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- ArticleAndrés-Esteban EM, Quintana-Diaz M, Ramírez-Cervantes KL, Benayas-Peña I, Silva-Obregón A, Magallón-Botaya R, Santolalla-Arnedo I, Juárez-Vela R, Gea-Caballero V.PeerJ. 2021;9:e11260.BACKGROUND: The complications from coronavirus disease 2019 (COVID-19) have been the subject of study in diverse scientific reports. However, many aspects that influence the prognosis of the disease are still unknown, such as frailty, which inherently reduces resistance to disease and makes people more vulnerable. This study aimed to explore the complications of COVID-19 in patients admitted to a third-level hospital and to evaluate the relationship between these complications and frailty.
METHODS: An observational, descriptive, prospective study was performed in 2020. A sample of 254 patients from a database of 3,112 patients admitted to a high-level hospital in Madrid, Spain was analyzed. To assess frailty (independent variable) the Clinical Frailty Scale (CFS) was used. The outcome variables were sociodemographic and clinical, which included complications, length of stay, intensive care unit (ICU) admission and prognosis.
RESULTS: A total of 13.39% of the patients were pre-frail and 17.32% were frail. Frail individuals had a shorter hospital stay, less ICU admission, higher mortality and delirium, with statistical significance.
CONCLUSION: Frailty assessment is a crucial approach in patients with COVID-19, given a higher mortality rate has been demonstrated amongst frail patients. The CFS could be a predictor of mortality in COVID-19. - ArticleBates R, Battistin M, Berry S, Bitadze A, Bonneau P, Bousson N, Boyd G, Bozza G, Crespo-Lopez O, ... Show More Da Riva E, Degeorge C, Deterre C, DiGirolamo B, Doubek M, Favre G, Godlewski J, Hallewell G, Hasib A, Katunin S, Langevin N, Lombard D, Mathieu M, McMahon S, Nagai K, Pearson B, Robinson D, Rossi C, Rozanov A, Strauss M, Vitek M, Vacek V, Zwalinski L.Sensors (Basel). 2014 Jun 24;14(6):11260-76.We describe an ultrasonic instrument for continuous real-time analysis of the fractional mixture of a binary gas system. The instrument is particularly well suited to measurement of leaks of a high molecular weight gas into a system that is nominally composed of a single gas. Sensitivity < 5 × 10(-5) is demonstrated to leaks of octaflouropropane (C3F8) coolant into nitrogen during a long duration (18 month) continuous study. The sensitivity of the described measurement system is shown to depend on the difference in molecular masses of the two gases in the mixture. The impact of temperature and pressure variances on the accuracy of the measurement is analysed. Practical considerations for the implementation and deployment of long term, in situ ultrasonic leak detection systems are also described. Although development of the described systems was motivated by the requirements of an evaporative fluorocarbon cooling system, the instrument is applicable to the detection of leaks of many other gases and to processes requiring continuous knowledge of particular binary gas mixture fractions.
- ArticleReyes M, Monzón-Hernández D, Martínez-Ríos A, Silvestre E, Díez A, Cruz JL, Andrés MV.Sensors (Basel). 2013 Aug 23;13(9):11260-70.We report an easy-to-build, compact, and low-cost optical fiber refractive index sensor. It consists of a single fiber loop whose transmission spectra exhibit a series of notches produced by the resonant coupling between the fundamental mode and the cladding modes in a uniformly bent fiber. The wavelength of the notches, distributed in a wavelength span from 1,400 to 1,700 nm, can be tuned by adjusting the diameter of the fiber loop and are sensitive to refractive index changes of the external medium. Sensitivities of 170 and 800 nm per refractive index unit for water solutions and for the refractive index interval 1.40-1.442, respectively, are demonstrated. We estimate a long range resolution of 3 × 10(-4) and a short range resolution of 2 × 10(-5) for water solutions.
- ArticleChakraborty M, Chowdhury A, Bhusan R, DasGupta S.Langmuir. 2015 Oct 20;31(41):11260-8.Droplet motion on a surface with chemical energy induced wettability gradient has been simulated using molecular dynamics (MD) simulation to highlight the underlying physics of molecular movement near the solid-liquid interface including the contact line friction. The simulations mimic experiments in a comprehensive manner wherein microsized droplets are propelled by the surface wettability gradient against forces opposed to motion. The liquid-wall Lennard-Jones interaction parameter and the substrate temperature are varied to explore their effects on the three-phase contact line friction coefficient. The contact line friction is observed to be a strong function of temperature at atomistic scales, confirming their experimentally observed inverse functionality. Additionally, the MD simulation results are successfully compared with those from an analytical model for self-propelled droplet motion on gradient surfaces.
- ArticleLiyanage W, Vats K, Rajbhandary A, Benoit DS, Nilsson BL.Chem Commun (Camb). 2015 Jun 30;51(56):11260-3.Fmoc-3F-Phe-Arg-NH2 and Fmoc-3F-Phe-Asp-OH dipeptides undergo coassembly to form two-component nanofibril hydrogels. These hydrogels support the viability and growth of NIH 3T3 fibroblast cells. The supramolecular display of Arg and Asp at the nanofibril surface effectively mimics the integrin-binding RGD peptide of fibronectin, without covalent connection between the Arg and Asp functionality.
- ArticleIrzaman, Suryana Y, Pambudi S, Widayanti T, Jenie RP, Prastowo B, Har NP, Rahmawaty V, Dahrul M, Aminullah, Kurniawan A, Siskandar R, Hardyanto I, Iskandar J, Nurdin NM, Ardidarma A, Rahayu SK, Alatas H.Heliyon. 2022 Nov;8(11):e11260.Blood hemoglobin levels are a reliable indicator for anemia screening, which generally uses an invasive system or takes blood using a syringe. Spectrophotometry can work by "substituting" the use of a phlebotomy tube needle with electromagnetic wave radiation or light. This study aims to develop and carry out a noninvasive diagnostic test for measuring hemoglobin levels. There are three main stages in this research: (i) measuring hemoglobin concentration and scanning an incident wavelength on standard hemoglobin solutions and blood controls, (ii) making a prototype variant of a noninvasive blood hemoglobin level measurement device, and (iii) testing the technology unit on the developed prototype. The measured hemoglobin value by the Trax Control Meter for low, middle, and high levels is almost the same as the expected range values, namely, 13.09, 16.8, and 17.81 g/dL, respectively. Three sets of device prototype variants were successfully developed: (i) the noninvasive blood hemoglobin level measuring device based on Raspberry Pi Prototype on Infant Finger and Thigh Probes, (ii) the level measuring prototype noninvasive hemoglobin in blood based on Internet of Things and WebServer, and (iii) the prototype of noninvasive blood hemoglobin level measuring device on in vitro probe with reflectance method. Testing the accuracy of the Biorad MeterTrax Trilevel using a multiformula regression calculation using the ZunZun server shows that the tool has an accuracy ranging from 0.12 to 0.30 g/dL.
- ArticleJarva TM, Phillips NM, Von Eiff C, Poulakis GR, Naylor G, Feldheim KA, Flynt AS.Ecol Evol. 2024 May;14(5):e11260.Sawfishes (Pristidae) are large, highly threatened rays named for their tooth-studded rostrum, which is used for prey sensing and capture. Of all five species, the smalltooth sawfish, Pristis pectinata, has experienced the greatest decline in range, currently found in only ~20% of its historic range. To better understand the genetic underpinnings of these taxonomically and morphologically unique animals, we collected transcriptomic data from several tissue types, mapped them to the recently completed reference genome, and contrasted the patterns observed with comparable data from other elasmobranchs. Evidence of positive selection was detected in 79 genes in P. pectinata, several of which are involved in growth factor/receptor tyrosine kinase signaling and body symmetry and may be related to the unique morphology of sawfishes. Changes in these genes may impact cellular responses to environmental conditions such as temperature, dissolved oxygen, and salinity. Data acquired also allow for examination of the molecular components of P. pectinata electrosensory systems, which are highly developed in sawfishes and have likely been influential in their evolutionary success.
- ArticleBurrows AD, Jurcic M, Keenan LL, Lane RA, Mahon MF, Warren MR, Nowell H, Paradowski M, Spencer J.Chem Commun (Camb). 2013 Dec 14;49(96):11260-2.A series of new zinc-based metal-organic framework materials has been prepared in which deferiprone is incorporated as a chelating ligand on infinite or tri-zinc secondary building units following deprotonation. Deferiprone is immediately released from the MOFs on treatments with 1 N hydrochloric acid or buffer, but slow release is observed in ethanoic acid.
- ArticleWalsh CJ, Batt J, Herridge MS, Mathur S, Bader GD, Hu P, Khatri P, Dos Santos CC.Sci Rep. 2022 07 04;12(1):11260.Muscle diseases share common pathological features suggesting common underlying mechanisms. We hypothesized there is a common set of genes dysregulated across muscle diseases compared to healthy muscle and that these genes correlate with severity of muscle disease. We performed meta-analysis of transcriptional profiles of muscle biopsies from human muscle diseases and healthy controls. Studies obtained from public microarray repositories fulfilling quality criteria were divided into six categories: (i) immobility, (ii) inflammatory myopathies, (iii) intensive care unit (ICU) acquired weakness (ICUAW), (iv) congenital muscle diseases, (v) chronic systemic diseases, (vi) motor neuron disease. Patient cohorts were separated in discovery and validation cohorts retaining roughly equal proportions of samples for the disease categories. To remove bias towards a specific muscle disease category we repeated the meta-analysis five times by removing data sets corresponding to one muscle disease class at a time in a "leave-one-disease-out" analysis. We used 636 muscle tissue samples from 30 independent cohorts to identify a 52 gene signature (36 up-regulated and 16 down-regulated genes). We validated the discriminatory power of this signature in 657 muscle biopsies from 12 additional patient cohorts encompassing five categories of muscle diseases with an area under the receiver operating characteristic curve of 0.91, 83% sensitivity, and 85.3% specificity. The expression score of the gene signature inversely correlated with quadriceps muscle mass (r = -0.50, p-value = 0.011) in ICUAW and shoulder abduction strength (r = -0.77, p-value = 0.014) in amyotrophic lateral sclerosis (ALS). The signature also positively correlated with histologic assessment of muscle atrophy in ALS (r = 0.88, p-value = 1.62 × 10-3) and fibrosis in muscular dystrophy (Jonckheere trend test p-value = 4.45 × 10-9). Our results identify a conserved transcriptional signature associated with clinical and histologic muscle disease severity. Several genes in this conserved signature have not been previously associated with muscle disease severity.
- ArticleIqbal MZ, Chung TW, Nam MJ, Yoshimoto K.Sci Rep. 2021 May 27;11(1):11260.Separated attenuation values have not been used in post-seismic variation research, although the scattering attenuation (Qs-1) parameter that can be used to estimate crustal inhomogeneity due to cracks. In this study, three earthquakes that occurred in Kumamoto (M7.3), Tottori (M6.6), and Gyeongju (M5.8) in 2016 were investigated by applying a multiple lapse time window analysis to seismograms recorded before and after the events. At a low frequency, significantly greater variation of the Qs-1 value was observed than the intrinsic attenuation (Qi-1) for the Kumamoto earthquake, whereas similarly large variation was observed for the Gyeongju earthquake. For the surrounding Kumamoto earthquake area of increased attenuation, even higher decreases in Qs-1 and Qi-1 were also observed. The increases occurred within a two year-period after mainshock. The large increases in attenuation, corresponding to regions with high peak ground acceleration, were limited to the basin area with an elevation below 500 m. Furthermore, post-seismic increases in attenuation values were found to correlate with the magnitude and length of the quiet periods of the earthquakes. From this study, Qs-1 and Qi-1 were shown as new parameters that can quantitatively measure the post-seismic deformation due to crustal earthquake.
- ArticleHerzog G, Benecke G, Buffet A, Heidmann B, Perlich J, Risch JF, Santoro G, Schwartzkopf M, Yu S, Wurth W, Roth SV.Langmuir. 2013 Sep 10;29(36):11260-6.We investigated the spray deposition and subsequent self-assembly during drying of a polystyrene nanoparticle dispersion with in situ grazing incidence small-angle X-ray scattering at high time resolution. During the fast deposition of the dispersion and the subsequent evaporation of the solvent, different transient stages of nanoparticle assembly can be identified. In the first stage, the solvent starts to evaporate without ordering of the nanoparticles. During the second stage, large-scale structures imposed by the breakup of the liquid film are observable. In this stage, the solvent evaporates further and nanoparticle ordering starts. In the late third drying stage, the nanoparticles self-assemble into the final layer structure.
- ArticleAlbaqami M, Hammad M, Pooam M, Procopio M, Sameti M, Ritz T, Ahmad M, Martino CF.Sci Rep. 2020 07 09;10(1):11260.How living systems respond to weak electromagnetic fields represents one of the major unsolved challenges in sensory biology. Recent evidence has implicated cryptochrome, an evolutionarily conserved flavoprotein receptor, in magnetic field responses of organisms ranging from plants to migratory birds. However, whether cryptochromes fulfill the criteria to function as biological magnetosensors remains to be established. Currently, theoretical predictions on the underlying mechanism of chemical magnetoreception have been supported by experimental observations that exposure to radiofrequency (RF) in the MHz range disrupt bird orientation and mammalian cellular respiration. Here we show that, in keeping with certain quantum physical hypotheses, a weak 7 MHz radiofrequency magnetic field significantly reduces the biological responsivity to blue light of the cryptochrome receptor cry1 in Arabidopsis seedlings. Using an in vivo phosphorylation assay that specifically detects activated cryptochrome, we demonstrate that RF exposure reduces conformational changes associated with biological activity. RF exposure furthermore alters cryptochrome-dependent plant growth responses and gene expression to a degree consistent with theoretical predictions. To our knowledge this represents the first demonstration of a biological receptor responding to RF exposure, providing important new implications for magnetosensing as well as possible future applications in biotechnology and medicine.
- ArticleHotchen CE, Maybury IJ, Nelson GW, Foord JS, Holdway P, Marken F.Phys Chem Chem Phys. 2015 May 07;17(17):11260-8."Amplified" electron transfer is observed purely based on electron transfer kinetic effects at modified carbon surfaces. An anodic attachment methodology is employed to modify the surface of glassy carbon or boron doped diamond electrodes with poly-ethylene glycols (PEGs) for polymerisation degrees of n = 4.5 to 9.1 (PEG200 to PEG400). Voltammetry and impedance data for aqueous Fe(CN)6(3-/4-) suggest systematic PEG structure-dependent effects on the standard rate constant for heterogeneous electron transfer as a function of PEG deposition conditions and average polymer chain length. Tunnel distance coefficients are polymerisation degree dependent and estimated for shorter PEG chains, β = 0.17 Å(-1) for aqueous Fe(CN)6(3-/4-), consistent with a diffuse water-PEG interface. In contrast, electron transfer to 1,1'-ferrocene-dimethanol (at 1 mM concentration) appears un-impeded by PEG grafts. Mediated or "amplified" electron transfer to Fe(CN)6(3-/4-) based on the 1,1'-ferrocene-dimethanol redox shuttle is observed for both oxidation and reduction with estimated bimolecular rate constants for homogeneous electron transfer of kforward = 4 × 10(5) mol dm(3) s(-1) and kbackward = 1 × 10(5) mol dm(3) s(-1). Digital simulation analysis suggests an additional resistive component within the PEG graft double layer.
- ArticleAmann S, Witzleben MV, Breuer S.Sci Rep. 2019 08 02;9(1):11260.Digital holographic microscopy is an emerging, potentially low-cost alternative to conventional light microscopy for micro-object imaging on earth, underwater and in space. Immediate access to micron-scale objects however requires a well-balanced system design and sophisticated reconstruction algorithms, that are commercially available, however not accessible cost-efficiently. Here, we present an open-source implementation of a lens-less digital inline holographic microscope platform, based on off-the-shelf optical, electronic and mechanical components, costing less than $190. It employs a Blu-Ray semiconductor-laser-pickup or a light-emitting-diode, a pinhole, a 3D-printed housing consisting of 3 parts and a single-board portable computer and camera with an open-source implementation of the Fresnel-Kirchhoff routine. We demonstrate 1.55 μm spatial resolution by laser-pickup and 3.91 μm by the light-emitting-diode source. The housing and mechanical components are 3D printed. Both printer and reconstruction software source codes are open. The light-weight microscope allows to image label-free micro-spheres of 6.5 μm diameter, human red-blood-cells of about 8 μm diameter as well as fast-growing plant Nicotiana-tabacum-BY-2 suspension cells with 50 μm sizes. The imaging capability is validated by imaging-contrast quantification involving a standardized test target. The presented 3D-printable portable open-source platform represents a fully-open design, low-cost modular and versatile imaging-solution for use in high- and low-resource areas of the world.
- ArticleZhai T, Yan J, Shi X, Ruan J, Tong J, Liang N.Nanoscale. 2022 Aug 11;14(31):11252-11260.Chaotic cryptography as an important means for digital image encryption has become a great cryptographic project in the current information age. As a novel microcavity laser, a random laser (RL) has a natural advantage for a chaotic system, relying on its spectral randomness. Nevertheless, this encrypted image generally suffers from outline exposition when an unsuitable key from a single RL spectrum is employed. Herein, to realize reliable dual chaotic encryption, an internally integrated hybrid microcavity in random and whispering-gallery-mode (WGM) is reported. Within this coupled microcavity, the rhodamine-6G-doped inner-wall of the fiber serves as the gain medium and the optical cavities for WGM lasing; an RL mode is enabled by scattered particles and the gain medium (Rh6G). Interestingly, the smooth inner wall of the fiber with a high-quality (Q) factor and tight optical confinement make WGM lasing occur earlier than RL. What is more, a fast energy transfer process from the WGM laser to Ag nanoparticles and the resultant localized surface plasmon resonance effects from Ag NPs to RL jointly promote the output of the random laser. As a result, a free transformation from the WGM laser to RL is successfully modulated by varying the pump power alone, thus providing two initial values for dual chaos image encryption. This work provides an in-depth understanding of a WGM-random inner-coupled cavity and promotes the application of a hybrid microcavity in the field of information security.
- ArticleSamantray SR, Mohapatra I.Cureus. 2020 Oct 30;12(10):e11260.Small bowel prolapse through uterine perforation is a rare but severe complication of unsafe abortion. Early recognition of the bowel prolapse, aggressive resuscitation and prompt surgical intervention can reduce the morbidity and mortality related to these kinds of injuries. We present here a case of small intestine prolapse through uterine perforation following dilatation and curettage requiring intestinal resection. Efforts have to be made to reduce the number of unsafe abortions.
- ArticleWeigt D, Sammour DA, Ulrich T, Munteanu B, Hopf C.Sci Rep. 2018 07 26;8(1):11260.Recent advances in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry have enabled whole cell-MALDI mass spectrometry biotyping of drug-treated cultured cells for rapid monitoring of known abundant pharmacodynamic protein markers such as polyacetylated histones. In contrast, generic and automated analytical workflows for discovery of such pharmacodynamic markers, in particular lipid markers, and their use in cellular tests of drug-like compounds are still lacking. Here, we introduce such a workflow and demonstrate its utility for cellular drug-response monitoring of BCR-ABL tyrosine kinase inhibitors in K562 leukemia cells: First, low-molecular mass features indicating drug responses are computationally extracted from groups of MALDI-TOF mass spectra. Then, the lipids/metabolites corresponding to these features are identified by MALDI-Fourier transformation mass spectrometry. To demonstrate utility of the method, we identify the potassium adduct of phosphatidylcholine PC(36:1) as well as heme B, a marker for erythroid differentiation, as markers for a label-free MALDI MS-based test of cellular responses to BCR-ABL inhibitors. Taken together, these results suggest that MALDI-TOF mass spectrometry of lipids and other low molecular mass metabolites could support cell-based drug profiling.
- ArticleDi Meo I, Colombelli C, Srinivasan B, de Villiers M, Hamada J, Jeong SY, Fox R, Woltjer RL, Tepper PG, Lahaye LL, Rizzetto E, Harrs CH, de Boer T, van der Zwaag M, Jenko B, Čusak A, Pahor J, Kosec G, Grzeschik NA, Hayflick SJ, Tiranti V, Sibon OCM.Sci Rep. 2017 09 12;7(1):11260.Coenzyme A is an essential metabolite known for its central role in over one hundred cellular metabolic reactions. In cells, Coenzyme A is synthesized de novo in five enzymatic steps with vitamin B5 as the starting metabolite, phosphorylated by pantothenate kinase. Mutations in the pantothenate kinase 2 gene cause a severe form of neurodegeneration for which no treatment is available. One therapeutic strategy is to generate Coenzyme A precursors downstream of the defective step in the pathway. Here we describe the synthesis, characteristics and in vivo rescue potential of the acetyl-Coenzyme A precursor S-acetyl-4'-phosphopantetheine as a possible treatment for neurodegeneration associated with pantothenate kinase deficiency.
- ArticleHu Y, Lyu L, Wang N, Zhou X, Fang M.Sci Rep. 2023 Jul 12;13(1):11260.Time series prediction of river water quality is an important method to grasp the changes of river water quality and protect the river water environment. However, due to the time series data of river water quality have strong periodicity, seasonality and nonlinearity, which seriously affects the accuracy of river water quality prediction. In this paper, a new hybrid deep neural network model is proposed for river water quality prediction, which is integrated with Savitaky-Golay (SG) filter, STL time series decomposition method, Self-attention mechanism, and Temporal Convolutional Network (TCN). The SG filter can effectively remove the noise in the time series data of river water quality, and the STL technology can decompose the time series data into trend, seasonal and residual series. The decomposed trend series and residual series are input into the model combining the Self-attention mechanism and TCN respectively for training and prediction. In order to verify the proposed model, this study uses opensource water quality data and private water quality data to conduct experiments, and compares with other water quality prediction models. The experimental results show that our method achieves the best prediction results in the water quality data of two different rivers.
- ArticleBöhmer J, Wasslavik C, Andersson D, Ståhlberg A, Jonsson M, Wåhlander H, Karason K, Sunnegårdh J, Nilsson S, Asp J, Dellgren G, Ricksten A.Transpl Int. 2023;36:11260.In this prospective study we investigated a cohort after heart transplantation with a novel PCR-based approach with focus on treated rejection. Blood samples were collected coincidentally to biopsies, and both absolute levels of dd-cfDNA and donor fraction were reported using digital PCR. 52 patients (11 children and 41 adults) were enrolled (NCT03477383, clinicaltrials.gov), and 557 plasma samples were analyzed. 13 treated rejection episodes >14 days after transplantation were observed in 7 patients. Donor fraction showed a median of 0.08% in the cohort and was significantly elevated during rejection (median 0.19%, p < 0.0001), using a cut-off of 0.1%, the sensitivity/specificity were 92%/56% (AUC ROC-curve: 0.78). Absolute levels of dd-cfDNA showed a median of 8.8 copies/mL and were significantly elevated during rejection (median 23, p = 0.0001). Using a cut-off of 7.5 copies/mL, the sensitivity/specificity were 92%/43% for donor fraction (AUC ROC-curve: 0.75). The results support the feasibility of this approach in analyzing dd-cfDNA after heart transplantation. The obtained values are well aligned with results from other trials. The possibility to quantify absolute levels adds important value to the differentiation between ongoing graft damage and quiescent situations.