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  • Article
    McGehee MW, Thomas TV, de la Houssaye CJ.
    Cureus. 2024 Jun;16(6):e63426.
    Although pseudomyxoma peritonei (PMP) classically presents with profuse mucinous ascites within the peritoneal cavity, the physical manifestations of this disease exist on a spectrum, with the possibility of milder forms that lack typical findings. The authors report an indolent case of PMP diagnosed incidentally during workup and treatment for chronic cholecystitis in a 43-year-old male. This presentation of PMP was atypical due to a lack of discernible symptoms as well as uncharacteristic intraoperative findings consisting of numerous omental and pelvic adhesions with only sparse mucinous deposits. This case contributes to the growing understanding of PMP by exploring an uncharacteristic presentation of the disease with the hope that it may assist clinicians in diagnosing those cases of PMP that are more indolent and insidious in nature.
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  • Article
    Negash WD, Fetene SM, Shewarega ES, Fentie EA, Asmamaw DB, Teklu RE, Aragaw FM, Belay DG, Alemu TG, Eshetu HB.
    BMJ Open. 2022 07 28;12(7):e063426.
    OBJECTIVE: To determine the magnitude of quality of antenatal care and associated factors among pregnant women in Ethiopia.
    DESIGN: A community-based cross-sectional study.
    SETTING: Ethiopia.
    PARTICIPANTS: A total of 4757 weighted sample of pregnant women from 18 January 2016 to 27 June 2016, were included for this analysis.
    OUTCOME: Quality of antenatal care (ANC).
    METHODS: Our analysis was based on secondary data using the 2016 Ethiopian Demographic and Health Survey. The quality of ANC was measured when all six essential components, such as blood pressure measurements, blood tests, urine tests, nutrition counselling, birth preparation advice during pregnancy and information on potential complications, were provided. Stata V.14 software was used for analysis. A multilevel mixed-effect logistic regression analysis was fitted. Adjusted OR (AOR) with 95% CIs was used to show the strength and direction of the association. Statistical significance was declared at a p value less than 0.05.
    RESULTS: The magnitude of quality of ANC in Ethiopia was 22.48% (95% CI: 21.31% to 23.69%). Educational status; primary (AOR=1.34; 95% CI: 1.06 to 1.68) and secondary (AOR=2.46; 95% CI: 1.76 to 3.45), middle (AOR=1.31; 95% CI: 1.01 to 1.72) and rich (AOR=2.08; 95% CI: 1.59 to 2.72) wealth status, being married (AOR=2.34; 95% CI: 1.08 to 5.10) and four or more ANC (AOR=2.01; 95% CI: 1.67 to 2.40) were statistically significant associated factors of quality ANC in Ethiopia.
    CONCLUSIONS: This study found that nearly only one in five pregnant women received quality ANC during pregnancy. To improve the quality of ANC in Ethiopia, Ministry of Health and health facilities are needed to increase financial support strategies that enable pregnant women from poor households to use health services and enhance pregnant women's understanding of the significance of quality of ANC through health education. Additionally, Community health workers should also be placed on supporting unmarried pregnant women to have quality ANC.
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  • Article
    Mital J, Miller NJ, Dorward DW, Dooley CA, Hackstadt T.
    PLoS One. 2013;8(5):e63426.
    The chlamydial inclusion membrane is extensively modified by the insertion of type III secreted effector proteins. These inclusion membrane proteins (Incs) are exposed to the cytosol and share a common structural feature of a long, bi-lobed hydrophobic domain but little or no primary amino acid sequence similarity. Based upon secondary structural predictions, over 50 putative inclusion membrane proteins have been identified in Chlamydia trachomatis. Only a limited number of biological functions have been defined and these are not shared between chlamydial species. Here we have ectopically expressed several C. trachomatis Incs in HeLa cells and find that they induce the formation of morphologically distinct membranous vesicular compartments. Formation of these vesicles requires the bi-lobed hydrophobic domain as a minimum. No markers for various cellular organelles were observed in association with these vesicles. Lipid probes were incorporated by the Inc-induced vesicles although the lipids incorporated were dependent upon the specific Inc expressed. Co-expression of Inc pairs indicated that some colocalized in the same vesicle, others partially overlapped, and others did not associate at all. Overall, it appears that Incs may have an intrinsic ability to induce membrane formation and that individual Incs can induce membranous structures with unique properties.
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  • Article
    Asadi A, Fakhri Y, Salimi Y, Daglioglu N, Tahmasebifard M, Aghajarinezhad M.
    Environ Sci Pollut Res Int. 2023 May;30(23):63416-63426.
    Wastewater-based epidemiology (WBE), as a rapid tool, is used to measure and monitor illicit drug consumption in the population. This method is also used to bridge biomarkers of exposure, contaminants, and human health. Smoking cigarettes and tobacco use are everyday habits in nowadays community. This systematic review and meta-analysis aimed to calculate nicotine consumption globally. The related studies were retrieved within international databases including Scopus, Google Scholar, and Web of Science, up to February 2021. It included twenty-one articles containing 87 measurements covering 275.3 million people with total wastewater samples of 2250. Results showed that the highest and lowest nicotine consumption rate (mg/1000 inh./day) was in Portugal (5860) and Vietnam (1201), respectively. The global pooled nicotine consumption rate was 2476 mg/1000 inh./day (95% CI (2289-2663). Based on WBE results, the average daily cigarette smoked per smoker is 14 (95% CI: 10-18 cigarettes/inh./day), close to the value of 14.2 reported by the survey and interview studies. Risk assessment of the nicotine consumption rate through WBE was calculated by the margin of exposure (MOE) approach. In total, 82% of nicotine consumption measurements were located in the "risk" level (MOE < 100), and 18% of the MOE values were between 100-1000. The results reveal that nicotine consumption risks need immediate global and local action strategies. Finally, these findings are helpful for healthcare agencies and policy-makers to take action against tobacco use prevalence.
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  • Article
    Peng Y, Yu Q, Yi W.
    ACS Appl Mater Interfaces. 2024 Nov 20;16(46):63419-63426.
    Nitrogen-rich energetic materials are of interest due to their potential use as high-energy-density materials in various applications. However, most compounds with a high nitrogen content show poor thermal stabilities, which may limit their use in certain applications. In pursuit of nitrogen-rich energetic materials, this study presents the synthesis and characterization of two nitrogen rich energetic compounds, namely 3-azido-1-(1H-tetrazol-5-yl)-1H-1,2,4-triazol-5-amine (3, C3H3N11, N%: 79.78) and (E)-1,2-bis(3-azido-1-(1H-tetrazol-5-yl)-1H-1,2,4-triazol-5-yl) diazene (7, C6H2N22, N%: 80.62). Compounds 3 and 7 have high thermal stabilities of 216 and 221 °C, respectively, making them the most thermally stable among metal-free primary explosives. Additionally, they show good energetic performance (vD: 8345 m s-1; P: 25.17 GPa; vD: 8275 m s-1; P: 25.57 GPa), making them potential candidates for metal-free high energy primary explosive. The energetic salts of 3 and 7 were also investigated. Among them, hydrazinium salt 11 displays better energetic performance (vD: 9089 m s-1; P: 30.55 GPa), which was on par with those of cyclotetramethylene tetranitramine (HMX). This research contributes to the exploration of nitrogen-rich energetic materials with potential applications in various fields.
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  • Book
    Angus Clarke ; with contributions from Alex Murray and Julian Sampson.
    Summary: "This eighth edition provides indispensable and up-to-date guidance, helping readers to navigate the profusion of new information in this area and the associated psychosocial and ethical considerations and concerns. Maintaining the trusted framework of earlier editions, the update presents the latest information on the use and interpretation of genetic test results, including new genome-based investigations and their application in the genetic counselling process. This book will help both the student and the practitioner, as genetic and genomic investigations become progressively more relevant to all healthcare professionals with the mainstreaming of genetics across the full range of medical practice"--Publisher's description

    Contents:
    Part 1: General aspects of genetics and genetic counselling. Genetics and genetic counselling: an introduction
    Genetic counselling in Mendelian disorders
    Common disorders and genetic counselling
    Chromosome abnormalities
    Genetic and genomic investigations
    Dysmorphology and genetic syndromes
    Carrier testing
    Predictive genetic testing
    Prenatal diagnosis, antenatal screening and reproductive aspects of medical genetics
    Special issues in genetic counselling
    Clinical genetics services
    Treatments and trials for genetic disease
    Part 2: Genetic counselling: specific organ systems. Neuromuscular disorders
    Central nervous system: paediatric and neurodevelopmental disorders
    Central nervous system: adult-onset and psychiatric disorders
    Disorders of bone and connective tissue
    Oral and craniofacial disorders
    The skin
    The eye
    Deafness
    Cardiac and cardiovascular disorders
    Respiratory disorders
    The gastrointestinal tract
    Renal and urinary tract diseases
    Endocrine and reproductive disorders
    Inborn errors of metabolism
    Disorders of blood and immune function
    Environmental hazards
    Part genetic counselling and testing for cancer
    Cancer as a genetic disorder
    Colorectal cancer syndromes
    Breast and ovarian cancer
    Rare mendelian cancer syndromes and other cancers
    Part genetic counselling in context: the broader picture
    Communication in genetic counselling
    Population aspects of genetic counselling and genetic screening
    Genetics, society and the future
    Glossary
    Appendices. Further reading and information
    Practical genetic counselling: the life story of a book.
    Digital Access TandFonline [2020]
  • Article
    Fed Regist. 1979 Nov 02;44(214):63292-426.
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