxidation by Mpo. Small angle X-ray scattering was employed to construct low-resolution models of the Cp-Lf complex and, for the first time, of the ternary 2Cp-2Lf-Mpo complex in solution. The SAXS-based model of Cp-Lf supports the predicted 1:1 stoichiometry of the complex and demonstrates that both lobes of Lf contact domains 1 and 6 of Cp. The 2Cp-2Lf-Mpo SAXS model reveals the absence of interaction between Mpo and Lf in the ternary complex, so Cp can serve as a mediator of protein interactions in complex architecture. Mpo protects antioxidant properties of Cp by isolating its sensitive loop from proteases. The latter is important for incorporation of Fe(3+) into Lf, which activates ferroxidase activity of Cp and precludes oxidation of Cp substrates. Our models provide the structural basis for possible regulatory role of these complexes in preventing iron-induced oxidative damage.
    Digital Access Access Options
  • Book
    Summary: "This Exam Prep Study Guide was designed to be a high-speed review-a last-minute gut check before your exam day. We created this review to supplement to your certification preparation studies. We encourage you to use it in conjunction with other study aids to ensure you are as prepared as possible for the exam. This book follows National Certification Corporation's most recent exam content outlines and uses a succinct, bulleted format to highlight what you need to know. The aim of this book is to help you solidify your retention of information in the month or so leading up to your exam. It is written by certified inpatient obstetric nurses who are familiar with the exam and the content you need to know"-- Provided by publisher.

    Contents:
    General Examination Information
    Antepartum and Intrapartum
    Adaptation to Extrauterine Life
    Neonatal Pharmacology
    Respiratory System
    Cardiovascular System and Circulation
    Gastrointestinal System
    Renal/Genitourinary System
    Nervous System
    Musculoskeletal System
    Integumentary System
    Head, Eyes, Ears, Nose, and Throat
    Endocrine/Metabolic System
    Hematologic System
    Immune System and Infectious Diseases
    Genetic Disorders
    Neonatal Foundations
    Professional Practice
    Practice Exam: Questions
    Practice Exam: Answers
    Pop Quiz Answers.
    Digital Access R2Library [2024]