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  • Book
    editors, Richard S. Irwin, Craig M. Lilly, Paul H. Mayo, James M. Rippe.
    Summary: "With a focus on evidence-based, state-of-the-art information throughout, the eighth edition of Irwin and Rippe's Intensive Care Medicine offers authoritative guidance to the wide variety of specialty physicians and non-physicians practicing in the adult intensive care environment. This comprehensive textbook covers both the theoretical and practical aspects of the field, and has been completely updated to provide encyclopedic, interprofessional coverage to support practitioners in every area of this complex field. Features: Approaches intensive care from an interprofessional, collaborative perspective, encompassing anesthesia, surgery, trauma, and neurology, as well as cardiovascular and medical intensive care. Maintains a practical, clinically-oriented approach, with comprehensive sections on procedures, techniques, and ultrasound; minimally invasive monitoring; pharmacology, overdoses, and poisoning; infectious disease; transplantation; critical care consequences of agents of mass destruction; and many more. Features many new chapters, and an entirely new section on Palliative Care and Ethical Issues in the Critical Care Unit. Reflects the rising importance of point-of-care ultrasonography with five hours of expertly narrated video embedded into 23 relevant chapters, clearly depicting the ideal use of this tool for intensivists. Includes a section on ICU Design, Organization, Operation, and Outcome Measures that addresses important changes and advances regarding safety, clinical practice guidelines, decreasing the cost of care, tele-ICU, and more. Provides extensive updates reflecting advances in cardiovascular intensive care, surgical critical care, shock and trauma, and sepsis management. Includes recommendations reflecting randomized controlled clinical trials, summarized, when possible, in quick-reference tables throughout.Your book purchase includes a complimentary download of the enhanced eBook for iOS, Android, PC & Mac. Take advantage of these practical features that will improve your eBook experience: The ability to download the eBook on multiple devices at one time -- providing a seamless reading experience online or offline Powerful search tools and smart navigation cross-links that allow you to search within this book, or across your entire library of VitalSource eBooks Multiple viewing options that enable you to scale images and text to any size without losing page clarity as well as responsive design The ability to highlight text and add notes with one click"-- Provided by publisher.

    Contents:
    1. Procedures, techniques and ultrasonography
    2. Minimally invasive monitoring
    3. Palliative care and ethical issues in the critical care unit
    4. Shock and trauma and sepsis management
    5. Surgical problems in the intensive care unit
    6. Transplantation
    7. Rheumatologic, immunologic, and dermatologic diseases in the intensive care unit
    8. Infectious disease problems in the intensive care unit
    9. Hematologic and oncologic problems in the intensive care unit
    10. Pharmacology, overdoses, and poisonings
    11. Critical care consequences of weapons (or agents) of mass destruction
    12. ICU design, organization, operation, and outcome measures
    13. Endocrine problems in the intensive care unit
    14. Neurologic problems in the intensive care unit
    15. Psychiatric issues in intensive care
    16. Pulmonary problems in the intensive care unit
    17. Cardiovascular problems and coronary care
    18. Renal problems in the intensive care unit
    19. Gastrointestinal disease problems in the intensive care unit
    20. Metabolism/nutrition.
    Digital Access
    Provider
    Version
    Ovid
    2018
    LWW Health Library
    2018
  • Article
    Datta MR, Ghosh MD, AyazAhmed Kharodiya Z.
    Cureus. 2023 Nov;15(11):e49422.
    Introduction Misoprostol (prostaglandin E1 analog) is being used for the induction of labor by vaginal, oral, and sublingual routes. Oral misoprostol is the preferred route for induction of labor, but the use of sublingual misoprostol appears promising due to a faster onset of action. This study was done to compare the efficacy and safety of oral and sublingual misoprostol for induction of labor in term pregnancy. Materials and methods One hundred and sixty patients were randomly allocated to one of the two groups to receive 50 micrograms of oral and sublingual misoprostol four hourly for a maximum of six doses. Primigravida at 37-42 weeks of gestation with singleton pregnancy, cephalic presentation, Bishop score (<5), and reassuring fetal heart rate were included in the study. Misoprostol dose was withheld if the active phase of labor was reached or if the cervix was favorable for amniotomy (Bishop score greater than or equal to eight). The change in the Bishop score with misoprostol was studied along with adverse effects and neonatal outcomes. Results The mean number of 50 mcg misoprostol doses required was significantly less in the sublingual group (2.94±0.97 versus 2.13±0.92; p<0.0001). The rate of change of the mean Bishop score was faster in the sublingual group. After four hours of the first dose, the mean Bishop score changed to 3.52±2.14 versus 4.68±2.34 (p=0.001), and, similarly, after eight hours, it was 10.48±2.59 versus 11.39±2.06, and this difference was statistically significant (p=0.015). The mean induction delivery interval was significantly lower in the sublingual group. The need for labor augmentation, mode of delivery, and adverse effects were similar in both groups. The incidence of meconium-stained liquor and NICU admission was also similar in both groups. Conclusion Sublingmisoprostolstol has a short induction delivery interval and comparable side effects when compared to omisoprostolstol. Sublingmisoprostolstol is recommended for induction of labor at term.
    Digital Access Access Options
  • Article
    Savinova T, Bocharova Y, Mayanskiy N, Chebotar I.
    Microbiol Spectr. 2022 06 29;10(3):e0049422.
    Digital Access Access Options
  • Article
    Zheng H, Ma L, Gui R, Lin X, Ke X, Jian X, Ye C, Chen Q.
    J Virol. 2022 06 22;96(12):e0049422.
    G protein subunit β1 (GNB1), the beta subunit of the G protein family, plays an important role in regulating transmembrane signal transduction. Although a recent study has demonstrated that GNB1 can bind the matrix protein 1 (M1) to facilitate M1 transport to budding sites and promote the release of progeny influenza A virus (IAV), whether the GNB1 protein has other functions in IAV replication requires further study. Here, we found that GNB1 promoted IAV replication, as virus yield decreased in GNB1 knockdown or knockout cells. GNB1 interacted with polymerase subunits PB2, PB1, and PA. Overexpressed GNB1 facilitated PB2 binding to importin α3, α5, and α7 promoting the nuclear import of PB2, enhancing viral RNA synthesis and polymerase activity. Altogether, our results demonstrated that GNB1 positively regulates virus replication by interacting with polymerase subunits and facilitating the nuclear import of PB2, which provide novel insights into the molecular mechanism of IAV. IMPORTANCE Until now, there has been only one article on the role of GNB1 in IAV budding. No study has investigated the role of GNB1 in IAV replication. In this study, our research demonstrated that GNB1 could increase the interaction between PB2 and the importin α isoform and mediate the nuclear import of PB2. Therefore, GNB1 could promote viral replication and transcription. Our results provide a better understanding of the molecular mechanisms of viral replication and provide potential antiviral drug targets.
    Digital Access Access Options
  • Article
    Ben-Zvi AP, Goloubinoff P.
    J Biol Chem. 2002 Dec 20;277(51):49422-7.
    External stresses or mutations may cause labile proteins to lose their distinct native conformations and seek alternatively stable aggregated forms. Molecular chaperones that specifically act on protein aggregates were used here as a tool to address the biochemical nature of stable homo- and hetero-aggregates from non-pathogenic proteins formed by heat-stress. Confirmed by sedimentation and activity measurements, chaperones demonstrated that a single polypeptide chain can form different species of aggregates, depending on the denaturing conditions. Indicative of a cascade reaction, sub-stoichiometric amounts of one fast-aggregating protein strongly accelerated the conversion of another soluble, slow-aggregating protein into insoluble, chaperone-resistant aggregates. Chaperones strongly inhibited seed-induced protein aggregation, suggesting that they can prevent and cure proteinaceous infectious behavior in homo- and hetero-aggregates from common and disease-associated proteins in the cell.
    Digital Access Access Options
  • Article
    Kador PF, Zhang P, Makita J, Zhang Z, Guo C, Randazzo J, Kawada H, Haider N, Blessing K.
    PLoS One. 2012;7(12):e49422.
    OBJECTIVE: Mouse models possessing green fluorescent protein (GFP) and/or human aldose reductase (hAR) in vascular tissues have been established and crossed with naturally diabetic Akita mice to produce new diabetic mouse models.
    RESEARCH DESIGN AND METHODS: Colonies of transgenic C57BL mice expressing GFP (SMAA-GFP), hAR (SMAA-hAR) or both (SMAA-GFP-hAR) in vascular tissues expressing smooth muscle actin were established and crossbred with C57BL/6-Ins2(Akita)/J (AK) mice to produce naturally diabetic offspring AK-SMAA-GFP and AK-SMAA-GFP-hAR. Aldose reductase inhibitor AL1576 (ARI) was administered in chow. Retinal and lenticular sorbitol levels were determined by HPLC. Retinal functions were evaluated by electroretinography (ERGs). Growth factor and signaling changes were determined by Western Blots using commercially available antibodies. Retinal vasculatures were isolated from the neural retina by enzymatic digestion. Flat mounts were stained with PAS-hematoxylin and analyzed.
    RESULTS: Akita transgenics developed DM by 8 weeks of age with blood glucose levels higher in males than females. Sorbitol levels were higher in neural retinas of AK-SMAA-GFP-hAR compared to AK-SMAA-GFP mice. AK-SMAA-GFP-hAR mice also had higher VEGF levels and reduced ERG scotopic b-wave function, both of which were normalized by AL1576. AK-SMAA-GFP-hAR mice showed induction of the retinal growth factors bFGF, IGF-1, and TGFβ, as well as signaling changes in P-Akt, P-SAPK/JNK and P-44/42 MAPK that were also reduced by ARI treatment. Quantitative analysis of flat mounts in 18 week AK-SMAA-GFP-hAR mice revealed increased loss of nuclei/capillary length and a significant increase in the percentage of acellular capillaries present which was not seen in AK-SMAA-GFP-hAR treated with ARI.
    CONCLUSIONS/SIGNIFICANCE: These new mouse models of early onset diabetes may be valuable tools for assessing both the role of hyperglycemia and AR in the development of retinal lesions associated with diabetic retinopathy.
    Digital Access Access Options
  • Article
    Martin RM, Gann ER, Truchon AR, Boyer GL, Wilhelm SW.
    Microbiol Resour Announc. 2022 Sep 15;11(9):e0049422.
    Pseudanabaena spp. are filamentous cyanobacteria widely distributed in temperate lakes. Though infrequent, they can form harmful algal blooms. Here, we present a high-quality metagenome-assembled genome of a Pseudanabaena sp. from a toxic, crimson cyanobacterial bloom in Lake Salubria, NY.
    Digital Access Access Options
  • Article
    Ng CWW, Cai W, So PS, Liao J, Lau SY.
    Environ Sci Pollut Res Int. 2022 Jul;29(32):49422-49428.
    Biochar has a great potential to sustainably improve the performance of bio-engineered slope due to its ability to retain water and to supply nutrients. Existing studies mainly focus on hydrological properties of biochar-amended soil. However, the effects of biochar on shear strength of soil are not well studied. This study aims to assess the shearing behaviour of biochar-amended completely decomposed granite (CDG). Soil specimens were prepared by mixing CDG with two types of biochar at a mass ratio of 5% and compacted at 95% of the maximum dry density. Although the peak shear strength of biochar-amended CDG is reduced by up to 20% because of lower initial dry density of the soil and crushing of biochar particles during shearing, both types of biochar have negligible effects on the ultimate shear strength, which is governed by friction between soil particles. This highlights that the ultimate friction angle can be adopted for designing bio-engineered slopes using biochar-amended soils.
    Digital Access Access Options
  • Article
    Dai W, Gao Z, Li J, Qin S, Wang R, Xu H, Wang X, Gao C, Teng X, Zhang Y, Hao X, Wang Y, Yu W.
    ACS Appl Mater Interfaces. 2021 Oct 20;13(41):49414-49422.
    The Schottky back-contact barrier at the Mo/Cu(In,Ga)Se2 (CIGS) interface is one of the critical issues that restrict the photovoltaic performance of CIGS solar cells. The formation of a MoSe2 intermediate layer can effectively reduce this back-contact barrier leading to efficient hole transport. However, the selenium-free atmosphere is unfavorable for the formation of the desired MoSe2 intermediate layer if the CIGS films are prepared by the commonly used direct sputtering process. In this work, high-efficiency CIGS solar cells with a MoSe2 intermediate layer were fabricated by the direct sputtering process without a selenium atmosphere. This is enabled by an intermediate CIGS layer deposited on the Mo substrate at room temperature before being ramped to a high temperature (600 °C). The room-temperature-deposited amorphous CIGS intermediate layer is Se rich, which reacts with the Mo substrate and forms very thin MoSe2 at the interface during the high-temperature process. The formed MoSe2 decreased the CIGS/Mo barrier height for better hole transport. Consequently, the CIGS solar cell with an 80 nm intermediate layer achieved a power conversion efficiency of up to 15.8%, which is a benchmark efficiency for the direct sputtering process without Se supply. This work provides the industry a new approach for commercialization of directly sputtered CIGS solar cells.
    Digital Access Access Options
  • Book
    editor-in-chief, Craig M. Lilly ; senior editors, Richard S. Irwin, Walter A. Boyle III ; deputy editor for education and self assessment, William F. Kelly
    Summary: "Selected as a Doody's Core Title for 2023! Covering both the theoretical and practical aspects of critical care,Irwin & Rippe's Intensive Care Medicine, Ninth Edition, provides state-of-the-art, evidence-based knowledge for specialty physicians and non-physicians practicing in the adult intensive care environment. Drs. Craig M. Lilly, Walter A. Boyle, and Richard S. Irwin, along with a team of expert contributing authors and education expert, William F. Kelly, offer authoritative, comprehensive guidance from an interprofessional, collaborative, educational, and scholarly perspective, encompassing all adult critical care specialties. Provides easy access to evidence-based critical care practice Offers a practical, clinically oriented approach to intensive care, with detailed descriptions of procedures, incorporating new ultrasound and how-to videos that can easily be accessed in the eBook Key points are identified at the beginning of each chapter and in the margins of the text Key references chosen by the author experts are highlighted at the end of each chapter Available even during network downtime A key educational tool for learning critical care Comprehensive coverage of topics in the field of critical care, including current information provided in 215 chapters authored by well-recognized experts In-depth, comprehensive coverage that allows key skill acquisition Useful resource for board preparation New multiple-choice questions with annotated answers accompany each chapter in the eBook Brings new expertise with senior editor Dr. Walter A. Boyle and online question editor William F. Kelly Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech. "-- Provided by publisher
    Digital Access LWW Health Library [2024]