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  • Article
    Sorrentino C, Miele L, Porta A, Pinto A, Morello S.
    Oncotarget. 2016 Sep 27;7(39):64274-64288.
    The A2B receptor (A2BR) can mediate adenosine-induced tumor proliferation, immunosuppression and angiogenesis. Targeting the A2BR has proved to be therapeutically effective in some murine tumor models, but the mechanisms of these effects are still incompletely understood. Here, we report that pharmacologic inhibition of A2BR with PSB1115, which inhibits tumor growth, decreased the number of fibroblast activation protein (FAP)-expressing cells in tumors in a mouse model of melanoma. This effect was associated with reduced expression of fibroblast growth factor (FGF)-2. Treatment of melanoma-associated fibroblasts with the A2BR agonist Bay60-6583 enhanced CXCL12 and FGF2 expression. This effect was abrogated by PSB1115. The A2AR agonist CGS21680 did not induce CXCL12 or FGF2 expression in tumor associated fibroblasts. Similar results were obtained under hypoxic conditions in skin-derived fibroblasts, which responded to Bay60-6583 in an A2BR-dependent manner, by stimulating pERK1/2. FGF2 produced by Bay60-6583-treated fibroblasts directly enhanced the proliferation of melanoma cells. This effect could be reversed by PSB1115 or an anti-FGF2 antibody. Interestingly, melanoma growth in mice receiving Bay60-6583 was attenuated by inhibition of the CXCL12/CXCR4 pathway with AMD3100. CXCL12 and its receptor CXCR4 are involved in angiogenesis and immune-suppression. Treatment of mice with AMD3100 reduced the number of CD31+ cells induced by Bay60-6583. Conversely, CXCR4 blockade did not affect the accumulation of tumor-infiltrating MDSCs or Tregs. Together, our data reveal an important role for A2BR in stimulating FGF2 and CXCL12 expression in melanoma-associated fibroblasts. These factors contribute to create a tumor-promoting microenvironment. Our findings support the therapeutic potential of PSB1115 for melanoma.
    Digital Access Access Options
  • Article
    Ding ST, Wang CL, Huang YH, Shu CC, Tseng YT, Huang CT, Hsu NC, Lin YF, Tsai HB, Yang MC, Ko WJ.
    PLoS One. 2013;8(5):e64274.
    RATIONALE: Post-discharge care is challenging due to the high rate of adverse events after discharge. However, details regarding post-discharge care requirements remain unclear. Post-discharge medical counseling (PDMC) by telephone service was set-up to investigate its demand and predictors.
    METHODS: This prospective study was conducted from April 2011 to March 2012 in a tertiary referral center in northern Taiwan. Patients discharged for home care were recruited and educated via telephone hotline counseling when needed. The patient's characteristics and call-in details were recorded, and predictors of PDMC use and worsening by red-flag sign were analyzed.
    RESULTS: During the study period, 224 patients were enrolled. The PDMC was used 121 times by 65 patients in an average of 8.6 days after discharge. The red-flag sign was noted in 17 PDMC from 16 patients. Of the PDMC used, 50% (n = 60) were for symptom change and the rest were for post-discharge care problems and issues regarding other administrative services. Predictors of PDMC were underlying malignancy and lower Barthel index (BI). On the other hand, lower BI, higher adjusted Charlson co-morbidity index (CCI), and longer length of hospital stay were associated with PDMC and red-flag sign.
    CONCLUSIONS: Demand for PDMC may be as high as 29% in home care patients within 30 days after discharge. PDMC is needed more by patients with malignancy and lower BI. More focus should also be given to those with lower BI, higher CCI, and longer length of hospital stay, as they more frequently have red flag signs.
    Digital Access Access Options
  • Book
    Maulik S. Joshi, Scott B. Ransom, Elizabeth R. Ransom, David B. Nash, editors.
    Summary: "Every healthcare organization is on its own unique journey, but each one needs a road map to a common destination-quality. Improving the quality of care is an essential strategy for surviving-and thriving-in today's demanding healthcare environment"-- Provided by publisher.

    Contents:
    Overview of healthcare quality / Maulik S. Joshi and Marianthi Hatzigeorgiou
    Quality improvement models and frameworks for excellence / Cathy E. Duquette
    Variation in medical practice and implications for quality / Briget da Graca, David Nicewander, Brett D. Stauffer, and David J. Ballard
    Statistical tools for quality improvement / Davis Balestracci
    Safety science and high reliability organizing / Craig Clapper and Tami Strong
    Health equity and diversity / Deneen Richmond
    Population health / Deneen Richmond
    Quality measurement : measuring what matters / Thomas H. Lee and Deirdre E. Mylod
    Value-based purchasing / Lucy Liu, Rachel Zeldin, Julia Goldner, and Scott B. Ransom
    Health system transformation / Dan Shellenbarger, Bryce Bach, Hector Nelson, and Scott B. Ransom
    Quality and leadership : utilizing measures to create alignment / Michael D. Pugh
    Governance for quality / Kathryn C. Peisert
    The digitization of healthcare / Saad Chaudhry
    Putting It all together : three quality improvement case studies / edited by Kedar Mate and Dan Schummers.
    Digital Access R2Library [2024]