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  • Book
    [edited by] Holly Hosford-Dunn, Ross J. Roeser, Michael Valente.
    Summary: Provides a comprehensive overview of the most important topics for the successful operation of clinics and private practices. Practical guidelines help the reader master the technical, legal, and financial aspects of daily practice, from the fundamentals of HIPAA compliance, to infection control, to marketing strategies, to integrating quality control and quality improvement using the FOCUS-PDCA model. Leading professionals share their knowledge and expertise, providing the reader with recommendations for documentation, training and supervision, day-to-day accounting, managed care, and more. An essential reference for audiology students and practicing audiologists, as well as for educators, and other health care practitioners participating in service delivery.

    Contents:
    What is practice management? / Holly Hosford-Dunn, Ross J. Roeser, and Michael Valente
    Professional ethics and audiology / Theodore J. Glattke
    Quality : the controlling principle of practice management / Harvey B. Abrams and Theresa Hnath Chisolm
    Human resources management in audiology / David A. Zapala, Kathryn L. Shaughnessy, and Kathryn P. Snyder
    Marketing principles and application / Wayne J. Staab
    Private practice issues / Teresa M. Clark and Darcy Benson
    Health Insurance Portability and Accountability Act (HIPAA) fundamentals / Kadyn Williams, Helena Stern Solodar, and H. Carol Saul
    Outcome measures and evidence-based practice / Theresa Hnath Chisolm and Harvey B. Abrams. Documentation in clinical audiology : an information management perspective / David A. Zapala
    Infection control / A.U. Bankaitis and Robert J. Kemp
    Cerumen management / Ross J. Roeser and Philip L. Wilson
    Supervision / Gyl A. Kasewurm and Kris English
    Writing a business plan / Gyl A. Kasewurm
    Designing an audiology practice / Jane H. Baxter, Deborah W. Clark, and Alan L. Desmond
    Practice accounting / Joy Colle Benn and Robert M. Traynor
    The evolution of reimbursement for audiology / Robert C. Fifer
    Proposing audiology services to group providers / Kathy A. Foltner
    Computer principles and applications / Robert R. De Jonge and J. Mark Goffinet.
    Digital Access Thieme MedOne ComSci ©2008
  • Article
    Xue Y, Toh SY, He P, Lim T, Lim D, Pang CL, Abastado JP, Thierry F.
    Oncotarget. 2015 Oct 27;6(33):34979-91.
    Cervical intraepithelial neoplasia (CIN) is caused by human papillomavirus (HPV) infection and is the precursor to cervical carcinoma. The completion of the HPV productive life cycle depends on the expression of viral proteins which further determines the severity of the cervical neoplasia. Initiation of the viral productive replication requires expression of the E2 viral protein that cooperates with the E1 viral DNA helicase. A decrease in the viral DNA replication ability and increase in the severity of cervical neoplasia is accompanied by simultaneous elevated expression of E6 and E7 oncoproteins. Here we reveal a novel and important role for the HPV16-E2 protein in controlling host cell cycle during malignant transformation. We showed that cells expressing HPV16-E2 in vitro are arrested in prophase alongside activation of a sustained DDR signal. We uncovered evidence that HPV16-E2 protein is present in vivo in cells that express both mitotic and DDR signals specifically in CIN3 lesions, immediate precursors of cancer, suggesting that E2 may be one of the drivers of genomic instability and carcinogenesis in vivo.
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  • Article
    Erdem H, Sarıkcıoğlu L, Boyan N, Savaş K, Yaras N, Oguz O.
    Cureus. 2023 Feb;15(2):e34979.
    Background Vincristine-induced peripheral neuropathy (VIPN) is a distal axonopathy characterized by the loss of distal myelinated axons. This study aimed to assess the potential neuroregenerative roles of vitamin D3 using functional and electron microscopic analyses in a rat model of VIPN. Methodology A total of 40 female Wistar rats were randomly divided into four main groups: Group 1 (control, n = 10), Group 2 (vincristine, n = 10), Group 3 (vincristine + vitamin D3, n = 10), and Group 4 (vincristine + vehicle, n = 10). Vincristine was administered intraperitoneally at a dose of 0.15 mg/kg, for two weeks, to induce peripheral neuropathy. Following successful induction, vitamin D3 (500 IU/kg/day) and vehicle treatments were applied weekly over four weeks. Structural (electron microscopic analysis) and functional analysis (von Frey test, pinch test, and electrophysiological analysis) were performed to assess functional recovery after peripheral nerve impairment. Results Withdrawal responses to mechanical allodynia and pinch tests were significantly higher in the vitamin D3-treated group (P < 0.05). The electrophysiological analysis also supported these results. Electron microscopic evaluation revealed that the remyelinated nerve fibers in the vitamin D3-treated group (Group 3) had thick myelin sheaths and normal axonal morphology. Conclusions Our study demonstrated that vitamin D3 could promote functional and structural recovery in a rat model of VIPN. Further studies should be conducted to elucidate the underlying mechanisms by which vitamin D3 exerts its regenerative effects in VIPN, using alternative administration protocols.
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  • Article
    Gehrig J, Kaulfuß S, Jarry H, Bremmer F, Stettner M, Burfeind P, Thelen P.
    Oncotarget. 2017 May 23;8(21):34971-34979.
    Advanced prostate cancer can develop into castration-resistant prostate cancer (CRPC). This process is mediated either by intratumoral ligand synthesis or by mutations or aberrations of the androgen receptor (AR) or its cofactors. To date, no curative therapy for CRPC is available, as AR-targeted therapies eventually result in the development of resistance. The human prostate cancer cell line VCaP (vertebral cancer of the prostate) overexpresses AR and its splice variants (ARVs) as a mechanism of resistance to androgen-deprivation therapy (ADT) of external and intratumoral origin. In the present study, we demonstrate that stimulating estrogen receptor β activity with the specific agonist 8β-VE2 in VCaP cells in successive stages of ADT induced a time- and dose-dependent decrease in cell survival and an increase in apoptosis. Furthermore, 8β-VE2 treatment reduced the overexpression of the AR as well as ARVs in VCaP cells under maximum ADT. Our results indicate that decreased survival of the androgen-dependent CRPC cells employing apoptosis together with the regulative effect on AR expression could have beneficial effects over current AR-targeting therapies.
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  • Article
    Coppin G, Pool E, Delplanque S, Oud B, Margot C, Sander D, Van Bavel JJ.
    Sci Rep. 2016 10 11;6:34979.
    There is extensive evidence that social identities can shape people's attitudes and behavior, but what about sensory judgments? We examined the possibility that social identity concerns may also shape the judgment of non-social properties-namely, olfactory judgment. In two experiments, we presented Swiss and non-Swiss participants with the odor of chocolate, for which Switzerland is world-famous, and a control odor (popcorn). Swiss participants primed with Swiss identity reported the odor of chocolate (but not popcorn) as more intense than non-Swiss participants (Experiments 1 and 2) and than Swiss participants primed with individual identity or not primed (Experiment 2). The self-reported intensity of chocolate smell tended to increase as identity accessibility increased-but only among Swiss participants (Experiment 1). These results suggest that identity priming can counter-act classic sensory habituation effects, allowing identity-relevant smells to maintain their intensity after repeated presentations. This suggests that social identity dynamically influences sensory judgment. We discuss the potential implications for models of social identity and chemosensory perception.
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  • Article
    Sui H, Yang J, Xiang H, Yan C.
    Medicine (Baltimore). 2023 Sep 15;102(37):e34979.
    We aimed to investigate the role of combined apparent diffusion coefficient (ADC) values and relative cerebral blood flow (rCBF) values in the diagnosis of mild cognitive impairment (MCI) patients. The present prospective research enrolled 156 MCI patients and 58 healthy elderly people who came to our hospital from January 2021 to February 2023. T1W, T2W, diffusion-weighted imaging, and arterial spin labeling sequences were performed on all subjects, and ADC values and rCBF values were measured at the workstation. Clinical and demographic data of all patients were collected while mini-mental state examination (MMSE) and Montreal cognitive assessment (MoCA) scores were used to assess patients' cognitive abilities. The MCI group had significantly lower rCBF values in the left frontal lobe, left occipital lobe, right frontal lobe, and right occipital lobe than the HC group. The ADC values in the left frontal lobe as well as the right frontal lobe were remarkably elevated in the MCI group than in the HC group. MoCA and MMSE scores were positively correlated with rCBF values in the left frontal, right frontal, left occipital, and right occipital lobes and negatively correlated with ADC values in the left and right frontal lobes. Combined ADC values and rCBF values from the left frontal lobe for the diagnosis of MCI had a higher sensitivity and specificity with the AUC was 0.877, sensitivity 81.0%, specificity 82.7%. Additionally, pressure fasting plasma glucose, ADC of the left frontal lobe, right frontal lobe, rCBF of left frontal lobe and rCBF of left frontal lobe were the risk factors of patients with MCI. In summary, our results indicated that the ADC values and rCBF values were changed in MCI group compared to HC group and correlated with MMSE and MoCA scores.
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  • Article
    Wang B, Hu W, Qiao H, Xu Z, Jiang H, Xiao X, Ligthart LP.
    Opt Express. 2023 Oct 09;31(21):34963-34979.
    The paper presents a 170 GHz quasi-optical sub-harmonic mixer with a 3D-printed back-to-back lenses packaging. The quasi-optical mixer is comprised by a pair of antiparallel GaAs Schottky diodes, a patch antenna for receiving local oscillator (LO) pump signal, a symmetric-slit patch antenna for receiving radio frequency (RF) signal, dual 3D-printed lenses and a matching network. The quasi-optical mixer with a pair of antiparallel GaAs Schottky diodes is designed on a multilayer build-up printed circuit board (PCB) utilizing commercially low-cost and high-density interconnect (HDI) technology. The LO and RF antennas are placed on the front and back of the multilayer build-up substrate, respectively, thus significantly simplifying the quasi-optical design. Furthermore, dual 3D-printed lenses placed back-to-back are proposed for LO and RF antennas radiation gain enhancement and mechanical robustness. Additionally, the buried planar reflectors in the substrate maintain effective radiation isolation between the antennas. For facilitating coupling efficiency of signal power into the Schottky diodes and signal isolation between the LO pump signal and RF signal, a compact matching network with low-loss quasi-coaxial via transition structure is integrated in the mixer circuit. The measured single-sideband conversion loss is from 11.3 to 15.4 dB in an operation range of 160 to 180 GHz. The measured radiation patterns agree well with the simulated results.
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  • Article
    Kitahara CM, Platz EA, Ladenson PW, Mondul AM, Menke A, Berrington de González A.
    PLoS One. 2012;7(4):e34979.
    BACKGROUND: We evaluated the association of central versus overall adiposity on levels of thyroid stimulating hormone (TSH), free triiodothyronine (fT(3)), and free thyroxine (fT(4)) among euthyroid subjects taken from a cross-sectional, representative sample of the adult non-institutionalized U.S. population.
    METHODS: The National Health and Nutrition Examination Survey 2007-2008 included 1,623 men and 1,491 women who were 20 years and older, with no history of thyroid or liver disease, kidney failure, diabetes, or thyroid function-altering prescription medication use (based on self-report), and having TSH, fT(3), and fT(4) levels between 0.5-4.49 mIU/L, 2.5-3.9 pg/mL, and 0.6-1.6 ng/dL, respectively. Associations between body mass index (BMI) and waist circumference (measures of overall and central adiposity, respectively) and TSH, fT(3), and fT(4) levels were estimated using multivariable linear regression models stratified by sex and adjusted for age, race, smoking status, and alcohol intake.
    RESULTS: An increase in serum TSH levels was observed for every 1-quartile increase in BMI in euthyroid men (3.8% [95% CI 0.8%, 6.8%]) and euthyroid women (4.0% [95% CI 1.6%, 6.5%]). Similar, albeit slightly weaker, associations were observed with waist circumference. We also found increases in fT(3) levels with every 1-quartile increase in BMI (1.0% in men and 1.3% in women) and waist circumference (1.2% in men and 1.2% in women). No associations were observed with fT(4.)
    CONCLUSIONS: Our results provide support that BMI and waist circumference are positively associated with levels of serum TSH and f T(3) but not fT(4) among euthyroid adults. Longitudinal studies are needed to define the temporality of these associations and their potential health implications.
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  • Article
    Vilanculo CB, José da Silva M.
    RSC Adv. 2021 Oct 25;11(55):34979-34987.
    The activity of the sodium salts of vanadium-doped phosphomolybdic acid was assessed in the oxidative esterification reaction of benzaldehyde with hydrogen peroxide in alkyl alcohol solutions. The effect of main reaction parameters, such as temperature, catalyst load, vanadium doping level, and reactant stoichiometry, on the conversion and reaction selectivity was investigated. Among the tested heteropoly salts, Na4PMo11VO40 was the most active and selective catalyst, achieving almost complete conversion of benzaldehyde and high ester selectivity regardless of the alcohol investigated. The efficiency of the catalyst was correlated with its vanadium content. The size of the carbon chain of alcohol and the steric hindrance on the hydroxyl group played a key role in the reaction selectivity. While methyl and ethyl alcohols selectively provided the ester as the main product (ca. 90-95%) and benzoic acid as a subproduct, the other alcohols also afforded acetal, a condensation product, and benzaldehyde peroxide, an oxidation reaction intermediate, as secondary products. The use of an inexpensive, environmentally benign, and atom-efficient oxidant, mild conditions, and short reaction times were the positive aspects of this one-pot process.
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  • Article
    Fed Regist. 1983 Aug 02;48(149):34979-85.
    These proposed regulations would modify current Medicare rules concerning the option that allows Medicare providers to elect to receive payment directly from HCFA, rather than through an intermediary, for covered services furnished to beneficiaries. The regulations would also give HCFA the authority to make other arrangements to service Health Maintenance Organizations (HMOs) that are presently dealing directly with HCFA. The regulations would clarify that HCFA may contract with any organization for the purpose of making payments to providers and HMOs.
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  • Article
    Valley CC, Cembran A, Perlmutter JD, Lewis AK, Labello NP, Gao J, Sachs JN.
    J Biol Chem. 2012 Oct 12;287(42):34979-34991.
    Of the 20 amino acids, the precise function of methionine (Met) remains among the least well understood. To establish a determining characteristic of methionine that fundamentally differentiates it from purely hydrophobic residues, we have used in vitro cellular experiments, molecular simulations, quantum calculations, and a bioinformatics screen of the Protein Data Bank. We show that approximately one-third of all known protein structures contain an energetically stabilizing Met-aromatic motif and, remarkably, that greater than 10,000 structures contain this motif more than 10 times. Critically, we show that as compared with a purely hydrophobic interaction, the Met-aromatic motif yields an additional stabilization of 1-1.5 kcal/mol. To highlight its importance and to dissect the energetic underpinnings of this motif, we have studied two clinically relevant TNF ligand-receptor complexes, namely TRAIL-DR5 and LTα-TNFR1. In both cases, we show that the motif is necessary for high affinity ligand binding as well as function. Additionally, we highlight previously overlooked instances of the motif in several disease-related Met mutations. Our results strongly suggest that the Met-aromatic motif should be exploited in the rational design of therapeutics targeting a range of proteins.
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  • Article
    Khan ZH, Gao M, Qiu W, Song Z.
    Environ Sci Pollut Res Int. 2021 Jul;28(26):34979-34989.
    The purpose of this study was to develop a MoS2-impregnated biochar (MoS2@BC) via hydrothermal reaction for adsorption of cadmium (Cd) from an aqueous solution. The prepared adsorbents were characterized, and their abilities to remove Cd(II) were evaluated. The Langmuir and pseudo-second-order models better described the removal of Cd(II) by MoS2@BC. The prepared MoS2@BC exhibited excellent monolayer adsorption capacity. The S-containing functional groups on MoS2@BC enhanced the adsorption of Cd(II). Multiple Cd(II) sorption mechanisms were identified; including Cd(II)-π interactions, ion exchange, electrostatic interaction, and complexation. The dominant mechanism involved Cd-O (38.3%) bonds and Cd-S complexation (61.7%) on MoS2@BC. The as-prepared MoS2@BC is both economical and efficient, making it an excellent material for environmental Cd(II) remediation.
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  • Article
    Chen S, Yang X, Tong X, Zhang F, Zou H, Qiao Y, Dong M, Wang J, Fan W.
    ACS Appl Mater Interfaces. 2020 Aug 05;12(31):34971-34979.
    The synergistic effect among different components and the structural and morphological control of catalytic nanomaterials have attracted considerable research interest in the field of electrocatalysis, as using a rational design of the catalytic nanomaterials with the desired structure, morphology, and chemical compositions is an effective strategy for enhancing catalytic performance. Here, by changing the Ni/Co atomic ratio of raw materials, a series of samples with a three-dimensional (3D) hollow porous ternary multicomponent heterostructure has been successfully synthesized via a facile template-free solvothermal approach and subsequently annealing and phosphating treatments, and its formation mechanism is also investigated. By virtue of compositional and structural advantages, the optimized Ni1Co2Px (NiCoP/CoP/CoP2) nanoparticles show very high mass activity (436.9 mA mg-1) and area-specific activity (155 mA cm-2), as well as remarkable durability toward the methanol electrooxidation reaction (MOR) in alkaline solution. This catalytic activity is better than those of most of reported Ni/Co-based nonprecious metal catalysts. Particularly, a multicomponent synergistic effect on the MOR was observed. The present study not only provides a simple method for the fabrication of 3D hollow porous multicomponent composite nanomaterials, but also gives insights into the synergistic effect among the porous structure, chemical compositions, and catalytic activity of nanomaterials in the electrocatalytic oxidation of methanol.
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  • Article
    Ge P, Cao X, Hou H, Li S, Ji X.
    ACS Appl Mater Interfaces. 2017 Oct 11;9(40):34979-34989.
    One-dimensional Sb2Se3/C rods are prepared through self-assembly by inducing anisotropy, and their corresponding sodium storage behaviors are evaluated, presenting excellent electrochemical performances with superior cycling stability and rate capability. Sb2Se3 delivers a high initial charge capacity of 657.6 mA h g-1 at a current density of 0.2 A g-1 between 2.5 and 0.01 V. After 100 cycles, the reversible capacity of Sb2Se3/C is still retained at 485.2 mA h g-1. Even at a high rate current density of 2.0 A g-1, the charge capacity is still retained at 311.5 mA h g-1. Through the analysis of cyclic voltammetry and in situ electrochemical impedance spectroscopy, the in-depth understanding of high rate performances is explored effectively. Briefly, the sodium storage performance of Sb2Se3/C is observably enhanced, benefiting from the 1D structure and the introduction of a carbon layer with robust structure stability and conductivity.
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  • Book
    [edited by] Brian J. Taylor, AuD, Director of Clinical Audiology, Fuel Medical Group, LLC, Camas, Washington ; Adjunct Assistant Professor of Audiology, A.T. Still University, Arizona School of Health Sciences, Mesa, Arizona.
    Summary: Audiology Practice Management, Third Edition by Brian Taylor, provides new and established audiologists with everything they need to know about running a practice in the 21st century. This new edition offers expert approaches to starting and maintaining a practice in audiology - from technical, legal, and financial daily operations - to new issues like HIPAA compliance, social media considerations, and marketing strategies in the digital age. Readers will benefit from the collective knowledge and expertise of audiologists and assorted industry experts who share pearls, controversies, and tips on a wide range of topics, including areas of practice not commonly seen in textbooks. Six new chapters cover key topics including basic management principles, clinical education, pricing strategies, entrepreneurial skills, changes in healthcare documentation, and valuation and exit strategy.
    Digital Access Thieme MedOne ComSci [2019]
  • Article
    Fed Regist. 1986 Oct 01;51(190):34975-9.
    This rule revises the Medicare regulations to change the date for updating the reasonable charge levels applicable to physician and other medical services under the Medicare Supplementary Medical Insurance Program (Part B). we also are adding a provision to explain that the annual economic index that would have been used to determine the amount of any increase in physician prevailing charges from July 1, 1984 through September 30, 1985, and that, through the usual manner, would be used to increase the prevailing charges in subsequent years, is permanently relinquished. In addition, we are adding a provision to reflect the difference between prevailing charges for participating and nonparticipating physicians. These changes implement certain provisions of section 2306(a) of the Deficit Reduction Act of 1984 (DRA) (Pub. L. 98-369) and sections 9301 (b) and (d) of the Consolidated Omnibus Budget Reconciliation Act of 1985 (COBRA) (Pub. L. 99-272), and make other conforming changes.
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