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  • Article
    Al-Shawba AA, Abdullah FA, Azmi A, Akbar MA, Nisar KS.
    Heliyon. 2023 May;9(5):e15717.
    In this study, the compatible extensions of the (G'/G)-expansion approach and the generalized (G'/G)-expansion scheme are proposed to generate scores of radical closed-form solutions of nonlinear fractional evolution equations. The originality and improvements of the extensions are confirmed by their application to the fractional space-time paired Burgers equations. The application of the proposed extensions highlights their effectiveness by providing dissimilar solutions for assorted physical forms in nonlinear science. In order to explain some of the wave solutions geometrically, we represent them as two- and three-dimensional graphs. The results demonstrate that the techniques presented in this study are effective and straightforward ways to address a variety of equations in mathematical physics with conformable derivative.
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  • Article
    You F, Li S.
    PeerJ. 2023;11:e15717.
    Environmental pollution and food safety have become key public health issues to be addressed in China. Since they are closely related to the green development of agriculture, it is of great practical significance to elucidate the intrinsic relationships between green development of agriculture, environmental regulation and residents' health. Based on the panel data of the Yangtze River Economic Belt from 2011 to 2020, this study investigates the impacts of environmental regulation and green development of agriculture on residents' health and the influencing mechanism by applying fixed effects method, mediating effectsmethod and the spatial Dubin method. Results show that the use of chemical fertilizers, pesticides and agricultural films is harmful to residents' health; environmental regulation has a negative correlation with the green development of agriculture and affect residents' health through mediating effects; the green development of agriculture has negative spillover effects on residents' health, indicating that purchasing finished products instead of producing locally reduces the input of production factors such as chemical fertilizers and pesticides and transfers health risks associated with agricultural production activities to neighboring areas. Intensifying command-and-control environmental regulation will induce the expansion of hidden economic activities and harm local residents' health, while intensifying market-incentive environmental regulation will lead to the 'Pollution Haven' phenomenon because of the 'race to the bottom', in government and is harmful to the health of residents in neighboring areas. Therefore, it is necessary to formulate reasonable and feasible policies and strengthen the control and prevention of agricultural pollution to enhance green development of agriculture and improve residents' health.
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  • Article
    Boccardo P, Chiabrando F, Dutto F, Tonolo FG, Lingua A.
    Sensors (Basel). 2015 Jul 02;15(7):15717-37.
    Exploiting the decrease of costs related to UAV technology, the humanitarian community started piloting the use of similar systems in humanitarian crises several years ago in different application fields, i.e., disaster mapping and information gathering, community capacity building, logistics and even transportation of goods. Part of the author's group, composed of researchers in the field of applied geomatics, has been piloting the use of UAVs since 2006, with a specific focus on disaster management application. In the framework of such activities, a UAV deployment exercise was jointly organized with the Regional Civil Protection authority, mainly aimed at assessing the operational procedures to deploy UAVs for mapping purposes and the usability of the acquired data in an emergency response context. In the paper the technical features of the UAV platforms will be described, comparing the main advantages/disadvantages of fixed-wing versus rotor platforms. The main phases of the adopted operational procedure will be discussed and assessed especially in terms of time required to carry out each step, highlighting potential bottlenecks and in view of the national regulation framework, which is rapidly evolving. Different methodologies for the processing of the acquired data will be described and discussed, evaluating the fitness for emergency response applications.
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  • Article
    Hu Z, Wang X, Yang Y, Zhao Y, Shen Z, Huang Y.
    Medicine (Baltimore). 2019 May;98(21):e15717.
    MicroRNAs (miRNAs) have been proved to be related to the development and progression of lung cancer. However, the expression signatures of miRNAs in lung adenocarcinoma in Xuanwei are not yet clear. The current study aimed to identify the potential miRNA profiles in lung adenocarcinoma in Xuanwei by microarray.The miRNA profiles in 24 lung adenocarcinoma and paired non-tumor tissues in Xuanwei were ascertained by using the Exiqon miRCURY LNA microRNA Array (v.18.0). The results of the microarrays were further verified by quantitative real-time polymerase chain reaction (qRT-PCR) detection. Bioinformatics analysis was used to carry out the functional annotations of differentially expressed miRNAs.One hundred fifty five differentially expressed (≥2-fold change) miRNAs were identified (65 upregulated and 90 downregulated). QRT-PCR was used to validate the top 4 most upregulated and downregulated miRNAs, and the results were generally consisted with microarray. Furthermore, the differentially expressed miRNAs were significantly enriched in numerous common pathways that were bound up with cancer. The pathways included focal adhesion and signaling pathways, such as cyclic guanosine monophosphate -protein kinase G (cGMP-PKG) signaling pathways, mitogen-activated protein kinase (MAPK) signaling pathway, and Hippo signaling pathway, etc.Our study identified the potential miRNA profiles in lung adenocarcinoma in Xuanwei by microarray. These miRNAs might be used as biomarkers for diagnosis and/or prognosis for lung cancer in Xuanwei and therefore warrant further investigation. Further study is needed to reveal the potential role of these miRNAs in the carcinogenesis of XuanWei Lung Cancer (XWLC).
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  • Article
    Wang J, Tang J, Ding B, Malgras V, Chang Z, Hao X, Wang Y, Dou H, Zhang X, Yamauchi Y.
    Nat Commun. 2017 06 12;8:15717.
    Although various two-dimensional (2D) nanomaterials have been explored as promising capacitive materials due to their unique layered structure, their natural restacking tendency impedes electrolyte transport and significantly restricts their practical applications. Herein, we synthesize all-carbon layer-by-layer motif architectures by introducing 2D ordered mesoporous carbons (OMC) within the interlayer space of 2D nanomaterials. As a proof of concept, MXenes are selected as 2D hosts to design 2D-2D heterostructures. Further removing the metal elements from MXenes leads to the formation of all-carbon 2D-2D heterostructures consisting of alternating layers of MXene-derived carbon (MDC) and OMC. The OMC layers intercalated with the MDC layers not only prevent restacking but also facilitate ion diffusion and electron transfer. The performance of the obtained hybrid carbons as supercapacitor electrodes demonstrates their potential for upcoming electronic devices. This method allows to overcome the restacking and blocking of 2D nanomaterials by constructing ion-accessible OMC within the 2D host material.
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  • Article
    Liu T, Li Y.
    Sci Rep. 2021 08 03;11(1):15717.
    Mega-urban agglomerations in developing countries have been main parts of economic development. But at the same time, they have become the most prominent and sensitive areas of resource and environment problems. It is important to clarify the mechanism and driving factors of green growth in mega-urban agglomerations. Based on the panel data of 28 major cities in China's Pan-Pearl River Delta urban agglomeration from 2006 to 2015, this paper evaluates the level of green development of urban agglomeration by green total factor productivity index (GTFP) based on Global Malmquist DEA model, and decomposes GTFP into technological progress, pure technical efficiency change, scale efficiency change and technological scale change. On this basis, this paper constructs a panel econometric model to analyze the influencing factors of GTFP and its decomposition factors. The results show that GTFP of Pan-Pearl River Delta urban agglomeration is growing, and the scale effect caused by technological progress is the main driving factor. Green development in the Pearl River Delta urban agglomeration takes into account efficiency and regional fairness, which causes differences in GTFP growth patterns of sub-urban agglomerations within mega-urban agglomerations. The technological progress and technical efficiency improvement are becoming the main driving force of GTFP growth in relatively backward areas. Furthermore, according to the influencing factors of GTFP and its decomposition factors, mega-urban agglomeration should eliminate internal administrative barriers to build an integrated market. It should also increase the proportion of technology industries in core cities, and give full play to the role of technology spillover effect on surrounding cities. In addition, improving the efficiency of resource and energy utilization is also helpful to promote the transformation of urban agglomeration development from factor-driven to efficiency-driven and innovation-driven. Our research results have implications for the coordinated development of economy and environment in developing countries.
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  • Article
    Naseh A, Ashrafzadeh S.
    Cureus. 2021 Jun;13(6):e15717.
    Although the Coronavirus Disease 2019 (COVID-19) has been found to have multiple routes of transmission, limited data exist on whether the vertical transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can occur from asymptomatic infected mothers to their newborns during pregnancy. We report a full-term newborn girl who was found to be positive for COVID-19 at 24 hours of life and subsequently symptomatic with fever, tachycardia, tachypnea, elevated lactate dehydrogenase, and elevated total bilirubin. The newborn was delivered by a mother who was not suspected of having COVID-19 before giving birth, but who developed fever and dyspnea five hours after delivery and was found to be positive for COVID-19. Upon further history collection, the mother reported recent mild nasal congestion in the days prior to delivery. This case highlights that the vertical transmission of COVID-19 to a newborn may occur late during the third trimester from a mother who was not suspected of having the infection. All pregnant women may need to be screened for COVID-19 symptoms, including non-specific symptoms, prior to admission for labor and delivery floors in order to perform diagnostic tests and recommended safety precautions to keep newborns and hospital personnel safe.
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  • Article
    Wang H, Han M, Li J, Hu Y, Chen Y, Li J.
    Nanoscale. 2023 Oct 05;15(38):15717-15729.
    The accumulation of amyloid-β (Aβ) into senile plaques and the resulting continuous oxidative stress are major pathogenic mechanisms in Alzheimer's disease (AD). In this study, we designed a lipoprotein-inspired nanoparticle to facilitate Aβ clearance and alleviate oxidative stress for the treatment of AD. Lipoprotein-like nanocomposites (RLA-rHDL@ANG) were fabricated by assembling reconstituted high density lipoprotein (rHDL) with an apoE-derived peptide (RLA) with Aβ binding and clearance capabilities, and were subsequently camouflaged using reactive oxygen species (ROS)-sensitive DSPE-TK-mPEG2000 and DSPE-TK-PEG3400-ANG with brain penetration as well as ROS scavenging ability. Immunoelectron microscopy, fluorescence colocalization, and enzyme linked immunosorbent assay, together with a thioflavin-T (ThT) fluorescence quantitative test, showed that RLA-rHDL@ANG possessed the ability of high binding affinity to both Aβ monomers and oligomers, and disintegration of pre-formed Aβ aggregates. ROS level monitoring and transmission electron microscopy (TEM) showed that RLA-rHDL@ANG possessed ROS sensitivity and consumption properties. Transcellular assay and in vivo imaging showed that RLA-rHDL@ANG effectively facilitated blood-brain barrier (BBB) penetration and intracerebral accumulation. It promoted the efficient degradation of Aβ by microglia and neurons through lysosomal transport and elimination approaches. Four-week administration of RLA-rHDL@ANG effectively reduced Aβ deposition, decreased the ROS level and improved cognitive functions in AD mice. These findings indicate that multifunctional RLA-rHDL@ANG may serve as a promising and feasible candidate for managing the progression of AD.
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  • Article
    Song B, Shi P, Xiao J, Song Y, Zeng M, Cao Y, Zhu X.
    Sci Rep. 2020 09 24;10(1):15717.
    An increasing number of studies have indicated that red blood cell distribution width (RDW) may be a novel biomarker for the diagnosis and prognosis of various malignancies. However, to date, data on the association of RDW with non-small cell lung cancer (NSCLC) are unclear. Our present study aimed to explore the value of RDW in NSCLC patients. A total of 338 NSCLC patients, 109 small cell lung cancer (SCLC) patients, and 302 healthy participants were retrospectively analyzed between January 2016 and December 2018. In the present study, we found that RDW was significantly increased in NSCLC patients. Receiver-operating characteristic (ROC) analysis showed that the area under the ROC curve (AUC) of RDW was 0.753 in discriminating NSCLC patients from healthy participants, the optimal cut-off value of RDW was 12.95, and the specificity and sensitivity were 76.33% and 76.16%, respectively. Further analysis found that RDW can enhance the diagnostic performance of Cyfra21-1 and NSE in discriminating NSCLC patients from healthy participants or SCLC patients. Among NSCLC patients, RDW was significantly correlated with TNM stage, T stage, N stage, M stage, and Cyfra21-1, indicating that RDW may be helpful for predicting the prognosis of NSCLC patients. Our findings suggest that RDW can be used as an auxiliary marker for the diagnosis and prognosis of NSCLC.
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  • Article
    Park HH, Han MH, Choi H, Lee YJ, Kim JM, Cheong JH, Ryu JI, Lee KY, Koh SH.
    Sci Rep. 2019 10 31;9(1):15717.
    Amlodipine, a L-type calcium channel blocker, has been reported to have a neuroprotective effect in brain ischemia. Mitochondrial calcium overload leads to apoptosis of cells in neurologic diseases. We evaluated the neuroprotective effects of amlodipine camsylate (AC) on neural stem cells (NSCs) injured by oxygen glucose deprivation (OGD) with a focus on mitochondrial structure and function. NSCs were isolated from rodent embryonic brains. Effects of AC on cell viability, proliferation, level of free radicals, and expression of intracellular signaling proteins were assessed in OGD-injured NSCs. We also investigated the effect of AC on mitochondrial structure in NSCs under OGD by transmission electron microscopy. AC increased the viability and proliferation of NSCs. This beneficial effect of AC was achieved by strong protection of mitochondria. AC markedly enhanced the expression of mitochondrial biogenesis-related proteins and mitochondrial anti-apoptosis proteins. Together, our results indicate that AC protects OGD-injured NSCs by protecting mitochondrial structure and function. The results of the present study provide insight into the mechanisms underlying the protective effects of AC on NSCs.
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  • Article
    Choi SY, Park JW, Koh YG, Jung YJ, Huh YJ, Ko EJ, Yoo KH, Seok J, Kim SY, Jue MS, Ko JY, Kim BJ.
    Dermatol Ther. 2022 09;35(9):e15717.
    Various treatment methods are used for noninvasive body contouring. To evaluate the efficacy and safety of a newly designed cryolipolysis device using a three-dimensional cooling method for abdominal fat reduction. Twenty-five participants with clinically apparent abdominal fat tissue participated in the study. The thickness of fat tissue below the umbilicus level was measured using a caliper at baseline and 12 weeks after the first treatment. The height of abdominal subcutaneous fat tissue on ultrasonography and participant satisfaction were assessed at every visit for 16 weeks. All adverse events (AEs) during the study period were recorded. p values <0.05 were considered statistically significant. Twenty-four participants completed this study; the mean BMI of participants was 29.34 ± 2.36 kg/m2 . The mean thickness of abdominal subcutaneous fat was significantly lower at 12 weeks (40.4 ± 6.8 mm, p < 0.001) than at baseline (49.3 ± 8.5 mm). Differences in the height of abdominal subcutaneous fat compared to that at baseline were 1.02 ± 0.41 cm (12 weeks, p < 0.001) and 1.13 ± 0.44 cm (16 weeks, p < 0.001). Rates of abdominal subcutaneous fat reduction at 12 and 16 weeks compared to that at baseline were 28.45% and 31.13%, respectively. The ratio of abdominal circumference to hip circumference at 12 and 16 weeks was significantly decreased compared to that at baseline. Most participants (95.8%) reported improvement in satisfaction scores at 16 weeks. There were no serious AEs during the entire study period. The study demonstrated the efficacy of a noninvasive cryolipolysis device using a three-dimensional cooling method for reducing abdominal subcutaneous fat.
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  • Article
    Cao Z, Shi D, Qu Y, Tao C, Liu W, Yao G.
    Molecules. 2013 Dec 16;18(12):15717-23.
    A new, simplified method for the synthesis of dimethyl aryl acylsulfonium salts has been developed. A series of dimethyl aryl acylsulfonium bromides were prepared by the reaction of aryl methyl ketones with hydrobromic acid and dimethylsulfoxide (DMSO). This sulfonium salt confirms that bromine production and the bromination reaction take place in the DMSO-HBr oxidation system. What's more, it is also a key intermediate for the synthesis of arylglyoxals.
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  • Article
    Wang J, Mo L, Ma Z.
    Sci Rep. 2023 Sep 21;13(1):15717.
    Based on the literature on the factors influencing port competitiveness, this paper evaluates the competitiveness of Chinese ports along the Belt and Road based on Porter's diamond model. The evaluation system includes four primary indicators, including port infrastructure, port operation scale, port hinterland economic level and port development potential, and 13 secondary indicators. Then, based on the entropy-TOPSIS method, an evaluation model of port competitiveness is constructed. Finally, 15 seaports along China's "Belt and Road" are used to evaluate competitiveness, and a comprehensive ranking of port competitiveness is obtained. The advantages and shortcomings of each port are pointed out according to the evaluation results to provide a reference for the long-term development of the competitiveness of ports along the "Belt and Road" in China.
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  • Article
    Lenoir D, Schramm KW.
    Nanoscale. 2017 Oct 19;9(40):15717-15718.
    Detoxification of cigarette smoke employing copper compounds has a potential for the formation of polychlorinated dibenzo-p-dioxins and dibenzofurans and should not be practiced before the degree of formation has been shown to be harmless.
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  • Article
    Kuwajima K, Ogawa M, Ruiz I, Yamane T, Hasegawa H, Yagi N, Rader F, Siegel RJ, Shiota T.
    Echocardiography. 2024 Jan;41(1):e15717.
    OBJECTIVES: Right ventricular (RV)-pulmonary arterial (PA) coupling is important in various cardiac diseases. Recently, several echocardiographic surrogates for RV-PA coupling have been proposed and reported to be useful in predicting outcomes. However, it remains unclear which surrogate is the most clinically relevant. This study aimed to comprehensively compare the prognostic value of different echocardiographic RV-PA coupling surrogates.
    METHODS: We retrospectively reviewed 242 patients with various cardiac conditions who underwent comprehensive transthoracic echocardiography with three-dimensional RV data. In addition to conventional parameters including tricuspid annular plane systolic excursion (TAPSE), fractional area change (FAC), and PA systolic pressure (PASP), we analyzed RV free wall and global longitudinal strain (FWLS and GLS). We also obtained RV ejection fraction (RVEF), stroke volume (SV), and end-systolic volume (ESV) using three-dimensional RV analysis. RV-PA coupling surrogates were calculated as TAPSE/PASP, FAC/PASP, FWLS/PASP, GLS/PASP, RVEF/PASP, and SV/ESV. The study endpoint was a composite outcome of all-cause death or cardiovascular hospitalization within 1 year.
    RESULTS: In multivariable analysis, all the RV-PA coupling surrogates were independent predictors of the outcome. Among the surrogates, the model with TAPSE/PASP showed the lowest prognostic value in model fit and discrimination ability, whereas the model with RVEF/PASP exhibited the highest prognostic value. The partial likelihood ratio test indicated that the model with RVEF/PASP was significantly better than the model with TAPSE/PASP (p < .024).
    CONCLUSION: All the RV-PA coupling surrogates were independent predictors of the outcome. Notably, RVEF/PASP had the highest prognostic value among the surrogates.
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  • Article
    Ourabah K.
    Sci Rep. 2022 Sep 20;12(1):15717.
    A singularity-free generalisation of Newtonian gravity can be constructed (Lazar in Phys Rev D 102:096002, 2020) within the framework of gradient field theory. This procedure offers a straightforward regularisation of Newtonian gravity and remains equally well applicable to other fields, such as electromagnetic fields. Here, with the aim of finding potentially measurable effects of gradient fields on the dispersion properties of various media, we present a quantum kinetic treatment of matter under gradient fields. The method is based on the application of the Wigner-Moyal procedure to the modified Schrödinger-Poisson equation emerging in the framework of gradient field theory. This allows us to treat, on equal footing, three different scenarios, namely self-gravitating systems, plasmas, and cold atoms in magneto-optical traps. We address the signature of gradient fields in the elementary excitations of these media. In particular, we estimate this effect to be accessible in state-of-the-art plasma-based experiments. We discuss in detail the classical kinetic and hydrodynamic limits of our approach and obtain a class of generalised Lane-Emden equations, in the context of gradient field theory, which remain valid in the three scenarios discussed here.
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  • Article
    Schroeder-Gloeckler JM, Rahman SM, Janssen RC, Qiao L, Shao J, Roper M, Fischer SJ, Lowe E, Orlicky DJ, McManaman JL, Palmer C, Gitomer WL, Huang W, O'Doherty RM, Becker TC, Klemm DJ, Jensen DR, Pulawa LK, Eckel RH, Friedman JE.
    J Biol Chem. 2007 May 25;282(21):15717-29.
    CCAAT/enhancer-binding protein beta (C/EBPbeta) plays a key role in initiation of adipogenesis in adipose tissue and gluconeogenesis in liver; however, the role of C/EBPbeta in hepatic lipogenesis remains undefined. Here we show that C/EBPbeta inactivation in Lepr(db/db) mice attenuates obesity, fatty liver, and diabetes. In addition to impaired adipogenesis, livers from C/EBPbeta(-/-) x Lepr(db/db) mice had dramatically decreased triglyceride content and reduced lipogenic enzyme activity. C/EBPbeta deletion in Lepr(db/db) mice down-regulated peroxisome proliferator-activated receptor gamma2 (PPARgamma2) and stearoyl-CoA desaturase-1 and up-regulated PPARalpha independent of SREBP1c. Conversely, C/EBPbeta overexpression in wild-type mice increased PPARgamma2 and stearoyl-CoA desaturase-1 mRNA and hepatic triglyceride content. In FAO cells, overexpression of the liver inhibiting form of C/EBPbeta or C/EBPbeta RNA interference attenuated palmitate-induced triglyceride accumulation and reduced PPARgamma2 and triglyceride levels in the liver in vivo. Leptin and the anti-diabetic drug metformin acutely down-regulated C/EBPbeta expression in hepatocytes, whereas fatty acids up-regulate C/EBPbeta expression. These data provide novel evidence linking C/EBPbeta expression to lipogenesis and energy balance with important implications for the treatment of obesity and fatty liver disease.
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  • Article
    Luft CD, Bhattacharya J.
    Sci Rep. 2015 Oct 27;5:15717.
    Recent studies showed that the visceral information is constantly processed by the brain, thereby potentially influencing cognition. One index of such process is the heartbeat evoked potential (HEP), an ERP component related to the cortical processing of the heartbeat. The HEP is sensitive to a number of factors such as motivation, attention, pain, which are associated with higher levels of arousal. However, the role of arousal and its associated brain oscillations on the HEP has not been characterized, yet it could underlie the previous findings. Here we analysed the effects of high- (HA) and low-arousal (LA) induction on the HEP. Further, we investigated the brain oscillations and their role in the HEP in response to HA and LA inductions. As compared to LA, HA was associated with a higher HEP and lower alpha oscillations. Interestingly, individual differences in the HEP modulation by arousal induction were correlated with alpha oscillations. In particular, participants with higher alpha power during the arousal inductions showed a larger HEP in response to HA compared to LA. In summary, we demonstrated that arousal induction affects the cortical processing of heartbeats; and that the alpha oscillations may modulate this effect.
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  • Article
    Górski G, Barański J, Weymann I, Domański T.
    Sci Rep. 2018 Oct 24;8(1):15717.
    We study the low energy spectrum and transport properties of a correlated quantum dot coupled between normal and superconducting reservoirs and additionally hybridized with a topological superconducting nanowire, hosting the Majorana end-modes. In this setup the Majorana quasiparticle leaking into the quantum dot can be confronted simultaneously with the on-dot pairing and correlations. We study this interplay, focusing on the quantum phase transition from the spinless (BCS-type) to the spinful (singly occupied) configuration, where the subgap Kondo effect may arise. Using the selfconsistent perturbative treatment for correlations and the unbiased numerical renormalization group calculations we find that the Majorana mode has either constructive or destructive effect on the low-energy transport behavior of the quantum dot, depending on its spin. This spin-selective influence could be verified by means of the polarized STM spectroscopy.
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  • Article
    Yan W, Mao L, Zhao P, Mertens A, Dottermusch S, Hu H, Jin Z, Richards BS.
    Opt Express. 2020 May 11;28(10):15706-15717.
    All-inorganic perovskites exhibit interesting properties and unprecedented stability compared to organic-inorganic hybrid lead halide perovskites. This work focuses on depositing and characterizing cesium lead bromide (CsPbBr3) thin films and determining their complex optical constants, which is a key requirement for photovoltaic device design. CsPbBr3 thin films are synthesized via the solution method followed by a hot-embossing step to reduce surface roughness. Variable angle spectroscopic ellipsometry measurements are then conducted at three angles (45°, 55°, and 65°) to obtain the ellipsometric parameters psi (Ψ) and delta (Δ). For the present model, bulk planar CsPbBr3 layer is described by a one-dimensional graded index model combined with the mixture of one Tauc-Lorentz oscillator and two Gaussian oscillators, while an effective medium approximation with 50% air void is adopted to describe surface roughness layer. The experimental complex optical constants are finally determined in the wavelength range of 300 to 1100 nm. Furthermore, as a design example demonstration, the simulations of single-junction CsPbBr3 solar cells are conducted via the finite-difference time-domain method to investigate the properties of light absorption and photocurrent density.
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