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- ArticleLiu C, Wang D, Wang QH.Opt Express. 2019 Jun 24;27(13):18210-18221.In this paper, a holographic display system with adjustable viewing angle is proposed. The system consists of a collimated beam, a spatial light modulator (SLM), a multi-focus optofluidic (MFO) lens and an aperture. The MFO lens with high focal power is produced and it consists of two substrates, one multilayer substrate and two chambers. When the liquids are pulled in/out from the channels, the curvature of the liquid-liquid interface changes due to the surface tension and adsorption between the liquids and the multilayer substrate. The relationship between the parameters of the MFO lens and the holographic display viewing angle is revealed for the first time. Based on the theoretical analysis, the mechanisms of the high focal power and mechanical stability of the proposed MFO lens are also clarified. The experiments show that the focal power of the proposed MFO lens can be varied from -20 D (m-1) to 4 D (m-1), respectively. By using the MFO lens, the viewing angle of the holographic display system can be adjusted without moving any components mechanically. Meanwhile the setup of the system is greatly simplified. The experimental results verify the feasibility of the system, and it is expected to bring new ideas to the holographic display with large viewing angle.
- ArticleNie JL, Li Q, Yin HT, Yang JH, Li M, Li Q, Fan XH, Zhao QQ, Wen ZP.J Cell Mol Med. 2024 Apr;28(7):e18221.Gliomas are the most common tumours in the central nervous system. In the present study, we aimed to find a promising anti-glioma compound and investigate the underlying molecular mechanism. Glioma cells were subjected to the 50 candidate compounds at a final concentration of 10 μM for 72 h, and CCK-8 was used to evaluate their cytotoxicity. NPS-2143, an antagonist of calcium-sensing receptor (CASR), was selected for further study due to its potent cytotoxicity to glioma cells. Our results showed that NPS-2143 could inhibit the proliferation of glioma cells and induce G1 phase cell cycle arrest. Meanwhile, NPS-2143 could induce glioma cell apoptosis by increasing the caspase-3/6/9 activity. NPS-2143 impaired the immigration and invasion ability of glioma cells by regulating the epithelial-mesenchymal transition process. Mechanically, NPS-2143 could inhibit autophagy by mediating the AKT-mTOR pathway. Bioinformatic analysis showed that the prognosis of glioma patients with low expression of CASR mRNA was better than those with high expression of CASR mRNA. Gene set enrichment analysis showed that CASR was associated with cell adhesion molecules and lysosomes in glioma. The nude mice xenograft model showed NPS-2143 could suppress glioma growth in vivo. In conclusion, NPS-2143 can suppress the glioma progression by inhibiting autophagy.
- ArticleZhang Y, Dong H, Zhang X, Tang B, Tian C, Xu C, Zhou W.Opt Express. 2018 Jul 09;26(14):18214-18221.We report experimental studies on the Fabry-Perot (F-P) type polariton modes and their dynamics using a modified Young's double-slit interference technique. The technique was based on the angle-resolved micro-photoluminescence spectroscopy and optimized for nanostructure measurements. Using this technique, we directly revealed the parity of the F-P type polariton modes from the angle-dependent interference spectra. Moreover, clear features of mode competition were observed from the power dependence of the interference patterns. The observed competition behaviors can be well simulated by a five-level rate equation model.
- ArticleKarimi M, Abdolrahimi S, Pazuki G.RSC Adv. 2019 Jun 10;9(32):18217-18221.Here, we report the implementation of α-amylase conjugated silica microparticles for improvement of α-amylase partitioning in a PEG-organic salt-based aqueous two phase system. A direct reduction method was employed for the synthesis of silica microparticles with simultaneous introduction of α-amylase. In this context, we synthesized three different silica α-amylase conjugated microparticles with variation of tetraethyl orthosilicate concentration, and thus the effect of final particle size and enzyme loading on partitioning was also studied. The partition coefficient ratio of α-amylase to Si:α-amylase of 2.186 : 21.701 validated an almost tenfold increase in separation. The microscopic structure of the system was thoroughly investigated in order to understand the extraction mechanism and any possible denaturation. Improved partition coefficients can be interpreted by the formation of α-amylase-silica-PEG carriers. Furthermore, circular dichroism (CD) spectra validated partial unfolding of the enzyme.
- ArticleRzymski P, Klimaszyk P, Marszelewski W, Borowiak D, Mleczek M, Nowiński K, Pius B, Niedzielski P, Poniedziałek B.Environ Sci Pollut Res Int. 2018 06;25(18):18221.The authors would like to correct the error in the "Abstract" section of original publication. The correct sentence should read "The sampled waters were highly acidic (pH 2.1-4.9) and had high electrical conductivity (2.80-15.61 mS cm-1).
- ArticleCui Y, Cheng H, Tian H, Li C, Tang Y, Mao AJ, Kuang XY.Phys Chem Chem Phys. 2021 Sep 07;23(33):18221-18226.In general, hydrostatic pressure can suppress electrical polarization, instead of creating and/or enhancing polarization like strain engineering. Here, a combination of first-principles calculations and CALYPSO crystal structures prediction is used to point out that hydrostatic pressure applied on antiperovskite MgCNi3 can stabilize polarization with metallicity, and thus a polar metal can exist under high pressure. Strikingly, the metallic polar phase of MgCNi3 exhibits an original linear-cubic coupling between polar and nonpolar modes, resulting in an asymmetrical double-well when the polarization is switched. Moreover, another novel phase of MgCNi3 under high pressure possesses an enhanced hardness stemming from a robust s-s electrons interaction of an unexpected C-C bond, rather than typical sp3 orbital hybridization. These discoveries open new routes to design superhard materials and polar metals.
- ArticleMarcotte S, Castilla C, Morin C, Merlet-Machour N, Carrasco-Cabrera L, Medaerts F, Lavanant H, Afonso C.Environ Sci Pollut Res Int. 2020 May;27(15):18221-18231.Pellet stoves arouse a real interest from consumers because they are perceived as a renewable and carbon neutral energy. However, wood combustion can contribute significantly to air pollution, in particular through the emission of particulate matter (PM). In this article, five brands of wood pellets were burnt under optimal combustion conditions and trace element and inorganic salt emission factors (EFs) in PM were determined. Results show that a significant proportion of metals such as lead, zinc, cadmium, and copper initially present in pellets were emitted into the air during combustion with 20 ± 6%, 31 ± 12%, and 19 ± 6% of the initial content respectively for Zn, Pb, and Cd. The median emission factors for Pb, Cu, Cd, As, Zn, and Ni were respectively 188, 86, 9.3, 8.7, 2177, and 3.5 μg kg-1. The inorganic fraction of the PM emissions was dominated by K+, SO42-, and Cl- with respective EFs of 33, 28.7, and 11.2 mg kg-1. Even taking into account a consumption of 40.1 million tons by 2030 in the EU, the resulting pollution in terms of heavy metal emissions remains minimal in comparison with global emissions in the EU.
- ArticleReiersølmoen AC, Csókás D, Pápai I, Fiksdahl A, Erdélyi M.J Am Chem Soc. 2019 11 13;141(45):18221-18229.Gold-mediated homogeneous catalysis is a powerful tool for construction of valuable molecules and has lately received growing attention. Whereas Au(I)-catalyzed processes have become well established, those mediated by Au(III) have so far barely been explored, and their mechanistic understanding remains basic. Herein, we disclose the combined NMR spectroscopic, single-crystal X-ray crystallographic, and computational (DFT) investigation of the Au(III)-mediated alkoxycyclization of a 1,6-enyne in the presence of a bidentate pyridine-oxazoline ligand. The roles of the counterion, the solvent, and the type of Au(III) complex have been assessed. Au(III) is demonstrated to be the active catalyst in alkoxycyclization. Alkyne coordination to Au(III) involves decoordination of the pyridine nitrogen and is the rate-limiting step.
- ArticleYang YF, Yu P, Houk KN.J Am Chem Soc. 2017 12 20;139(50):18213-18221.The mechanisms of Diels-Alder reactions between 1,2,3-triazines and enamines have been explored with density functional theory computations. The focus of this work is on the origins of the different reactivities and mechanisms induced by substituents and by hexafluoroisopropanol (HFIP) solvent. These inverse electron-demand Diels-Alder reactions of triazines have wide applications in bioorthogonal chemistry and natural product synthesis. Both concerted and stepwise cycloadditions are predicted, depending on the nature of substituents and solvents. The nature of zwitterionic intermediates and the mechanism by which HFIP accelerates cycloadditions with enamines are characterized. Our results show the delicate nature of the concerted versus stepwise mechanism of inverse electron-demand Diels-Alder reactions of 1,2,3-triazines, and that these mechanisms can be altered by electron-withdrawing substituents and hydrogen-bonding solvents.
- ArticleZhang L, Li B, Li R, Wang Y, Ye S, Zhang P, Wu B.J Am Chem Soc. 2023 Aug 23;145(33):18221-18226.Homochiral metal-organic macrocyclic complexes are of great significance owing to their chirality and well-defined internal cavities that potentially have the ability to mimic complicated biological processes. Here we report a novel metal/anion-coordination co-driven strategy for the formation of nanoscale supramolecular metallocycles with unique topology, large size, and desired chirality. The enantiomeric Janus-type metallocyclic strips are assembled based on the synergistic coordination of sulfate anions and CoII ions to a bifunctional achiral ligand combining the o-phenylene-(bis)urea anion-chelating and 8-hydroxyquinoline metal-coordinating sites. The inherent chirality arises from two types of helical chiralities (triply twisted Möbius ring and circular helicate), which is observed for the first time for metal-organic complex systems. Notably, spontaneous chiral resolution by conglomerate crystallization into a pair of enantiomers (P- or M-Co9) is realized, which is attributed to the multiple weak intermolecular interactions facilitating the hierarchically helical superstructure.
- ArticleWang HS, Yang FJ, Long QQ, Huang ZY, Chen W, Pan ZQ, Song Y.Dalton Trans. 2016 Nov 15;45(45):18221-18228.We report the syntheses, crystal structures, and magnetic properties of two 3d-4f heterometallic compounds; namely, [Mn8Ln2O2(OH)2{(py)2CO2}4(teaH)4(CH3COO)6]·6CH3CN·2H2O (LnIII = Dy (1), Tb (2); (py)2CO2H2 = the gem-diol form of di-2-pyridyl ketone, teaH3 = triethanolamine). Both compounds were prepared by the reaction of Mn(OAc)2·4H2O, Ln(NO3)3·5H2O (Ln = Dy and Tb) with the ligands di-2-pyridyl ketone and triethanolamine in MeCN, and they crystallize in the monoclinic space group C2/c. [Mn8Ln2] complexes have not been reported before, and the metallic cores of both complexes were unprecedented. In these cores, two Dy or Tb and two Mn ions comprised a well-known butterfly topology, with three of the remaining six Mn atoms each being situated on either side of the butterfly, linked through two μ3-O2- ions. Six MnIII and two MnII were in six-coordinated distorted octahedrons and two LnIII ions were in nine-coordinated distorted muffins. Interestingly, the coordination sites of LnIII ions are occupied by six O and two N atoms from two teaH2- ligands and one μ3-O2- atom, without the presence of coordinated solvent molecules such as H2O and small anions such as NO3- ions, which is rare in 3d-4f complexes. Remarkably, alternating current (ac) magnetic susceptibility measurements revealed that both complexes displayed dynamic anisotropic magnetic behaviour. The effective energy barrier (Ueff) of complex 2 was estimated to be 18.97 K through high frequency (111-9111 Hz) ac susceptibility measurements. The low symmetry of the coordination configuration of Ln3+ in 1 and 2 may be responsible for the small energy barriers of these two compounds.
- ArticleLouie JK, Jean C, Acosta M, Samuel MC, Matyas BT, Schechter R.PLoS One. 2011 Apr 05;6(4):e18221.BACKGROUND: While children and young adults had the highest attack rates due to 2009 pandemic (H1N1) influenza A (2009 H1N1), studies of hospitalized cases noted high fatality in older adults. We analyzed California public health surveillance data to better characterize the populations at risk for dying due to 2009 H1N1.
METHODS AND FINDINGS: A case was an adult ≥20 years who died with influenza-like symptoms and laboratory results indicative of 2009 H1N1. Demographic and clinical data were abstracted from medical records using a standardized case report form. From April 3, 2009-August 10, 2010, 541 fatal cases ≥20 years with 2009 H1N1 were reported. Influenza fatality rates per 100,000 population were highest in persons 50-59 years (3.5; annualized rate = 2.6) and 60-69 years (2.3; annualized rate = 1.7) compared to younger and older age groups (0.4-1.9; annualized rates = 0.3-1.4). Of 486 cases hospitalized prior to death, 441 (91%) required intensive care unit (ICU) admission. ICU admission rates per 100,000 population were highest in adults 50-59 years (8.6). ICU case-fatality ratios among adults ranged from 24-42%, with the highest ratios in persons 70-79 years. A total of 425 (80%) cases had co-morbid conditions associated with severe seasonal influenza. The prevalence of most co-morbid conditions increased with increasing age, but obesity, pregnancy and obstructive sleep apnea decreased with age. Rapid testing was positive in 97 (35%) of 276 tested. Of 482 cases with available data, 384 (80%) received antiviral treatment, including 49 (15%) of 328 within 48 hours of symptom onset.
CONCLUSIONS: Adults aged 50-59 years had the highest fatality due to 2009 H1N1; older adults may have been spared due to pre-existing immunity. However, once infected and hospitalized in intensive care, case-fatality ratios were high for all adults, especially in those over 60 years. Vaccination of adults older than 50 years should be encouraged. - ArticleMcGinnes LW, Morrison TG.Curr Protoc Microbiol. 2013 Oct 02;30:18.2.1-18.2.21.Virus-like particles (VLPs) are large particles, the size of viruses, composed of repeating structures that mimic those of infectious virus. Since their structures are similar to that of viruses, they have been used to study the mechanisms of virus assembly. They are also in development for delivery of molecules to cells and in studies of the immunogenicity of particle-associated antigens. However, they have been most widely used for development of vaccines and vaccine candidates. VLPs can form upon the expression of the structural proteins of many different viruses. This chapter describes the generation and purification of VLPs formed with the structural proteins, M, NP, F, and HN proteins, of Newcastle disease virus (NDV). Newcastle disease virus-like particles (ND VLPs) have also been developed as a platform for assembly into VLPs of glycoproteins from other viruses. This chapter describes the methods for this use of ND VLPs.
- ArticleShen C, Zhan W, Tang J, Wu Z, Xu B, Zhao C, Wang Z.ACS Appl Mater Interfaces. 2024 Apr 10;16(14):18213-18221.Substrate oxidation is inevitable when exposed to ambient atmosphere during semiconductor manufacturing, which is detrimental to the fabrication of state-of-the-art devices. Optimizing the deoxidation process in molecular beam epitaxy (MBE) for random substrates poses a multidimensional challenge and is sometimes controversial. Due to variations in substrates and growth processes, the determination of the deoxidation condition heavily relies on the individual's expertise, yielding inconsistent results. This study employs a machine learning model that integrates interpolation and vision transformer (Interpolation-ViT) techniques. The model utilizes reflection high-energy electron diffraction videos as input to predict the status of the substrate, enabling automated deoxidation within a controlled architecture for various substrates. Furthermore, we highlight the potential of models trained on data from specific MBE equipment to achieve high-accuracy deployment on different pieces of equipment. In contrast to traditional methods, our approach holds exceptional value, as it standardizes deoxidation temperatures across diverse equipment and substrates. This significantly advances the standardization of the semiconductor process. The concepts and methods presented are expected to revolutionize semiconductor manufacturing processes in the optoelectronic and microelectronic industries.
- ArticleCao Q, Dai YW, Xu J, Chen L, Zhu H, Sun QQ, Zhang DW.ACS Appl Mater Interfaces. 2017 May 31;9(21):18215-18221.Two-dimensional (2D) semiconductors have become promising candidates for nanoelectronics applications due to their unique layered structure and rich physical properties. However, the significant lack of reproducible p-type doping methods that can avoid the instability induced by the widely used charge transfer doping method greatly limits the applications of these semiconductors in complementary metal-oxide-semiconductor (CMOS) integrated digital circuits. This work presents a new scheme to realize stable p-type doping for WS2 with excellent layer controllability, wafer-level uniformity, and high reproducibility at the same time. The p-type WS2 was produced by introducing substitutional doping of sulfur with nitrogen atoms during the sulfurization of WOxNy film. Nitrogen atoms acted as acceptors moving the Fermi level of WS2 toward the valance band. Both experimental and theoretical investigations were designed to study the physical properties of the films fabricated. The WS2 based field-effect transistors exhibited a well-defined p-type behavior with a large on/off current ratio of ∼105 and a high hole mobility of ∼18.8 cm2 V-1 s-1. This opens up a promising method to realize stable p-type doping of 2D materials, which is very attractive for future large-scale 2D CMOS device applications.
- ArticleCarneiro ADS, Mesquita E, Meirelles LN, Bittencourt VREP, Golo PS.Rev Bras Parasitol Vet. 2022;31(1):e018221.The inappropriate use of synthetic acaricides has selected resistant Rhipicephalus microplus populations. The present study evaluated the compatibility of different Metarhizium spp. propagules (conidia, blastospores, and microsclerotia) by incubating them with synthetic acaricides (amitraz, deltamethrin, and a combination of cypermethrin, chlorpyrifos, and citronellal) for 1 h, 5 h, 10 h, and 24 h. Conidia and microsclerotia of the tested isolates were usually more tolerant to synthetic acaricides than blastospores. Our study also analyzed the in vitro effect of deltamethrin associated with fungal propagules for controlling a population of R. microplus females that were not susceptible to this synthetic acaricide. The use of entomopathogenic fungi in association with deltamethrin in this tick population caused a greater tick control than did the use of the fungus or the synthetic acaricide separately.
- ArticleDannemeyer M, Berling A, Kanje S, Enstedt H, Xu L, Afshari D, Westin M, Hober G, Uhlén M, Hober S, Tegel H.Protein Expr Purif. 2024 May 18;221:106505.Protein reagents are essential resources for several stages of drug discovery projects from structural biology and assay development through lead optimization. Depending on the aim of the project different amounts of pure protein are required. Small-scale expressions are initially used to determine the reachable levels of production and quality before scaling up protein reagent supply. Commonly, amounts of several hundreds of milligrams to grams are needed for different experiments, including structural investigations and activity evaluations, which require rather large cultivation volumes. This implies that cultivation of large volumes of either transiently transfected cells or stable pools/stable cell lines is needed. Hence, a production process that is scalable, speeds up the development projects, and increases the robustness of protein reagent quality throughout scales. Here we present a protein production pipeline with high scalability. We show that our protocols for protein production in Chinese hamster ovary cells allow for a seamless and efficient scale-up with robust product quality and high performance. The flexible scale of the production process, as shown here, allows for shorter lead times in drug discovery projects where there is a reagent demand for a specific protein or a set of target proteins.
- ArticleCheng E, Cole MW, Saam WF, Treiner J.Phys Rev B Condens Matter. 1993 Dec 15;48(24):18214-18221.
- ArticleLauber B, Gollhofer A, Taube W.J Exp Biol. 2018 10 18;221(Pt 20)The tibialis anterior (TA) and the soleus (SOL) are ankle joint muscles with functionally very different tasks. Thus, differences in motor cortical control between the TA and the SOL have been debated. This study compared the activity of the primary motor cortex during dynamic plantarflexions and dorsiflexions and compared this with measures obtained during rest. Single- and paired-pulse transcranial magnetic stimulations known as short-interval intracortical inhibition (SICI) were applied to the cortical representation of either the SOL or the TA muscle. The results show that the range of SICI from rest to activity is significantly greater in the TA than in the SOL. Furthermore, when the TA acts as the agonist during dorsiflexions of the ankle, SICI is almost absent (2.9%). When acting as the antagonist during plantarflexions, intracortical inhibition is significantly increased (28.7%). This task-specific modulation is far less pronounced in the SOL, which displayed higher levels of SICI when acting as the agonist (10.9%) during plantarflexion, but there was no significant inhibition (6.5%) as the antagonist during dorsiflexion. Furthermore, the cortical silent period (CSP) during plantarflexions was significantly longer in the SOL than in the TA during dorsiflexions, accompanied by a greater corticospinal excitability in the TA. Thus, cortical control considerably differs between the SOL and the TA in a way that inhibitory cortical control (SICI and CSP) of the TA is task-specifically adapted in a broader range of movements, whereas inhibition in the SOL muscle is less specific and more limited in its magnitude of modulation.