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  • Article
    Kawde K, Khan KK, Pisulkar G, Taywade S, Jayasoorya A.
    Cureus. 2024 Jan;16(1):e51619.
    Ankylosing spondylitis (AS) is a chronic inflammatory arthritic disease that primarily affects the axial skeleton, and its association with the secondary development of osteoarthritis (OA) in peripheral joints, particularly the hips, is increasingly recognized. This case report elucidates the diagnostic and therapeutic challenges encountered in a patient with bilateral hip osteoarthritis secondary to AS. The patient's medical history included AS and a failed attempt at core decompression of the left hip joint. The patient was managed with total hip arthroplasty (THA) on the left side due to persistent symptoms. Total hip arthroplasty on the left side involved a meticulous surgical approach, addressing the unique challenges posed by underlying ankylosis. The procedure was conducted uneventfully, with the implantation of a modular femoral head, uncemented femoral stem, and modular shell. Postoperatively, the patient experienced significant pain relief and improved functionality. Successful rehabilitation and management were integral to the overall positive outcome. This case report highlights the complex interplay between AS and hip osteoarthritis, emphasizing the importance of tailored diagnostic and therapeutic strategies. Successful total hip arthroplasty in the setting of AS-related hip osteoarthritis suggests that joint replacement can be effective, but ongoing research is necessary to optimize surgical planning and long-term outcomes in this patient population.
    Digital Access Access Options
  • Article
    Pozdeyev N, Yoo M, Mackie R, Schweppe RE, Tan AC, Haugen BR.
    Oncotarget. 2016 Aug 09;7(32):51619-51625.
    The consistency of in vitro drug sensitivity data is of key importance for cancer pharmacogenomics. Previous attempts to correlate drug sensitivities from the large pharmacogenomics databases, such as the Cancer Cell Line Encyclopedia (CCLE) and the Genomics of Drug Sensitivity in Cancer (GDSC), have produced discordant results. We developed a new drug sensitivity metric, the area under the dose response curve adjusted for the range of tested drug concentrations, which allows integration of heterogeneous drug sensitivity data from the CCLE, the GDSC, and the Cancer Therapeutics Response Portal (CTRP). We show that there is moderate to good agreement of drug sensitivity data for many targeted therapies, particularly kinase inhibitors. The results of this largest cancer cell line drug sensitivity data analysis to date are accessible through the online portal, which serves as a platform for high power pharmacogenomics analysis.
    Digital Access Access Options
  • Article
    Prasad R, Atul, Soni A, Puri SK, Sijwali PS.
    PLoS One. 2012;7(12):e51619.
    Papain-like cysteine proteases of malaria parasites degrade haemoglobin in an acidic food vacuole to provide amino acids for intraerythrocytic parasites. These proteases are potential drug targets because their inhibitors block parasite development, and efforts are underway to develop chemotherapeutic inhibitors of these proteases as the treatments for malaria. Plasmodium knowlesi has recently been shown to be an important human pathogen in parts of Asia. We report expression and characterization of three P. knowlesi papain-like proteases, termed knowpains (KP2-4). Recombinant knowpains were produced using a bacterial expression system, and tested for various biochemical properties. Antibodies against recombinant knowpains were generated and used to determine their cellular localization in parasites. Inhibitory effects of the cysteine protease inhibitor E64 were assessed on P. knowlesi culture to validate drug target potential of knowpains. All three knowpains were present in the food vacuole, active in acidic pH, and capable of degrading haemoglobin at the food vacuolar pH (≈5.5), suggesting roles in haemoglobin degradation. The proteases showed absolute (KP2 and KP3) to moderate (KP4) preference for peptide substrates containing leucine at the P2 position; KP4 preferred arginine at the P2 position. While the three knowpains appear to have redundant roles in haemoglobin degradation, KP4 may also have a role in degradation of erythrocyte cytoskeleton during merozoite egress, as it displayed broad substrate specificity and was primarily localized at the parasite periphery. Importantly, E64 blocked erythrocytic development of P. knowlesi, with enlargement of food vacuoles, indicating inhibition of haemoglobin hydrolysis and supporting the potential for inhibition of knowpains as a strategy for the treatment of malaria. Functional expression and characterization of knowpains should enable simultaneous screening of available cysteine protease inhibitor libraries against knowpains for developing broadly effective compounds active against multiple human malaria parasites.
    Digital Access Access Options
  • Article
    Jordahl D, Armstrong Z, Li Q, Gao R, Liu W, Johnson K, Brown W, Scheiwiller A, Feng L, Ugrinov A, Mao H, Chen B, Quadir M, Li H, Pan Y, Yang Z.
    ACS Appl Mater Interfaces. 2022 Nov 23;14(46):51619-51629.
    Metal-organic frameworks (MOFs) are advanced platforms for enzyme immobilization. Enzymes can be entrapped via either diffusion (into pre-formed MOFs) or co-crystallization. Enzyme co-crystallization with specific metals/ligands in the aqueous phase, also known as biomineralization, minimizes the enzyme loss compared to organic phase co-crystallization, removes the size limitation on enzymes and substrates, and can potentially broaden the application of enzyme@MOF composites. However, not all enzymes are stable/functional in the presence of excess metal ions and/or ligands currently available for co-crystallization. Furthermore, most current biomineralization-based MOFs have limited (acid) pH stability, making it necessary to explore other metal-ligand combinations that can also immobilize enzymes. Here, we report our discovery on the combination of five metal ions and two ligands that can form biocomposites with two model enzymes differing in size and hydrophobicity in the aqueous phase under ambient conditions. Surprisingly, most of the formed composites are single- or multiphase crystals, even though the reaction phase is aqueous, with the rest as amorphous powders. All 20 enzyme@MOF composites showed good to excellent reusability and were stable under weakly acidic pH values. The stability under weakly basic conditions depended upon the selection of enzyme and metal-ligand combinations, yet for both enzymes, 3-4 MOFs offered decent stability under basic conditions. This work initiates the expansion of the current "library" of metal-ligand selection for encapsulating/biomineralizing large enzymes/enzyme clusters, leading to customized encapsulation of enzymes according to enzyme stability, functionality, and optimal pH.
    Digital Access Access Options
  • Book
    Monique Rainford, MD.
    Summary: "A tragedy is unfolding all around us and is receiving well overdue attention. Black women are three times more likely to die from pregnancy than their white peers. But Dr. Monique Rainford is working to better understand these disparities and do something about them. Pregnant While Black is a hopeful exploration of the issues pregnant Black women face in America. Within these pages, Dr. Rainford draws on over twenty years of experience working in obstetrics and gynecology to offer a primer on Black pregnancies and how to better care for them. She shares the successes and testimonies of Black women who have struggled during pregnancy and childbirth, anchoring the stories of these women with carefully researched facts. Despite medical advances over the last twenty years, for Black women, the overwhelming dangers of carrying and delivering children remain and it only seems to be getting worse. In Pregnant While Black, Rainford begins the work of 'repairing the damage of the past' with an examination of the conditions that plague Black pregnancies. This important book carries the hopes and dreams of a generation looking to effect change, here and now."-- Provided by publisher.

    Contents:
    Introduction
    Why Black mothers are dying in America
    Black women and fertility: how is the system failing them?
    A deep dive into miscarriages and why they affect Black women more
    Navigating the healthcare system: the added burden
    Preterm birth story: how the disparity perpetuates
    Multiple gestation: how many Black babies will survive?
    Preeclampsia/hypertensive disorders: too common for Black women
    Stillbirth: the searing pain of loss and why Black women suffer more
    Low birthweight babies: what's in a number?
    Social support for Black pregnant women and the role of the father
    Sickle cell disease and lupus: ignored and undertreated
    Mental health challenges: the silent pandemic
    Covid-19 and the effect on Black pregnant women
    The route of delivery
    The postpartum experience: the care that ends too quickly
    The newborn tax on Black children
    The ray of hope.
    Digital Access ProQuest Ebook Central [2023]
    Limited to 1 simultaneous user
    Print Access Request
    Location
    Version
    Call Number
    Items
    New Books Shelf (Duck Room)
    2023
    RG962.5.B53 R35 2023
    1