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  • Book
    edited by Thomas A. Zdeblick, M.D., AA McBeath Professor and Chairman, ... Show More Department of Orthopedics and Rehabilitation, University of Wisconsin, Madison, Wisconsin, Todd J. Albert, M.D., Richard H. Rothman Professor and Chairman, Department of Orthopaedic Surgery, Professor Of Neurosurgery, Thomas Jefferson University and Hospitals, President, the Rothman Institute, Philadelphia, Pennsylvania.
    Summary: Now in its Third Edition, this volume in the Master Techniques in Orthopaedic Surgery Series combines the step-by-step procedural guidance that readers have come to know with new and updated discussions of specific procedures. The text's how-to format helps readers face the challenges of spinal surgery with confidence. NEW to the Third Edition: Six new chapters address Transpedicular Fixation, Anterior Cervical Arthroplasty, Lateral Lumbar Interbody Fusion, and Lumbar Disc Arthroplasty. Expanded coverage of neurologic issues in spinal surgery broadens the text's scope and assists in presurgical planning and choice of technique.
    Digital Access LWW Health Library 2014
  • Article
    Melo L, Patail H, Gautam G, Braish J, Ozimek D.
    Cureus. 2023 Dec;15(12):e50137.
    Familial Mediterranean fever (FMF) is a hereditary, autosomal recessive auto-inflammatory disorder characterized by recurrent attacks of fever and serositis. While arthritis, pleuritis, peritonitis, and pericarditis are common in FMF, large pericardial effusions with cardiac tamponade as a sequelae of FMF are considered rare.  We report a case of an 83-year-old female with a history of FMF who presented with chest pain. She was found to have acute pericarditis complicated by hemodynamically significant pericardial tamponade that was subsequently treated with an urgent pericardiocentesis followed by colchicine.
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  • Article
    Zeng Q, McCauley LK, Wang CY.
    J Biol Chem. 2002 Dec 20;277(51):50137-42.
    Anoikis, also called suspension-induced apoptosis, plays an important role in tumor development, progression, and metastasis. Recently we found that hepatocyte growth factor (HGF) inhibited anoikis of human head and neck squamous cell carcinoma (HNSCC) cells by activating the extracellular signal-regulated kinase (ERK)-signaling pathway. However, the anti-apoptotic effectors that were regulated by the ERK-signaling pathway were unknown. Here we report that HGF-mediated inhibition of anoikis was dependent on activator protein-1 activity through the activation of the ERK-signaling pathway. Using a combination of microarray analysis and Northern blot analysis, we found that an anti-apoptotic gene cyclooxygenase-2 (cox-2) was induced by HGF in an activator protein-1-dependent fashion. Inhibition of Cox-2 activity partially abolished HGF-mediated cell survival, and overexpression of Cox-2 in HNSCC cells provided resistance against anoikis. Moreover, HNSCC cells stably expressing Cox-2 had aggressive tumor growth in a nude mouse model compared with control cells. Taken together, our results demonstrate that Cox-2 plays an important role in HGF-mediated anoikis resistance. HGF may stimulate the progression and growth of HNSCC in vivo by induction of Cox-2.
    Digital Access Access Options
  • Article
    Bongiorni S, Mancini G, Chillemi G, Pariset L, Valentini A.
    PLoS One. 2012;7(12):e50137.
    Calving in cattle is affected by calf morphology and by dam characteristics. It is described by two different traits: maternal calving ease, which is the ability to generate dams with good physiological predisposition to calving, and direct calving ease, which is the ability to generate calves that are easily born. The aim of this study was to identify regions of cattle genome harboring genes possibly affecting direct calving ease in the Piedmontese cattle breed. A population of 323 bulls scored for direct calving ease (EBV) was analyzed by a medium-density SNP marker panel (54,001 SNPs) to perform a genome-wide scan. The strongest signal was detected on chromosome 6 between 37.8 and 38.7 Mb where 13 SNPs associated to direct calving ease were found. Three genes are located in this region: LAP3, encoding for a leucine aminopeptidase involved in the oxytocin hydrolysis; NCAPG, encoding for a non-SMC condensin I complex, which has been associated in cattle with fetal growth and carcass size; and LCORL, which has been associated to height in humans and cattle. To further confirm the results of the genome-wide scan we genotyped additional SNPs within these genes and analyzed their association with direct calving ease. The results of this additional analysis fully confirmed the findings of the GWAS and particularly indicated LAP3 as the most probable gene involved. Linkage Disequilibrium (LD) analysis showed high correlation between SNPs located within LAP3 and LCORL indicating a possible selection signature due either to increased fitness or breeders' selection for the trait.
    Digital Access Access Options
  • Article
    Garnett A, Yurkiv H, Booth R, Connelly D, Donelle L.
    JMIR Res Protoc. 2023 Oct 27;12:e50137.
    BACKGROUND: The COVID-19 pandemic and resultant restrictions on social gatherings significantly impacted many peoples' sense of social connectedness, defined as an individual's subjective sense of having close relationships with others. Older adults living in long-term care homes (LTCHs) experienced extreme restrictions on social gatherings, which negatively impacted their physical and mental health as well as the health and well-being of their family caregivers. Their experiences highlighted the need to reconceptualize social connectedness. In particular, the pandemic highlighted the need to explore novel ways to attain fulfilling relationships with others in the absence of physical gatherings such as through the use of a hybridized system of web-based and in-person presence.
    OBJECTIVE: Given the potential benefits and challenges of web-based presence technology within LTCHs, the proposed research objectives are to (1) explore experiences regarding the use of web-based presence technology (WPT) in support of social connectedness between older adults in LTCHs and their family members, and (2) identify the contextual factors that must be addressed for successful WPT implementation within LTCHs.
    METHODS: This study will take place in south western Ontario, Canada, and be guided by a qualitative multimethod research design conducted in three stages: (1) qualitive description with in-depth qualitative interviews guided by the Technology Acceptance Model (TAM) and analyzed using content analysis; (2) qualitative description and document analysis methodologies, informed by content and thematic analysis methods; and (3) explicit between-methods triangulation of study findings from stages 1 and 2, interpretation of findings and development of a guiding framework for technology implementation within LTCHs. Using a purposeful, maximum variation sampling approach, stage 1 will involve recruiting approximately 45 participants comprising a range of older adults, family members (30 participants) and staff (15 participants) within several LTCH settings. In stage 2, theoretical sampling will be used to recruit key LTCH stakeholders (directors, administrators, and IT support). In stage 3, the findings from stages 1 and 2 will be triangulated and interpreted to develop a working framework for WPT usage within LTCHs.
    RESULTS: Data collection will begin in fall 2023. The findings emerging from this study will provide insights and understanding about how the factors, barriers, and facilitators to embedding and spreading WPT in LTCHs may benefit or negatively impact older adults in LTCHs, family caregivers, and staff and administrators of LTCHs.
    CONCLUSIONS: The results of this research study will provide a greater understanding of potential approaches that could be used to successfully integrate WPTs in LTCHs. Additionally, benefits as well as challenges for older adults in LTCHs, family caregivers, and staff and administrators of LTCHs will be identified. These findings will help increase knowledge and understanding of how WPT may be used to support social connectedness between older adults in LTCHs and their family members.
    INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): PRR1-10.2196/50137.
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  • Book
    [edited by] Todd J. Albert, Thomas A. Zdeblick.
    Summary: "Part of the highly regarded Master Techniques in Orthopaedic Surgery® series,The Spine, Fourth Edition, is a concise, lavishly illustrated reference covering the most advanced, successful surgical techniques for the spine-all in step-by-step detail. Edited by Drs. Todd J. Albert and Thomas A. Zdeblick, this fully revised edition presents the preferred techniques of surgical masters, illustrated with sequential, surgeon's-eye view intraoperative photographs, as well as superb drawings by noted medical illustrators. New contributing authors and new and rewritten chapters keep you fully up to date with recent changes in the field. Provides the up-to-date guidance you need to face the challenges of spinal surgery with confidence-helping you minimize error, improve outcomes and increase patient safety Features a new chapter on Mini ALIF and Oblique Anterior Lumbar Retroperitoneal Approach, as well as up-to-date coverage of robotics and technological advances Covers indications and contraindications, pitfalls and potential complications, pertinent surgical anatomy, and pearls and tips for improving results Includes abundant full-color photographs of surgical practice and clear illustrations that reveal areas not visible to the surgeon during a procedure Helps you acquire both knowledge and skill as you master the art and science of spine surgery with guidance from leading orthopaedic surgeons Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech. "-- Provided by publisher.
    Digital Access LWW Health Library [2024]